Atormac
Neurology India
Open access journal indexed with Index Medicus
  Users online: 1283  
 Home | Login 
About Current Issue Archive Ahead of print Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (989 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References
   Article Figures

 Article Access Statistics
    Viewed2344    
    Printed61    
    Emailed2    
    PDF Downloaded40    
    Comments [Add]    
    Cited by others 1    

Recommend this journal

 


 
Table of Contents    
LETTER TO EDITOR
Year : 2011  |  Volume : 59  |  Issue : 5  |  Page : 767-768

Magnetic resonance imaging and diffusion tensor imaging in primary lateral sclerosis


Department of Neurology, The First Affiliated Hospital of China Medical University, China

Date of Submission23-Jul-2011
Date of Decision24-Jul-2011
Date of Acceptance29-Jul-2011
Date of Web Publication22-Oct-2011

Correspondence Address:
Xiu-Li Shang
Department of Neurology, The First Affiliated Hospital of China Medical University
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.86560

Rights and Permissions



How to cite this article:
Qiu JT, Shang XL. Magnetic resonance imaging and diffusion tensor imaging in primary lateral sclerosis. Neurol India 2011;59:767-8

How to cite this URL:
Qiu JT, Shang XL. Magnetic resonance imaging and diffusion tensor imaging in primary lateral sclerosis. Neurol India [serial online] 2011 [cited 2018 Sep 22];59:767-8. Available from: http://www.neurologyindia.com/text.asp?2011/59/5/767/86560


Sir,

Primary lateral sclerosis (PLS) is a slowly progressive pure upper motor-neuron degenerative disorder of unknown etiology, and is associated with longer survival. [1] Recent studies suggest that magnetic resonance imaging (MRI), voxel-based diffusion tensor imaging (DTI) and tract tracking could be used to objectively document upper motor-neuron degeneration in PLS. We report the MRI and DTI features in a typical patient who met the clinical definite criteria for PLS.

A 32-year-old man presented with progressive difficulty in walking and standing up of over 3 years duration. His previous medical history was unremarkable and there was no family history of similar illness. Neurological examination revealed spasticity in all the four limbs, more so in the lower limbs, slight motor weakness in the lower limbs but no atrophy, markedly exaggerated deep tendon reflexes with bilateral Hoffmann and Babinski and spastic gait. MRI of the brain revealed hypointense signals on T1-weighted and hyperintense signals on T2-weighted sequences [Figure 1]a limited to the bilateral symmetrical corticospinal tracts (CST) involving the subcortical white matter below the precentral gyrus, posterior limbs of the internal capsule (PLIC), cerebral peduncles, pons and medulla oblongata. DTI exhibited significantly reduced fractional anisotropy (FA) values in these regions. Besides, FA values in some other extramotor matter including genu interal capsule, body of fornix, corpus callosum were slightly lower. Furthermore, abnormally decreased color of the CST at the PLIC was observed on anisotropy map with directional color [Figure 1]b. Diffusion tensor tractography (DTT, [Figure 1]c and d) showed severe depletion in the CST. Electrodiagnostic studies showed lower amplitude compound motor action potentials. The patient was positive for serology of hepatitis B surface antigen and hepatitis B virus-DNA.
Figure 1: (a) T2-weighted image revealed demyelination in the posterior limbs of the internal capsule (PLIC). (b) Color map revealed decreased color of the corticospinal tracts (CST) at the PLIC. (c) Tract tracking showed bilateral damaged and sparse CST (design regions of interest in the PLIC). (d) Fiber tract in right PLIC, caudal part of which is CST, showed sere depletion

Click here to view


The existence of PLS as a distinct disease entity has been a contentious issue since its initial description. [1] Currently, there is no defining test or disease marker and the diagnosis is based on clinical criteria proposed by Pringle. [2] Previous study provided evidence that degeneration in PLS is not restricted to the upper motor neurons but also affects the lower motor neurons. However, the degree and stability of lower motor neuron involvement appears to be much less-extensive than in amyotrophic lateralizing sclerosis (ALS). [3] MRI, although neither sensitive nor specific for PLS, is of diagnostic valuable in PLS patients grade more than 3 disease. [4] DTI is an MRI technique that characterizes the diffusion properties of water molecules in vivo. [5] Decreased values of FA indicates axonal degeneration. [6] DTT is applied to reconstruct specific major white matter tract such as CST. [7] FA is more sensitive than DTT of the CST. [8] In our patient, there was extensive FA reduction of various extramotor white matter in addition to the upper motor neuron, similar to the report by Maaike. [8] We suggest advanced neuroimaging techniques in patients with clinical diagnosis of PLS to support the diagnosis.

 
  References Top

1.Singer MA, Statland JM, Wolfe GI, Barohn RJ. Primary lateral sclerosis. Muscle Nerve 2007;35:291-302.  Back to cited text no. 1
[PUBMED]  [FULLTEXT]  
2.Pringle CE, Hudson AJ, Munoz DG, Kiernan JA, Brown WF, Ebers GC. Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria. Brain 1992;115:495-520.  Back to cited text no. 2
[PUBMED]  [FULLTEXT]  
3.Le Forestier N, Maisonobe T, Spelle L, Lesort A, Salachas F, Lacomblez L, et al. Primary lateral sclerosis: Further clarification. J Neurol Sci 2001;185:95-100.  Back to cited text no. 3
[PUBMED]  [FULLTEXT]  
4.Peretti-Viton P, Azulay JP, Trefouret S, Brunel H, Daniel C, Viton JM, et al. MRI of the intracranial corticospinal tracts in amyotrophic and primary lateral sclerosis. Neuroradiology 1999;41:744-9.  Back to cited text no. 4
[PUBMED]  [FULLTEXT]  
5.Wang S, Melhem ER. Amyotrophic lateral sclerosis and primary lateral sclerosis: The role of diffusion tensor imaging and other advanced MR-based techniques as objective upper motor neuron markers. Ann N Y Acad Sci 2005;1064:61-77.  Back to cited text no. 5
[PUBMED]  [FULLTEXT]  
6.Le Bihan D, Mangin JF, Poupon C, Clark CA, Pappata S, Molko N, et al. Diffusion tensor imaging: Concepts and applications. J Magn Reson Imaging 2001;13:534-46.  Back to cited text no. 6
[PUBMED]  [FULLTEXT]  
7.Wakana S, Jiang H, Nagae-Poetscher LM, van Zijl PC, Mori S. Fiber tract-based atlas of human white matter anatomy. Radiology 2004;230:77-87.  Back to cited text no. 7
[PUBMED]  [FULLTEXT]  
8.van der Graaff MM, Sage CA, Caan MW, Akkerman EM, Lavini C, Majoie CB, et al. Upper and extra-motoneuron involvement in early motoneuron disease: A diffusion tensor imaging study. Brain 2011;134:1211-28.  Back to cited text no. 8
[PUBMED]  [FULLTEXT]  


    Figures

  [Figure 1]

This article has been cited by
1 "wine-glass appearance" of pyramidal tracts in a patient with primary lateral sclerosis
Paliwal, V.K., Rahi, S.K., Singh, P., Gupta, R.K.
Neurology India. 2012; 60(1): 110-111
[Pubmed]



 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow