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|LETTER TO EDITOR
|Year : 2012 | Volume
| Issue : 3 | Page : 368-369
A Gupta, G Shukla, V Goyal, A Srivastava, M Behari
Department of Neurology, All India Institute of Medical Sciences, Ansar Nagar, New Delhi, India
|Date of Submission||12-Apr-2012|
|Date of Decision||12-Apr-2012|
|Date of Acceptance||10-Jun-2012|
|Date of Web Publication||14-Jul-2012|
Department of Neurology, All India Institute of Medical Sciences, Ansar Nagar, New Delhi
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Gupta A, Shukla G, Goyal V, Srivastava A, Behari M. Authors' reply. Neurol India 2012;60:368-9
We appreciate the points raised in this letter  and would like to clarify regarding the two main issues raised in the letter.
Firstly, we do accept that given the retrospective nature of our study; many patients included had been seen several years back, and the new AASM guidelines were not strictly adhered to during polysomnography recordings. Since uniform data for periodic limb movements (PLMs) could not be obtained for all patients, we did refrain from pooling this data and reporting it. We do acknowledge that details about the PLMs and the PLM with arousal index could have added much more value to the paper.
Secondly, the point about assessing hypocretin I levels in cerebrospinal fluid (CSF) of patients and their first-degree relatives is also well received. While kits for the same had been procured at the neurobiochemistry laboratory at our center, proper standardization could not be established and estimations were found to be grossly variable and inaccurate. At present, this investigation is unavailable at any other center in the country. However, we do have preserved CSF samples of all patients reported and, at a future date, whenever reliable estimation of hypocretin levels is available, these samples can be tested.
| » References|| |
|1.||Halit Y, Hakan T, Güney SM. Clinical and polysomnographic characteristics in 20 North Indian patients with narcolepsy: A seven-year experience from a neurology service. Neurol India 2012;60:368. |