Atormac
brintellex
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 662  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  » Next article
  » Previous article 
  » Table of Contents
  
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
  »  Article in PDF (754 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

 
  In this Article
 »  References
 »  Article Figures
 »  Article Tables

 Article Access Statistics
    Viewed2799    
    Printed70    
    Emailed0    
    PDF Downloaded138    
    Comments [Add]    
    Cited by others 9    

Recommend this journal

 


 
LETTER TO EDITOR
Year : 2008  |  Volume : 56  |  Issue : 4  |  Page : 482-483

Familial mirror movements over five generations


1 Department of Neurology, Golestan Hospital, Jundishapour University of Medical Sciences, Ahwaz, Iran
2 Clinical Research Center, Golestan Hospital, Jundishapour University of Medical Sciences, Ahwaz, Iran

Date of Acceptance13-Nov-2008

Correspondence Address:
Naser Sharafaddinzadeh
Department of Neurology, Golestan Hospital, Jundishapour University of Medical Sciences, Ahwaz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.44813

Rights and Permissions



How to cite this article:
Sharafaddinzadeh N, Bavarsad R, Yousefkhah M, Aleali AM. Familial mirror movements over five generations. Neurol India 2008;56:482-3

How to cite this URL:
Sharafaddinzadeh N, Bavarsad R, Yousefkhah M, Aleali AM. Familial mirror movements over five generations. Neurol India [serial online] 2008 [cited 2020 Sep 28];56:482-3. Available from: http://www.neurologyindia.com/text.asp?2008/56/4/482/44813


Sir,

Familial mirror movement (MM) is a rare condition and refers to involuntary movements that occur in homologous contralateral muscles during their voluntary (active) movement and are often observed in the upper extremities but rarely in lower extremities.

The case study in question is a large Persian-speaking family from the Isfahan province in the Southeast of Iran with MMs over five generations. In addition, the heredity pattern of the family was delineated and four cases in the family under study were selected and are presented in [Table 1].

To date, this is the only largest family group with MMs that has been reported. Neurological and psychiatric examinations and brain and cervical MRI were normal in the study group; and MMs were determined by electromyography. Another thirteen cases were studied on the basis of their medical histories.

Their family tree was drawn by asking the eldest member of the family regarding the interfamily relationships [Figure 1].

The execution of strictly unilateral motor tasks requires restriction of motor output activity in the M1 contralateral to the voluntary movement. [1] MMs are an interesting but often overlooked neurological soft sign. Persistence of MMs in adult life without any other neurological or behavioral problem as a familial event was noticed by Rasmaussen in 1993. Congenital MM in association with nonfluctuant palpebral ptosis and nocturnal enuresis have been described recently by Ruggieri et al., in 1999. [2] The study carried out by the researchers reports and investigates the largest family group to date with MMs over five generations with 17 affected persons and describes four individuals within this group as case studies [Figure 1]. The term of MM was first applied in 1879 by Earl Nemeyer. But the definition of MM as involuntary, synkinetic mirror reversals of an intended movement of opposite side was coined by Cohen et al., in 1991. [3] Depending on the cause, MM is classified as physiologic ( in a normal infant there is tendency for movements of one limb to be accompanied by similar involuntary movement of opposite limb). This tends to disappear before ten years of age, coincident with myelinization of corpus callosum; and symptomatic or pathological MMs, which is associated with several neurologic conditions such as, agenesis of corpus callosum, basilar invagination of skull, spina bifida occulta Friedrich's ataxia, Kallmann's syndrome, Usher syndrome, phenylketonuria, congenital hemiparesis, diabetes insipidus, mental retardation, CNS insult (tumor, CVA, SAH, trauma), [4] schizophrenia, [5] Parkinson disease, [6] cerebral palsy, and obsessive compulsive disorder. [7]

Familial MM which is characterized by predominant or exclusive movement of hands especially the fingers is normally seen during active movements and rarely during passive movements. The MM will have lesser amplitude than that of voluntary movement, and occasional asymmetry of response mirroring is more evident on one side than the other. The increase in the MM with effort is noticeable early in life and nonprogressive after childhood may be hereditary (often due to autosomal dominance) or sporadic.

The literature regarding this particular phenomenon does not recommend surgery or drug treatment for the soft sign form of MM; however, cases under study have learned to decrease their movements with some motor tricks.

It does advocate that the person stricken with MM should learn to minimize such movements by applying some motor ploys.

The aim of this study was the identification and presentation of the rare form of this soft sign and with due regards to the genealogical tree of the family under study, it seems as if the transmitted form of the disease is autosomally dominant.

 
 » References Top

1.Carson RG. Neural Pathways Medicine: Bilateral interactions between the upper limbs. Brain Res Rev 2005;49:641-62.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]
2.Ruggieri V, Amartino H, Fejerman N. Congenital mirror movements: Three new cases of a rare condition. Rev Neurol 1999;29:731-5.  Back to cited text no. 2  [PUBMED]  
3.Cohen LG, Meer J, Tarkka I, Bierner S, Leiderman DB, Dubinsky RM, et al . Congenital mirror movements: Abnormal organization of motor pathways in two patients. Brain 1991;114:381-403.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Hermesdorfer J, Danek A, Winter T, Marquardt C, Mai N. Persistent Mirror movement: Force and timing of "Mirroring" are Task-dependent. Exp Brain Res 1995;104:126-34.  Back to cited text no. 4    
5.Hoy KE, Georgiou-Karisitianis N, Laycock R, Fitzgerald PB. Using transcranial magnetic stimulation to investigate the cortical origins of motor overflow: A study in schizophrenia and health controls. Psychol Med 2007;37:583-94.  Back to cited text no. 5    
6.Cincotta M, Borgheresi A, Balestrieri F, Giovannelli F, Ragazzoni A, Vanni P, et al . Mechanisms underlying mirror movements in Parkinson's disease: A transcranial magnetic stimulation study. Mov Disord 2006a;21:1019-25.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]
7.Bhattacharya A, Lahiri A. Mirror movement in clinical practice. J Indian Acad Community Med 2002;3:177-81.  Back to cited text no. 7    


    Figures

  [Figure 1]
 
 
    Tables

  [Table 1]

This article has been cited by
1 Welche Ursache haben unwillkürliche Spiegelbewegungen?
Ferdinand Binkofski,Manuel Dafotakis,Cornelius J. Werner,Silvia Maaß,Adrian Danek
InFo Neurologie & Psychiatrie. 2017; 19(6): 28
[Pubmed] | [DOI]
2 Pre-movement planning processes in people with congenital mirror movements
E.A. Franz,Y. Fu
Clinical Neurophysiology. 2017; 128(10): 1985
[Pubmed] | [DOI]
3 Congenital mirror movements: Phenotypes associated with DCC and RAD51 mutations
Elizabeth A. Franz,Rachel Chiaroni-Clarke,Stephanie Woodrow,Kelly A. Glendining,Christine L. Jasoni,Stephen P. Robertson,R.J. McKinlay Gardner,David Markie
Journal of the Neurological Sciences. 2015; 351(1-2): 140
[Pubmed] | [DOI]
4 Congenital Mirror Movements in a New Italian Family
Alfonso Fasano,Matteo Bologna,Ennio Iezzi,Luigi Pavone,Myriam Srour,Francesca Di Biasio,Giovanni Grillea,Guy A. Rouleau,Annie Levert,Fabio Sebastiano,Claudio Colonnese,Alfredo Berardelli
Movement Disorders Clinical Practice. 2014; 1(3): 180
[Pubmed] | [DOI]
5 A novel DCC mutation and genetic heterogeneity in congenital mirror movements
Depienne, C., Cincotta, M., Billot, S., Bouteiller, D., Groppa, S., Brochard, V., Flamand, C., (...), Roze, E.
Neurology. 2011; 76(3): 260-264
[Pubmed]
6 Congenital mirror movements: a clue to understanding bimanual motor control
Cécile Galléa, Traian Popa, Ségolène Billot, Aurélie Méneret, Christel Depienne, Emmanuel Roze
Journal of Neurology. 2011;
[VIEW] | [DOI]
7 Mirror movements in children [Mouvements miroirs de læenfant]
Roze, E. and Billot, S. and Gallea, C. and Meunier, S.
Medecine Therapeutique Pediatrie. 2011; 14(2): 121-125
[Pubmed]
8 Mutations in DCC Cause Congenital Mirror Movements
Srour, M., Rivière, J.-B., Pham, J.M.T., Dubé, M.-P., Girard, S., Morin, S., Dion, P.A., (...), Rouleau, G.A.
Science. 2010; 328(5978): 592
[Pubmed] | [DOI]
9 Familial congenital mirror movements: Report of a large 4-generation family
Srour, M., Philibert, M., Dion, M.-H., Duquette, A., Richer, F., Rouleau, G.A., Chouinard, S.
Neurology. 2009; 73(9): 729-731
[Pubmed]



 

Top
Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow