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 CASE REPORT
Year : 2010  |  Volume : 58  |  Issue : 5  |  Page : 778--780

Malignant prolactinoma: A rare case report


1 Department of Pathology, Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), Ahmedabad, Gujarat, India
2 Department of Neurosurgery, Gujarat Cancer and Research Institute (M. P. Shah Cancer Hospital), Ahmedabad, Gujarat, India

Correspondence Address:
Priti Trivedi
Room #412, Department of Pathology, The Gujarat Cancer and Research Institute, NCH Campus, Asarwa, Ahmedabad - 380 016, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.72205

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Pituitary carcinomas are rare adenohypophyseal tumors with cerebrospinal or extracranial metastasis. None of the histologic findings distinguish pituitary adenoma from carcinoma. We describe clinico-pathological and immunohistological features of malignant prolactinoma. The patient initially presented with a prolactin-secreting pituitary adenoma. The tumor showed aggressive clinical course presenting with repeated recurrences and eventually metastasized to multiple bones. MIB-1 and p53 labeling indices were also compared in primary adenoma, recurrent invasive adenoma and metastatic tumor.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow