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 CASE REPORT
Year : 2007  |  Volume : 55  |  Issue : 4  |  Page : 385--387

Magnetic resonance spectroscopy study in basal ganglia of patients with myoclonic epilepsy with ragged-red fibers


1 Department of Neurology, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan
2 Department of Medical Imaging, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan
3 Vscular and Genomic center, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500, Taiwan

Correspondence Address:
Chin-San Liu
Department of Neurology, Changhua Christian Hospital, 135 Nanhsiao Street, Changhua, 500
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.37096

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Abnormal magnetic resonance spectroscopic (MRS) signals in the basal ganglia may be one of the characteristics in mitochondrial disease. We report MRS study in a family with myoclonic epilepsy with ragged-red fibers (MERRF). Their MRS studies over the basal ganglia revealed decreased N-acetylaspartate/creatine ratio and increased choline/creatine ratio in the four symptomatic members, but normal in the two asymptomatic members. However, negative MRI study was found in all members of this family. Our report suggests that the increased choline/creatine ratio in basal ganglia MRS may be one of the early information to suspect MERRF disease.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow