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Table of Contents    
Year : 2011  |  Volume : 59  |  Issue : 6  |  Page : 945

Encephalopathy as an initial symptom of rhabdomyolysis: A commentary

Department of Medicine, B. J. Medical College, Pune, India

Date of Submission10-Nov-2011
Date of Decision10-Nov-2011
Date of Acceptance21-Nov-2011
Date of Web Publication2-Jan-2012

Correspondence Address:
Rishi V Lohiya
Department of Medicine, B. J. Medical College, Pune
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.91401

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How to cite this article:
Lohiya RV. Encephalopathy as an initial symptom of rhabdomyolysis: A commentary. Neurol India 2011;59:945

How to cite this URL:
Lohiya RV. Encephalopathy as an initial symptom of rhabdomyolysis: A commentary. Neurol India [serial online] 2011 [cited 2020 Feb 28];59:945. Available from:


I read the article by Zheng et al., [1] with great interest. In this article the authors have presented a patient with encephalopathy and rhabdomyolysis and proposed that the encephalopathy is secondary to rhabdomyolysis. However, there are many factors which are not in favor of this diagnosis. A short history of five hours before admission and no preceding symptoms, maximum neurological deficit at the onset not coinciding with maximum creatine phosphokinase (CPK) levels and rapid improvement in neurological symptoms but persistent CPK rise contradicts the diagnosis. Further there is no definite sufficient preceding cause to explain the etiology for rhabdomyolysis. Possible etiology can be viral encephalitis with rhabdomyolysis. [2] Rarely, cerebrospinal fluid studies may be normal [3] except for viral nucleic acid assays. Thus further workup in this case might have defined the etiology for this encephalitis and rhabdomyolysis.

 » References Top

1.Zheng Z, Han X, Chang Y, Liu S. Encephalopathy as an initial symptom of rhabdomyolysis. Neurol India 2011;59:746-6.  Back to cited text no. 1
2.Davis JS, Bourke P. Rhabdomyolysis associated with dengue virus infection. Clin Infect Dis 2004;38:e109-11.  Back to cited text no. 2
3.SP, Chow CC, Smith SW, Marfin AA, O'Leary DR, Campbell GL. Rhabdomyolysis in patients with west nile encephalitis and meningitis. Vector Borne Zoonotic Dis 2005;5:252-7.  Back to cited text no. 3

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Zheng, Z., Han, X., Chang, Y., Liu, S.
Neurology India. 2011; 59(6): 946


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