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Year : 2005  |  Volume : 53  |  Issue : 2  |  Page : 255

Multiple intracranial meningiomas do not imply neurofibromatosis

Department of Neurosurgery, Neurosciences center, All India Institute of Medical Sciences, New Delhi, India

Correspondence Address:
Ashok Kumar Mahapatra
Department of Neurosurgery, Neurosciences center, AIIMS, New Delhi - 110 029
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.16441

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How to cite this article:
Agrawal D, Mahapatra AK. Multiple intracranial meningiomas do not imply neurofibromatosis. Neurol India 2005;53:255

How to cite this URL:
Agrawal D, Mahapatra AK. Multiple intracranial meningiomas do not imply neurofibromatosis. Neurol India [serial online] 2005 [cited 2019 Dec 15];53:255. Available from:

A 27-year-old female presented with a 6-month history of occasional mild to moderate headache. There was no history of NF2 or meningiomatosis in the family and the patient was neurologically intact. There were no features of neurofibromatosis such as cafe-au-lait spots, subcutaneous neurofibromas, axillary freckling, Lisch nodules, or bony dysplasias. Contrast magnetic resonance imaging (MRI) of the brain revealed more than 20 meningiomas in various locations [Figure - 1], [Figure - 2], [Figure - 3]. Both the CP angles also contained meningiomas. The Patient underwent removal of the anteriorly located olfactory groove, falcine, and parasagittal meningiomas and is presently on follow up.

Though there are various criteria for the diagnosis of NF2,[1] all require either a family history of NF2 or presence of a vestibular schwannoma. Our patient did not have either. Families with multiple meningiomas have been reported, without chromosome 22q deletions, and it is hypothesized that this disorder may result from alterations in other negative growth regulators important for meningeal cell growth and differentiation.[2] It is likely that our case too belonged to this category.

  References Top

1.Baser ME, Friedman JM, Wallace AJ, Ramsden RT, Joe H, Evans DJR. Evaluation of clinical diagnostic criteria for neurofibromatosis 2. Neurology 2002;59:1759-65.  Back to cited text no. 1    
2.Pulst SM, Rouleau GA, Marineau C, Fain P, Sieb JP. Familial meningioma is not allelic to neurofibromatosis 2. Neurology 1993;43:2096-8.  Back to cited text no. 2    


[Figure - 1], [Figure - 2], [Figure - 3]


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