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 BRIEF REPORT
Year : 2009  |  Volume : 57  |  Issue : 4  |  Page : 460--463

Pyridoxine-dependent seizures: 10-year follow-up of eight cases


Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman

Correspondence Address:
Roshan Koul
Senior Consultant and Child Neurologist, SQUH. BW1,Muscat
Oman
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.55595

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Eight children with pyridoxine-dependent seizures (PDS) were seen over a period of 10 years. Of those children, 6 are on regular follow-up. Four of the children were seen in one family. All the patients presented with refractory seizures, mainly neonatal status epilepticus. Though PDS is a rare condition, it must be considered in all cases with refractory seizures, particularly in childrens younger than 3 years. When confirming a diagnosis, oral pyridoxine is as effective as intravenous pyridoxine.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow