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 ORIGINAL ARTICLE
Year : 2013  |  Volume : 61  |  Issue : 1  |  Page : 40--44

Three risk factors for WHO grade II and III meningiomas: A study of 1737 cases from a single center


Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

Correspondence Address:
Shu Jiang
Department of Neurosurgery, West China Hospital, Sichuan University, NO. 37. Guoxue Alley, Chengdu, Sichuan Province, 610041
China
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Source of Support: This work was supported by the National Natural Science Foundation of China (Grant No. 81072077) and Foundation of Science and Technology Department of Sichuan Provience (Grant NO.2010SZ0160), Conflict of Interest: None


DOI: 10.4103/0028-3886.107928

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Background: Meningiomas account for 35.5% of central nervous system (CNS) tumors, of which 21-37.8% are atypical or anaplastic/malignant. High-grade meningiomas have higher rates of recurrence and worse outcome than grade I/II meningiomas. Thus, it is of importance to assess the tumor biology before treatment initiation. Materials and Methods: This study reviewed 1737 patients with histologically confirmed meningioma at a single institution. Meningiomas were classified according to World Health Organization (WHO) 2007 grading and the location of the tumor was confirmed from the operation records and preoperative imaging. Univariate and multivariate logistic regression were used to analyze the potential risk factors for high-grade pathology. Results: Young men and pediatric patients were less likely to have meningioma, but they had high-grade meningioma. Tumors originated from non-skull base and lateral intracranial are more likely to be grade II/III meningioma. Conclusions: Lateral and non-skull base location, male sex, and the younger patients increase the risk for grade II and III pathology. These factors should be considered while deciding treatment choice, surgical resection, and prognosis as well.






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