Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 3046  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
  »  Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
  »  Article in PDF (638 KB)
  »  Citation Manager
  »  Access Statistics
  »  Reader Comments
  »  Email Alert *
  »  Add to My List *
* Registration required (free)  

 
  In this Article
 »  References
 »  Article Figures

 Article Access Statistics
    Viewed2028    
    Printed55    
    Emailed2    
    PDF Downloaded29    
    Comments [Add]    
    Cited by others 4    

Recommend this journal

 


 
Table of Contents    
LETTER TO EDITOR
Year : 2011  |  Volume : 59  |  Issue : 4  |  Page : 640-641

Massive subarachnoid pneumocephalus after a stereotactic brain biopsy


Department of Neurosurgery, Hospital Italiano de Buenos Aires, Italy

Date of Submission11-Mar-2011
Date of Decision11-Mar-2011
Date of Acceptance12-Mar-2011
Date of Web Publication30-Aug-2011

Correspondence Address:
E Goldschmidt
Department of Neurosurgery, Hospital Italiano de Buenos Aires
Italy
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.84362

Rights and Permissions



How to cite this article:
Goldschmidt E, Landriel F, Bendersky D, Ajler P, Ciraolo C, Carrizo A. Massive subarachnoid pneumocephalus after a stereotactic brain biopsy. Neurol India 2011;59:640-1

How to cite this URL:
Goldschmidt E, Landriel F, Bendersky D, Ajler P, Ciraolo C, Carrizo A. Massive subarachnoid pneumocephalus after a stereotactic brain biopsy. Neurol India [serial online] 2011 [cited 2019 Sep 15];59:640-1. Available from: http://www.neurologyindia.com/text.asp?2011/59/4/640/84362


Sir,

Image-guided stereotactic brain biopsy (SBB) is a common and generally safe procedure with a morbidity of 3-5% and a mortality of 0-7%. [1] The most frequent complications include hemorrhage and infection. Pneumocephalus is a common consequence of craniotomies in neurosurgical practice [2] but not following SBB. We could not find a case of tension pneumocephalus (TP) following SBB in the review of English literature.

A 28-year-old male with HIV infection, presented with gradually progressing right lower limb weakness of 1 week duration. Physical examination demonstrated right dismetria and right mild crural weakness with diminished reflexes. Magnetic resonance imaging (MRI) of brain showed lesions in the left thalamus-capsular area and in the splenium of the corpus callosum, with high signal intensity on T2-weighted images and no contrast enhancement or mass effect [Figure 1]. Blood and cerebrospinal fluid (CSF) testing for toxoplasmosis, CMV, and EBV serology were negative. A SBB of the thalamus-capsular lesion was performed. No complications during the postoperative period were observed, and the patient was discharged 24 h after the surgical procedure. The histological diagnosis of the biopsy samples was primary B-cell central nervous system lymphoma. He was started on intrathecal methrotexate treatment. Two weeks after discharge the patient was readmitted with altered consciousness, severe headache, expressive aphasia, and increase in right crural weakness. Physical examination revealed a dehiscent incision scar with necrotic tissue and a scalp defect above the burr hole. Brain computerized tomography (CT) scan and MRI showed massive ventricular and subarachnoid pneumocephalus, both "Mount Fuji" and the "Air Bubbles" signs were present. There were no changes in the previous lesions [Figure 2]. CSF examination was normal. The wound was debrided and closed under local anesthesia. The wound healed completely. The patient's symptoms gradually resolved and was discharged 2 weeks after the admission. Repeat CT scan and MRI showed an expanded brain and complete reabsorption of the pneumocephalus.
Figure 1: Preoperative findings and Postoperative CT scan. T1 and T2 axial-weighted images (a and b) show the two lesions with no mass effect or contrast enhancement, (c) a sagital view, the corpus callosum lesion can be seen. (d) The postoperative CT scan with an air bubble in the biopsy site and bellow the burr hole

Click here to view
Figure 2: Subarachnoid pneumocephalus and pneumoventricle. (a-c) A large volume of air scattered throughout the subaachnoid space, ventricles and cisterns, Mount Fuji, and air bubble signs can be seen. (d) A communication between the brain and the skin at the site of the incision which allowed air into the skull

Click here to view


Symptomatic late-onset pneumocephalus is extremely unusual following stereotactic biopsy. No such complication was documented in more than 7000 procedures including our own. [1],[3] Late pneumocephalus related to surgery is an unusual finding and is often associated with the presence of a skull or dura defect and a negative intracranial pressure gradient, most of the times as a consequence of a CSF leak, shunts, or lumbar puncture. [4] In this patient, there was a communication between atmosphere and cranial cavity because of wound dehiscence and negative pressure gradient resulted because of repeated lumbar punctures for giving intrathecal chemotherapy treatment. Treatment of this condition should be directed at closing the communication with the atmosphere that provides the valve mechanism. [5]

 
 » References Top

1.Hall WA. The safety and efficacy of stereotactic biopsy for intracranial lesions.Cancer 1998;82:1749-55.  Back to cited text no. 1
    
2.Sprague A, Poulgrain P. Tension pneumocephalus: A case report and literature review. J Clin Neurosci 1999;6:418-24.  Back to cited text no. 2
    
3.Landriel F, Hem S, Hasdeu S, Kitroser M, Peña L, Ajler P, et al. Biopsia Estereotaxica cerebral guiada tomográficamente. Análisi de una serie de 192. Rev Argent Neuroc 2008;22:110.  Back to cited text no. 3
    
4.Schirmer CM, Heilman CB, Bhardwaj A. Pneumocephalus: Case Ilustrations and Review. Neurocrit Care 2010;13:152-8.  Back to cited text no. 4
    
5.Sankhlas S, Khan GM, Khan MA, Delayed tensión pneumocephalus: A rare complication of shunt surgery. Neurol India 2004;52:401-2.  Back to cited text no. 5
    


    Figures

  [Figure 1], [Figure 2]

This article has been cited by
1 Construction andin vitrotesting of a cellulose dura mater graft
Ezequiel Goldschmidt,Maximiliano Cacicedo,Sebastián Kornfeld,Marina Valinoti,Marcelo Ielpi,Pablo M. Ajler,Claudio Yampolsky,Jorge Rasmussen,Guillermo R. Castro,Pablo Argibay
Neurological Research. 2016; 38(1): 25
[Pubmed] | [DOI]
2 Assessing the role of selected growth factors and cytostatic agents in anin vitromodel of human dura mater healing
Ezequiel Goldschmidt,Marcelo Ielpi,Monica Loresi,Maximiliano Dćadamo,Diego Giunta,Antonio Carrizo,Pablo Ajler,Claudio Yampolsky,Pablo Argibay
Neurological Research. 2014; 36(12): 1040
[Pubmed] | [DOI]
3 A new model for dura mater healing: human dural fibroblast culture
Ezequiel Goldschmidt,Santiago Hem,Pablo Ajler,Marcelo Ielpi,Monica Loresi,Diego Giunta,Antonio Carrizo,Claudio Yampolsky,Pablo Argibay
Neurological Research. 2013; 35(3): 300
[Pubmed] | [DOI]
4 A new model for dura mater healing: Human dural fibroblast culture
Goldschmidt, E. and Hem, S. and Ajler, P. and Ielpi, M. and Loresi, M. and Giunta, D. and Carrizo, A. and Yampolsky, C. and Argibay, P.
Neurological Research. 2013; 35(3): 300-307
[Pubmed]



 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow