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 TOPIC OF THE ISSUE: REVIEW ARTICLE
Year : 2011  |  Volume : 59  |  Issue : 5  |  Page : 700--706

Multifocal motor neuropathy


Johns Hopkins University School of Medicine, Baltimore, MD, USA

Correspondence Address:
Vinay Chaudhry
Johns Hopkins University School of Medicine, JHOC 5072 A, 601 North Caroline Street, Baltimore, MD
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.86544

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Multifocal motor neuropathy (MMN) is a unique disorder characterized by slowly progressive, asymmetric, distal and upper limb predominant weakness without significant sensory abnormalities. Electrophysiology is crucial to the diagnosis, revealing the hallmark partial conduction block. MMN is considered immune mediated due to the association with anti-GM1 antibodies and the response to immunomodulatory treatment. It is paramount to recognize MMN from other motor neuronopathies or peripheral neuropathies as it is treatable. Advances in pathogenesis, clinical features, electrophysiology, diagnostic studies and treatment are reviewed. References for this review were identified from literature search on Pubmed limited to dates from 1988 to 2011. Papers were selected if relevant to the review topic and published in English.






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Online since 20th March '04
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