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 ORIGINAL ARTICLE
Year : 2003  |  Volume : 51  |  Issue : 1  |  Page : 60--62

Free radical toxicity and antioxidants in Parkinsonís disease


1 Departments of Biochemistry, Kasturba Medical College, Mangalore, India
2 Department of Biochemistry, Father Mullers Medical College, Mangalore, India
3 Departments of Neurology, Kasturba Medical College, Mangalore, India
4 Department of Biochemistry, Kasturba Medical College, Manipal-576119, India

Correspondence Address:
A Rao
Kasturba Medical College, Manipal-576119
India
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Source of Support: None, Conflict of Interest: None


PMID: 12865518

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Erythrocyte lipid peroxidation, oxidative hemolysis, erythrocyte antioxidant enzymes, viz. superoxide dismutase, glutathione reductase, glutathione peroxidase, catalase and plasma antioxidants, viz. vitamin A, vitamin E, vitamin C and ceruloplasmin have been determined by spectrophotometric methods in 15 patients with Parkinsonís disease (PD) and in 50 controls. Lipid peroxidation, oxidative hemolysis and plasma ceruloplasmin were significantly higher in PD patients as compared to normals. Erythrocyte antioxidants in PD patients were not significantly different from the controls. However, plasma vitamin C in PD patients was significantly lower than the controls. It is concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in PD.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow