Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 3836  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
   Next article
   Previous article 
   Table of Contents
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (112 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References

 Article Access Statistics
    Viewed1720    
    Printed94    
    Emailed0    
    PDF Downloaded188    
    Comments [Add]    

Recommend this journal

 


 
INVITED COMMENTARY
Year : 2009  |  Volume : 57  |  Issue : 2  |  Page : 175-176

Invited Commentary


Department of Neurology, Grant Medical College and Sir JJ group of hospitals, Mumbai, India

Date of Acceptance01-Apr-2009

Correspondence Address:
Satish Khadilkar
Room No 110, New Wing, First floor, Bombay Hospital and Medical Research Centre, New Marine Lines, Mumbai
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.51288

Rights and Permissions



How to cite this article:
Khadilkar S. Invited Commentary. Neurol India 2009;57:175-6

How to cite this URL:
Khadilkar S. Invited Commentary. Neurol India [serial online] 2009 [cited 2019 Mar 19];57:175-6. Available from: http://www.neurologyindia.com/text.asp?2009/57/2/175/51288


The article by Pradhan [1] on the description of the diamond sign in dysferlinopathy is refreshing and interesting. In the modern times, medical advances have moved away from the bedside, into laboratories which use complex gadgets to probe the depth of scientific problems. More and more time is being spent by medical practitioners huddled around the radiological view boxes and with instruments, discussing the problems of their 'i patients' from the files, while the real patient gets only a brief and often cursory examination.

In this context, returning to the careful clinical observations, as Dr Pradhan [1] has so elegantly and repeatedly shown, is very helpful. Starting with the valley sign in Duchenne Muscular Dystrophy [DMD], [2],[3] he has been bringing out peculiarities of clinical features of various muscular dystrophies encountered in India. The valley sign is particularly useful in patients of DMD who are examined late in the disease course when the calf hypertrophy has disappeared. The poly hill sign delineates the specific hypertrophy and atrophy of the muscles around the shoulder, helping the diagnosis of Facio scapuloperoneal muscular dystrophy [FSHD]. [4] The shank sign in myotonic dystrophy [4] helps to differentiate it from other myotonic syndromes. The diamond sign recently described by him [6] is a useful indicator of the subgroup of patients with deficiency of dysferlin. The specificity and sensitivity of the sign need further work, as he mentions in the paper. At this stage, perhaps a note needs to be made on the control population which comprises of patients having FSHD and myotonic muscular dystrophy which have a very different pattern of muscular involvement.

It is important to put the role of clinical signs in perspective of molecular mechanisms of disease. The observation of the hip abduction sign in limb girdle muscular dystrophies is an example. Initially, I felt the sign is seen in sarcoglycanopathies alone, [7] only to observe later that this pattern of muscular weakness is shared by more limb girdle muscular dystrophies. The clinical observation is relevant because it points to inherited myopathies, probably dystrophies, narrowing down the differential diagnosis. In some ways, a corollary could be drawn with the hereditary spinocerebellar degenerations and slow eye movements. Slow eye movements direct us to the inherited nature of the process but do not give a specific genotype. The genotype phenotype correlation is proving to be very complex in myopathies and it is well known that one gene can exhibit many phenotypes and vice versa. We can not expect clinical signs to accurately predict the genotype, but they can certainly lead the clinician in the right direction of inquiry and minimization of investigative resources. To this effect these observations by Dr Pradhan have great merit.

 
  References Top

1.Pradhan S. Clinical and magnetic resonance imaging features of 'diamond on quadriceps' sign in dysferlinopathy. Neurol India 2009;57:172-5.  Back to cited text no. 1  [PUBMED]  Medknow Journal
2.Pradhan S. New clinical sign in Duchenne muscular dystrophy. Pediatr Neurol 1994;11:298-300.  Back to cited text no. 2  [PUBMED]  
3.Pradhan S, Mittal B. Infraspinatus muscle hypertrophy and axillary folds wasting as the important signs in Duchenne muscular dystrophy. Clin Neurol Neurosurg 1995;91:134-8.  Back to cited text no. 3    
4.Pradhan S. Poly-hill sign in facioscapulohumeral dystrophy. Muscle Nerve 2002;25:754-5.  Back to cited text no. 4  [PUBMED]  [FULLTEXT]
5.Pradhan S. Shank sign in myotonic dystrophy type-I (DM-I): Utility in differentiation from DM-II and some other common muscular dystrophies. J Clin Neurosci 2007;14:27-32.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]
6.Pradhan S. Diamonds on quadriceps sign in dysferlinopathy. Neurology 2008;70:322.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]
7.Khadilkar SV, Singh RK. Hip abduction sign: A new clinical sign in sarcoglycanopathies. J Clin Neuromusc Dis 2001;3:13-5.  Back to cited text no. 7    




 

Top
Print this article  Email this article
Previous article Next article
Online since 20th March '04
Published by Wolters Kluwer - Medknow