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LETTER TO EDITOR
Year : 2009  |  Volume : 57  |  Issue : 6  |  Page : 807-808

First do no harm - A case of limb shaking TIA


Department of Neurology, Lilavati Hospital and Research Center, Bandra (West), Mumbai - 400 050, India

Date of Acceptance09-Mar-2009
Date of Web Publication30-Jan-2010

Correspondence Address:
Sweta P Adatia
Department of Neurology, Lilavati Hospital and Research Center, Bandra (West), Mumbai - 400 050
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.59486

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How to cite this article:
Adatia SP, Chauhan VS, Hastak SM. First do no harm - A case of limb shaking TIA. Neurol India 2009;57:807-8

How to cite this URL:
Adatia SP, Chauhan VS, Hastak SM. First do no harm - A case of limb shaking TIA. Neurol India [serial online] 2009 [cited 2020 May 31];57:807-8. Available from: http://www.neurologyindia.com/text.asp?2009/57/6/807/59486


Sir,

A 75-year-old gentleman presented to us with the chief complaint of weakness of right lower limb. The same morning, patient complained of shaking of both lower limbs approximately in the frequency of 3-4 Hz and particularly the symptoms were present when he stood. The shaking stopped as he lied down. There was no marching of the involuntary movements. He was on medications for diabetes mellitus and hypertension. He was assessed elsewhere in the morning and the involuntary movements were attributed to seizure and was advised EEG which was normal. His blood pressure (BP) was 220/110 mmHg and he was given 10 mg of nimodipine by the family physician. He was started on oral phenytoin. When he presented to us, he had difficulty in lifting the right lower limb. He was dragging the right lower limb while walking. His neurological examination revealed right crural monoplegia with motor power of 3/5. Rest of the neurological examinations was normal. Auscultation of carotids revealed left carotid bruit. His BP was 120/90 mmHg.

Magnetic resonance angiography (MRA) of the brain revealed watershed infarcts in both cerebral hemispheres in the anterior cerebral artery and middle cerebral artery (ACA-MCA) regions, and complete occlusion of right internal carotid artery (ICA) and severe stenosis of left carotid artery [Figure 1] and [Figure 2]. His carotid duplex showed complete absence of flow in the right carotid artery and left carotid artery showed 60-70% stenosis.

The patient was treated conservatively with antiplatelets as he denied cerebral angiography for possible reperfusion intervention. At times, keeping the blood pressure on higher side can benefit such patients from further progression, but with the background of atherosclerotic diseases like diabetes and hypertension, it poses a great risk to myocardium and kidneys.

Miller Fisher first described a temporary limb shaking syndrome (LSS) associated with carotid stenosis in 1962; since then, the diagnosis has been reported regularly though only 48 cases have been recorded so far as per our review and rather than being rare, it seems to be a misrecognized syndrome. [1] However bilateral shaking of lower extremities is a very rare presentation. [2] The clinical features of LSS comprise a group of rhythmic or arrhythmic involuntary hyperkinesias affecting the hand, arm, leg, hand-arm, or hand-arm-leg unilaterally. They can be very easily be mistaken for focal seizures though there is no jacksonian march and there is no involvement of the face, as what happened in our patient. Patients describe these movements as shaking, jerking, twitching, or trembling. Associated symptoms may include ataxia, myoclonus, dystonic limb posturing, and  Parkinsonism More Details. [3] These symptoms are often brought out by postural change and at times relieved by sitting or lying down.

The exact mechanism of LSS is unclear, though it can be postulated to be due to the 'hypoperfusion' theory in which the carotid stenosis leads to decreased blood supply to critical watershed territories in the brain. This is further supported by the fact that these movements are provoked by maneuvers that cause cerebral hypoperfusion. A lot of studies have shown the hemodynamic failure as the underlying cause of the LSS. EEGs have failed to show epileptiform activity, although some patients do show contralateral slowing. [4] The most striking feature of LSS is severe internal carotid artery stenosis.

In patients with stenosis of carotid arteries, carotid endarterectomy is the procedure of treatment of choice. [5] However with the improved technology of stents and distal protection devices, endovascular treatment offers a favorable role in select cases. [6] Acute carotid occlusions have been stented following angioplasty showing favorable results but further studies are required to make it a standard practice. Thus, identification of LSS and detection of underlying carotid artery disease is crucial for prevention of stroke.

 
  References Top

1.Fisher CM. Concerning recurrent transient cerebral ischemic attacks. Can Med 1962;86:1091-9.  Back to cited text no. 1      
2.Galvez-Jamenez, Hanson MR, Hangreave MJ, Peirut P. Transient ischemic attacks and paroxysmal dyskinesia: An under-recognized association. Adv Neurol 2002;89:421-32.  Back to cited text no. 2      
3.Kowacz PA, Troiano AR, Mendonca CT, Teive HA, Werneck LC. Caraotid transient ischemic attacks presenting as limb-shaking syndrome. Arq Neuropsiquiatr 2004;62:339-41.  Back to cited text no. 3      
4.Ali S, Khan MA, Khealani B. Limb-shaking transient ischemic attacks: Case report and review of literature. BMC Neurol 2006.  Back to cited text no. 4      
5.Tatemichi TK, Young WL, Prohovnik I, Gitelman DR, Correll JW, Mohr JP. Perfusion insufficiency in limb-shaking transient ischemic attacks. Stroke 1990;21:341-7.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  
6.Yadav JS, Wholey MH, Kuntz RE, Fayad P, Katzen BT, Mishkel GJ, et al. Protected carotid-artery stenting versus endarterectomy in high risk patients. N Engl J Med 2004;351:1493-501.  Back to cited text no. 6      


    Figures

  [Figure 1], [Figure 2]

This article has been cited by
1 Internal Carotid Artery Stenosis Presenting with Limb Shaking TIA
Awad Javaid,Mostafa Alfishawy
Case Reports in Neurological Medicine. 2016; 2016: 1
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2 Limb-shaking transient ischemic attack responsive to nimodipine: A case report
Li, L.-Y. and Yu, C.-Y. and Huang, L. and Wang, Y.
Neurology Asia. 2012; 17(4): 353-356
[Pubmed]



 

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