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LETTER TO EDITOR
Year : 2004  |  Volume : 52  |  Issue : 2  |  Page : 271

Satoyoshi syndrome: Comments


Mayo Clinic , Rochester, MN, USA

Correspondence Address:
Mayo Clinic , Rochester, MN, USA



How to cite this article:
Varkey BM. Satoyoshi syndrome: Comments. Neurol India 2004;52:271


How to cite this URL:
Varkey BM. Satoyoshi syndrome: Comments. Neurol India [serial online] 2004 [cited 2019 Nov 17];52:271. Available from: http://www.neurologyindia.com/text.asp?2004/52/2/271/11068


Sir,
I read with interest a case report of Satoyoshi syndrome by Ashalatha et al.[1] The similarity with a 'jerking stiff-man syndrome' -a variant of stiff-man syndrome (SMS) is striking. Distal limb involvement, myoclonic jerking, board-like muscles, stimulus-evoked spasms, endocrinopathies, vitiligo, pernicious anemia and sicca syndrome can also be seen in jerking SMS.[2] Continuous motor unit activity (CMUA) is necessary to diagnose this variant but can sometimes be elusive and manifest only in the paraspinal muscles.[3] Earlier this year, anti-GAD antibodies were described with Satoyoshi syndrome.[4] This validates the auto-immune nature of this disorder and suggests that it might be a variant of stiff-man syndrome. In both cases, a partial response to immunomodulating agents such as immuno-globulin or high dose steroids may be seen. I wonder if anti-GAD antibodies could be tested in the described case as well.
 

  References Top

1.Ashalatha R, Kishore A, Sarada C, Nair MD. Satayoshi syndrome. Neurol India 2004;52:94-5.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Meinck HM, Thompson PD. Stiff man syndrome and related conditions. Mov Disord. 2002;17:853-66.  Back to cited text no. 2  [PUBMED]  [FULLTEXT]
3.Brown P, Marsden CD. The stiff man and stiff man plus syndromes.J Neurol. 1999;246:648-52.   Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Drost G, Verrips A, Hooijkaas H, Zwarts M. Glutamic acid decarboxylase antibodies in Satoyoshi syndrome. Ann Neurol. 2004;55:450-1.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]

 

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Online since 20th March '04
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