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Year : 1999  |  Volume : 47  |  Issue : 2  |  Page : 104--7

Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.


Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India., India

Correspondence Address:
S K Garg
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.
India
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PMID: 10402333

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The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentration and elimination half life were significantly increased and t-max was significantly reduced, indicating the suppression of phenytoin metabolism by 'Mentat'.






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