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LETTER TO EDITOR
Year : 2007  |  Volume : 55  |  Issue : 4  |  Page : 433-434

Scalp and intracranial metastasis from pleomorphic adenocarcinoma of the parotid gland


1 Department of Neurosurgery, G.B. Pant Hospital and Maulana Azad Medical College, New Delhi, India
2 Department of Neuropathology, G.B. Pant Hospital and Maulana Azad Medical College, New Delhi, India
3 Department of Pathology, LNJP and Maulana Azad Medical College, New Delhi, India

Date of Acceptance12-Feb-2007

Correspondence Address:
A K Srivastava
Department of Neurosurgery, G.B. Pant Hospital and Maulana Azad Medical College, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.33305

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How to cite this article:
Srivastava A K, Jagetia A, Tatke M, Khurana N. Scalp and intracranial metastasis from pleomorphic adenocarcinoma of the parotid gland. Neurol India 2007;55:433-4

How to cite this URL:
Srivastava A K, Jagetia A, Tatke M, Khurana N. Scalp and intracranial metastasis from pleomorphic adenocarcinoma of the parotid gland. Neurol India [serial online] 2007 [cited 2020 Jul 12];55:433-4. Available from: http://www.neurologyindia.com/text.asp?2007/55/4/433/33305


Sir,

Adenocarcinoma of the salivary gland is an aggressive tumor with the tendency to metastasize locally or through lymphatics. Intracranial metastasis through hematogenous route from salivary gland malignant tumor is uncommon and most of the reported cases are from the adenocystic carcinoma of the parotid gland. [1] We are reporting a case of scalp and supratentorial cerebral metastasis from pleomorphic adenocarcinoma of the parotid gland, which has never been reported in the English literature.

A 30-year-old man presented with painless swelling scalp in the midline of vertex for two months, progressively increasing weakness of right half of the body, headache and vomiting for one month. He was an operated case of pleomorphic adenocarcinoma of the left parotid gland. Parotidectomy with Type 2 neck dissection and removal of left facial nerve was done two months ago followed by radiotherapy. Neurological examination revealed papilloedema, facial nerve palsy and right side spastic hemiparesis with intact higher mental functions. There was a non-tender, firm immobile swelling in the scalp of about 1.5x1.5 cm size in the midline.

The MRI brain revealed a hetrointense lesion in mid-parasagittal region enhancing brightly on contrast with dural tail, perilesional edema and mass effect. There was an additional mass, approximately 1.2x1.2 cm in size which was also enhancing on gadolinium contrast, arising from the scalp just above the intracranial lesion without any continuity with underlying bone or cerebrum [Figure - 1]. Other hematological and biochemical examination was normal.

Left parietal craniotomy and total excision of intracranial tumor and excision of scalp mass was done. Both the scalp and intracranial tumors were highly vascular. The intracranial tumor had no continuity with the scalp lesion. Intracranial tumor was extra-axial, attached to falx, grayish, firm with well-defined plane of cleavage. Postoperative CT head revealed no residual tumor. The histopathological examination of the scalp and the intracranial mass was consistent with metastasis from the malignant pleomorphic adenoma. Patient was lost in the follow-up.

Adenocarcinoma of the salivary gland is a very aggressive tumor and metastasizes to the lung, bones, liver, choroid and brain. [1],[2] The involvement of brain and scalp is rare and only 11 cases of intracranial metastasis from parotid carcinoma have been reported in the literature, however, all were secondary to adenoid cystic carcinoma of the salivary gland. [3] No case has been reported in the literature, with simultaneous scalp and intracranial metastasis secondary to pleomorphic adenocarcinoma of the parotid gland with sparing of overlying calvaria.

Carcinomatous lesions of the head and neck can extend intracranial via the direct destruction of the skull base, extension along the cranial nerves and branches of the internal carotid artery. Besides these routes, hematogenous spread may occur to the cranium through the external carotid artery, however, is uncommon. Tumors reported to metastasize to the cranium through the branches of the external carotid artery are from the liver, pancreas, thyroid, parotid and uterus, etc. [4],[5] These tumors are highly vascular and show tumor blush angiographically. These tumors may be embolized preoperatively to reduce the blood supply; however, the outcome of head and neck cancer with distant metastasis is poor with a median survival of four to seven months. [6] This is a unique case as both the secondaries were from the same site without involving the bone even when all these structures had common vascular supply by the external carotid artery, possibly because of early presentation of the neurological symptoms.

 
  References Top

1.Hammoud MA, Hassenbusch SJ, Fuller GN, Shi W, Leeds NE. Multiple brain metastases: A rare manifestation of adenoid cystic carcinoma of the parotid gland. J Neurooncol 1996;27:61-4.  Back to cited text no. 1  [PUBMED]  
2.Izzo L, Frati R, Cianfrone F, Sassavannis PG, Costi U, Galati G, et al . Parotid gland cancer: A case report of a primitive adenocarcinoma arising from a multirecurrent pleomorphic adenoma. J Exp Clin Cancer Res 2004;23:153-6.  Back to cited text no. 2    
3.Schwartz RA. Cutaneous metastatic disease. J Am Acad Dermatol 1995;33:161-82.  Back to cited text no. 3  [PUBMED]  
4.Kuratsu J, Murakami M, Uemura S, Ushi Y. Brain and skull metastasis in hepatic or pancreatic cancer: Report of six cases. Neurol Med Chir (Tokyo) 1990;30:476-82.  Back to cited text no. 4    
5.Uchino M, Endo G, Shibata I, Terao H, Kuramitsu T, Kushida Y, et al . Uterine leiomyosarcoma metastasis to the skull: Case report. Neurol Med Chir (Tokyo) 1996;36:469-71.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Schwenter I, Obrist P, Thumbfart W, Sprinzl G. Distant metastasis of parotid tumours. Acta Otolaryngol 2006;126:340-5.  Back to cited text no. 6    


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This article has been cited by
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