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 CASE REPORT
Year : 2008  |  Volume : 56  |  Issue : 2  |  Page : 198--200

Miller-Fisher syndrome associated with chronic lymphocytic leukemia


1 Department of Hematology, Gazi University Faculty of Medicine, Ankara, Turkey
2 Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey

Correspondence Address:
Zeynep Aki
Ögretmenler Cad. 470 Sok. 2/16, 06520 Çukurambar - Ankara
Turkey
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.42003

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Chronic lymphocytic leukemia (CLL) is a frequent hematological malignancy, with meningeal or peripheral nerve infiltrations being the most commonly encountered neurological complications. In this report, we describe a CLL patient with Miller-Fisher syndrome (MFS) who responded to immune modulation with plasmapheresis. A 47-year-old man diagnosed as B-cell CLL admitted with neutropenic fever. He complained of diplopia and numbness of both arms. Neurological examination revealed a bilateral external ophthalmoplegia, dysphagia, dysarthria, mild shoulder girdle muscle weakness and gait ataxia, accompanied by absent tendon reflexes. Nerve conduction studies were indicative of a predominantly axonal sensori-motor peripheral neuropathy. This association of CLL with MFS had not been previously reported in the literature.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow