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 ORIGINAL ARTICLE
Year : 2010  |  Volume : 58  |  Issue : 2  |  Page : 195--200

db-Cyclic adenosine monophosphate promotes axon regeneration and motor function recovery in cerebral ischemia-reperfusion rats


Department of Neurology, The Second Affiliated Hospital of Chongqing University of Medical Sciences, Chongqing 400010, China

Correspondence Address:
Changqing Li
Department of Neurology, 2nd Hospital, Chongqing University of Medical Sciences, Chongqing-400 010
China
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Source of Support: The Foundation of the Natural Science Foundation of Chongqing city (grant No. 2004-54-8, Conflict of Interest: None


DOI: 10.4103/0028-3886.63786

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Background: There is no effective axon regeneration in adult mammalians. Objective: To investigate the effects of dual-acid cyclic adenosine monophosphate (db-cAMP) on the axon regeneration, motor function recovery and RhoA signal pathway in cerebral ischemia-reperfusion rats, and to explore the possible clinical application and mechanism. Materials and Methods: Middle cerebral artery ischemia-reperfusion model was established by nylon monofilament occlusion method in 105 Sprague-Dawley (SD) rats. Semi-quantitative Western blot analysis was used to assess protein expression level of growth-associated protein-43 (GAP-43) and RhoA. Montoya staircase test score was used to test the motor function of affected forelimb. Results: Compared to the ischemia group, the staircase test score in the db-cAMP group was increased significantly at 30-day (P < 0.05), and GAP-43 protein expression in the db-cAMP group was enhanced significantly at 7-day and 14-day (P < 0.05), and RhoA protein expression in the db-cAMP group was decreased significantly between 24 h to 14-day (P < 0.01). Conclusion: These results show that db-cAMP can promote axon regeneration and the recovery of motor function by inhibiting RhoA signal pathway.






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