Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 2710  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  ╗ Next article
  ╗ Previous article 
  ╗ Table of Contents
  
 Resource Links
  ╗  Similar in PUBMED
 ╗  Search Pubmed for
 ╗  Search in Google Scholar for
  ╗  Article in PDF (136 KB)
  ╗  Citation Manager
  ╗  Access Statistics
  ╗  Reader Comments
  ╗  Email Alert *
  ╗  Add to My List *
* Registration required (free)  

 
  In this Article
   References
   Article Figures

 Article Access Statistics
    Viewed3943    
    Printed108    
    Emailed1    
    PDF Downloaded129    
    Comments [Add]    
    Cited by others 8    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 2006  |  Volume : 54  |  Issue : 2  |  Page : 213-214

Abscess formation in Rathke's cleft cyst


Dr. Lutfi Kirdar Kartal Research and Training Hospital,2nd Neurosurgery Clinic, Istanbul, Turkey

Correspondence Address:
Burak O Boran
Dr. Lutfi Kirdar Kartal Research and Training Hospital,2nd Neurosurgery Clinic, Istanbul
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


PMID: 16804275

Rights and PermissionsRights and Permissions



How to cite this article:
Celikoglu E, Boran BO, Bozbuga M. Abscess formation in Rathke's cleft cyst. Neurol India 2006;54:213-4

How to cite this URL:
Celikoglu E, Boran BO, Bozbuga M. Abscess formation in Rathke's cleft cyst. Neurol India [serial online] 2006 [cited 2020 Apr 3];54:213-4. Available from: http://www.neurologyindia.com/text.asp?2006/54/2/213/25959


Sir,

Abscess formation within a Rathke's cleft cyst (RCC) is extremely rare and only 11 cases are reported in the literature.[1],[2],[3],[4] In this letter, we report two cases of Rathke's cleft cyst abscess.

A 48-year-old woman was presented with a 3 year history of deteriorating vision. Prolactin was found to be mildly elevated (37.6 ng/ml) in laboratory investigations. Magnetic resonance imaging (MRI) demonstrated a cystic sellar lesion with suprasellar extension [Figure - 1]. The lesion has demonstrated rim enhancement following contrast administration. The lesion was approached transsphenoidally. The abscess was drained and biopsy was taken from the cyst wall. Pus culture was negative. Pathological examination of the cyst wall revealed cuboidal epithelium, intervened between non-neoplastic anterior pituitary tissue. Patient received vancomycin, ceftriaxone and metronidazole for 6 weeks.

A 37-year-old woman was presented with a 2 year history of galactorrhea and amennorhea and 3 month history of deteriorating vision. Prolactin was found to be moderately elevated (83.4 ng/ml). MRI revealed a cystic sellar - suprasellar lesion, which was hyperintense on T2-weighted images and isointense on T1-weighted images, demonstrating rim enhancement following contrast administration [Figure - 2]. The lesion was approached transsphenoidally. Pus culture grew no organisms. Pathological examination revealed cuboidal epithelium, intervened between normal anterior pituitary tissue [Figure - 3]. There was also a region of squamous metaplasia. Triple antibiotic therapy was initiated following surgery. Follow-up MRI images performed 9 months after the surgery demonstrated reaccumulation of the abscess. The patient underwent a second session of transsphenoidal drainage followed by 6 weeks of antibiotic therapy.

Primary pituitary abscesses generally occur within normal pituitary gland and abscesses that occur within a sellar pathology, such as adenoma, craniopharyngioma, or RCC, are called secondary pituitary abscess.[6] When the reported cases are reviewed, a possible predisposing factor can be mentioned in only two cases: A patient with sphenoid sinusitis and an immunosuppressed patient receiving methotrexate for the treatment of psoriasis.[1],[2],[3],[4] Only 4 of the patients in the literature were admitted with the findings of an infection. Remaining cases have presented with visual and endocrine disturbance. On MRI, the lesion was sellar and having a suprasellar component in majority, generally homogeneous, hyperintense on T2-weighted images and isointense on T1 weighted images, with a typical rim enhancement following contrast administration.[1],[2],[3],[4]

These lesions should be approached transsphenoidally, in order to prevent the spread of the infection into the intracranial compartment.[6] The material within the cyst is purulent. Histological examination reveals polymorphonuclear leukocytes within eosinophilic material. Gram stain is generally negative and Gram (-) rods were identified in only one case in the literature. Culture of the abscess content was positive only in four of the reported cases and the isolated organisms were: Acinetobacter Iwoffi, Staphylococcus epidermidis, Staphylococcus aureus Scientific Name Search  and Streptococcus pyogenes.[1],[2],[3],[4]

RCC are generally composed of a fibrous wall with a single layer of cuboidal or columnar and frequently ciliated epithelium.[5] But in cases of abscess formation, it has been proposed that, lining epithelium undergoes metaplasia and simple or stratified squamous epithelium is encountered. The absence of keratohyaline granules in the epithelium and of keratin debris in the content of the abscess excludes a diagnosis of epidermoid cyst.[1],[2],[3],[4]

Following drainage of the abscess, parenteral antibiotic treatment should be initiated. Empiric therapy consists of vancomycin, ceftriaxone and metronidazole for at least 4 weeks.[6] The abscess had recurred in six of the reported cases.



 
  References Top

1.Sonntag VK, Plenge KL, Balis MS, Raudzens PA, Hodak JA, Clark RJ, et al . Surgical treatment of an abscess in a Rathke's cleft cyst. Surg Neurol 1983;20:152-6.  Back to cited text no. 1    
2.Bognar L, Szeifert GT, Fedorcsak I, Pasztor E. Abscess formation in Rathke's cleft cyst. Acta Neurochir Wien 1992;117:70-2.  Back to cited text no. 2    
3.Thomas N, Wittert GA, Scott G, Reilly PL. Infection of a Rathke's cleft cyst: a rare cause of pituitary abscess. Case illustration. J Neurosurg 1998;89:682.  Back to cited text no. 3    
4.Israel ZH, Yacoub M, Gomori JM, Dotan S, Fellig Y, Shoshan Y, et al . Rathke's cleft cyst abscess. Pediatr Neurosurg 2000;33:159-61.  Back to cited text no. 4    
5.Voelker JL, Campbell RL, Muller J. Clinical, radiographic and pathological features of symptomatic Rathke's cleft cyst. J Neurosurg 1991;74:535-44.  Back to cited text no. 5    
6.Vates GE, Berger MS, Wilson CB. Diagnosis and management of pituitary abscess: a review of twenty-four cases. J Neurosurg 2001;95:233-41.  Back to cited text no. 6    


    Figures

[Figure - 1], [Figure - 2], [Figure - 3]

This article has been cited by
1 A pituitary abscess masquerading as recurrent hypernatremia and aseptic meningitis
Gonzales, M. and Marik, P.E. and Khardori, R.K. and OŠBrian, J.T.
BMJ Case Reports. 2012;
[Pubmed]
2 Pituitary abscess manifesting as meningitis and photophobia associated with rathkeŠs cleft cyst in a child: Case report
Uchiyama, T. and Sakai, K. and Asanuma, M. and Aoyama, T. and Hongo, K.
Neurologia Medico-Chirurgica. 2011; 51(6): 455-459
[Pubmed]
3 Diagnosis and management of pituitary abscess: Experiences from 33 cases
Liu, F., Li, G., Yao, Y., Yang, Y., Ma, W., Li, Y., Chen, G., Wang, R.
Clinical Endocrinology. 2011; 74(1): 79-88
[Pubmed]
4 Clinical, imaging and pathological features of infected atypical rathkeŠs cleft cyst with secondary pituitary abscess formation
Azad, R., Azad, S., Ahmad, A., Arora, P.
Journal of Clinical and Diagnostic Research. 2010; 4(5): 3237-3240
[Pubmed]
5 Clinicopathological characteristics in patients presenting with acute onset of symptoms caused by RathkeŠs cleft cysts
Komatsu, F., Tsugu, H., Komatsu, M., Sakamoto, S., Oshiro, S., Fukushima, T., Nabeshima, K., Inoue, T.
Acta Neurochirurgica. 2010; 152(10): 1673-1678
[Pubmed]
6 Primary pituitary abscess followed by empty sella syndrome in an adolescent girl
Pepene, C.E. and Ilie, I. and Mihu, D. and Stan, H. and Albu, S. and Duncea, I.
Pituitary. 2010; 13(4): 385-389
[Pubmed]
7 Infected rathke cleft cysts: Distinguishing factors and factors predicting recurrence
Tate, M.C., Jahangiri, A., Blevins, L., Kunwar, S., Aghi, M.K.
Neurosurgery. 2010; 67(3): 762-769
[Pubmed]
8 Endoscopic treatment of pituitary abscess: Two case reports and literature review
Ciappetta, P., Calace, A., DŠUrso, P.I., De Candia, N.
Neurosurgical Review. 2008; 31(2): 237-246
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow