Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 1698  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3270    
    Printed158    
    Emailed0    
    PDF Downloaded127    
    Comments [Add]    
    Cited by others 3    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2010  |  Volume : 58  |  Issue : 1  |  Page : 53--57

Parkinson's disease: Functional changes in frontal and parietal cortex using 18 F- fluoro-deoxy glucose positron emission tomography/computed tomography


1 Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan; Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, China
2 Qianfoshan Hospital Affiliated to Shandong University, Jinan, China
3 Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, China
4 Department of Radiology, Provincial Hospital Affiliated to Shandong University, Jinan, China

Correspondence Address:
Shuwei Liu
Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan - 250 012
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.60397

Rights and Permissions

Background : In Parkinson's disease (PD) there is increasing evidence to suggest motor function changes of the cerebral cortex occur in addition to the pathological changes in the extrapyramidal system. Aims : To explore the functional changes in the frontal and parietal cortex in PD cat model. Settings and Design : Twenty-four healthy male cats were divided into four animal model groups with the injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), and one control group. Materials and Methods : Cats in both the animal model and control groups were observed for the behavioral changes. They were also examined by 18 F-fluoro-deoxy glucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT). Region of Interest (ROI) was determined by 18 F-FDG intensity and semi-quantitative analysis was employed after detecting the standard absorption value (SUV). Statistical Analysis : Statistical significance was evaluated by ANOVA. Results : Compared to control group, the 18 F-FDG intensity and SUV were found normal on both the sides of frontal and parietal cortex in the PD models on the second day (P > 0.05), and on the fifth day, they were reduced significantly on both the sides of frontal cortex exclusively (P < 0.05). Moreover on the eighth day, the SUV of both frontal cortexes was reduced, while it was increased in both parietal cortex (P < 0.05). Finally on the eleventh day, the SUV remained stable in both the frontal cortex, and was back to normal level in both the parietal cortex. Conclusions : Functional disorders exist in the frontal cortex of PD animals and aggravate with time. Transient functional enhancement in the parietal cortex of PD cats might be a compensation for the dysfunction of frontal cortex.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow