Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 8  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4522    
    Printed110    
    Emailed2    
    PDF Downloaded269    
    Comments [Add]    
    Cited by others 18    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2006  |  Volume : 54  |  Issue : 4  |  Page : 366--369

Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population


1 Department of Cardiovascular Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
2 Hemostasis and Thrombosis Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science and PUMC, Beijing, China
3 Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and PUMC, Beijing, China

Correspondence Address:
Shudong Xia
Department of Cardiovascular Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.28107

Rights and Permissions

Background and Aims: Chronic inflammatory process plays an important role in atherothrombosis. Interleukin-1 (IL-1) is one of the key modulators of the inflammatory response and its activity is critically regulated by its receptor antagonist (IL-1Ra). A variable number tandem repeat polymorphism in intron 2 of IL-1Ra gene and a C to T single base polymorphism in the promoter of IL-1β gene (C-511®T) have been reported to affect the levels of IL-1 as well as its antagonist, IL-1Ra. It is also reported in several studies that these polymorphisms are associated with the susceptibility to cardio-cerebral vascular disease. However, data are limited in China. In this article, we studied the relationships between these polymorphisms and the risk of ischemic stroke in China. Materials and Methods: One hundred and twelve patients committed ischemic stroke were compared with 95 demographically matched healthy volunteers. Results: The frequencies of the IL-1Ra 1/1 genotype and IL-1Ra allele 1 (Ra*1 allele) in stroke patients were significantly higher than those in healthy volunteers [93.7% vs. 82.1%, P =0.014; 0.964 vs. 0.905, P =0.007]. No significant differences were found in the IL-1β -511 genotype and the allele distribution between the two groups. Conclusions: Our results implicated that IL-1 gene polymorphism might be associated with the susceptibility to ischemic stroke.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow