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Year : 2011  |  Volume : 59  |  Issue : 5  |  Page : 748--752

Multimodal approach in the surgical treatment of refractory epilepsy associated with tuberous sclerosis complex: A series of three cases

Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China

Correspondence Address:
Jianguo Xu
Department of Neurosurgery, West China Hospital of Sichuan University, No. 37 Guoxue Road, Chengdu - 610 041
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.86553

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We describe the surgical treatment of tuberous sclerosis complex (TSC)-related refractory epilepsy in three patients. All three had multiple daily seizures, and each had more than three cortical tubers. High-resolution magnetic resonance imaging, ictal and interictal scalp electroencephalogram (EEG), positron emission tomography, magnetoencephalography as well as acute and intracranial video-EEG were used to identify the epileptogenic tubers. After localization, five cortical tubers (two in the right temporal lobe in patient 1; one each in the left frontal and temporal lobes in patient 2; and one in the right frontal lobe in patient 3) were resected. At minimum follow-up of 13 months (range, 13-35 months), patient 3 had seizure remission; patient 2 had only rare seizures; while patient 1 had 60% reduction in seizure frequency. Successful epilepsy surgery is possible in patients of TSC with multiple tubers using the multimodal approach.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow