Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 729  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4755    
    Printed170    
    Emailed0    
    PDF Downloaded92    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2010  |  Volume : 58  |  Issue : 4  |  Page : 530--536

Protective effects of the calcium-channel blocker flunarizine on crush injury of sciatic nerves in a rat model


1 Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing- 210 029, China
2 Department of Pathology, Changzhou Tumor Hospital, Changzhou- 213005, China
3 Department of Neurotoxicology, Nanjing Medical University, Nanjing- 210029, China
4 Department of Pathology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing- 210018, China
5 Department of Statistics, Nanjing Medical University, Nanjing- 210029, China

Correspondence Address:
Jin-Rong Tang
Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing - 210 029
China
Login to access the Email id

Source of Support: Medical Research Council, Conflict of, Conflict of Interest: None


DOI: 10.4103/0028-3886.68665

Rights and Permissions

Background : Neural damage can be mitigated by calcium-channel blockers (CCBs). However, the mechanism of action of CCBs is not yet fully understood. Objective : To investigate the mechanism of action and efficacy of CCB, flunarizine in restoring neural function after crush injury to the nerves Materials and Methods : The sciatic nerves of rats were crushed using pincers to establish the model for crush injury. Two hundred and eighty-eight Sprague-Dawley (SD) rats were randomly divided into sham-operated, saline, and low-dose flunarizine and high-dose flunarizine (FI and FII) groups. The expression of the protein c-fos in the dorsal root ganglia (DRG) after crush injury to the sciatic nerves was investigated by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blot. The effect of flunarizine on c-fos expression and its efficacy in restoring neural function was evaluated. Results : The c-fos messenger ribonucleic acid (mRNA) and protein expression in FI and FII groups was significantly lower than in the saline group and was the least in the FII group. Nerve-conduction velocity was increased in the order of: saline < FI< FII< sham-operated. There was no significant difference in the nerve-conduction velocity in the sham-operated and FII groups (P>.05). Conclusions : When administered after crush injury to peripheral nerves, flunarizine may protect neurons with lesions from further damage and improve neural function by downregulating c-fos expression.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow