Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 185  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 »   Next article
 »   Previous article
 »   Table of Contents

 Resource Links
 »   Similar in PUBMED
 »  Search Pubmed for
 »  Search in Google Scholar for
 »Related articles
 »   Citation Manager
 »   Access Statistics
 »   Reader Comments
 »   Email Alert *
 »   Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2225    
    Printed76    
    Emailed1    
    PDF Downloaded47    
    Comments [Add]    
    Cited by others 6    

Recommend this journal

 

 ORIGINAL ARTICLE
Year : 2013  |  Volume : 61  |  Issue : 3  |  Page : 293--299

The angiotensin converting enzyme insertion/deletion polymorphism and intracranial aneurysm: A meta-analysis of case-control studies


1 Department of Burn and Plastic Surgery, West China Hospital, Sichuan University, Chengdu, China
2 Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China

Correspondence Address:
Chao You
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu - 610041, Sichuan
China
Login to access the Email id

Source of Support: The Youth Project No. 30801185 (to Y.L.) and the General Program No.30872673 (to C.Y.) from the National Natural Science Foundation of China, Conflict of Interest: None


DOI: 10.4103/0028-3886.115071

Rights and Permissions

Context: Previous studies investigating the association between angiotensin converting enzyme (ACE) insertion (I)/deletion (D) polymorphism and intracranial aneurysm (IA) have provided inconsistent results and no large systematic review or meta-analyses have been conducted regarding this issue. Aim: To confirm whether the ACE I/D polymorphism correlates with risk of IA. Settings and Design: We conducted a meta-analysis to increase the statistical power by using all the available published data. Materials and Methods: Two investigators independently searched the PubMed, Medline, Embase, China National Knowledge Infrastructure and Chinese Biomedicine Databases for studies published before December 2012. For included studies, we performed meta-analyses using the Cochrane RevMan software. Statistical Analysis: Summary odds ratios (ORs) and 95% confidence intervals (CIs) for ACE I/D polymorphisms and IA were calculated in a fixed-effects model or a random-effects model when appropriate. We used Cochran's Q statistic and the I 2 statistic to assess heterogeneity and funnel plot to assess potential publication bias. We also carried out stratified analyses and sensitivity analyses by ethnicity, country and source of control group, sample size and Hardy-Weinberg equilibrium (HWE) in controls. Results: Six eligible studies were reviewed and analyzed, involving 854 cases and 1280 controls. Overall, compared with D allele, there was a close relationship between I allele and IA risk (OR: 1.21, 95% CI: 1.07-1.37, P = 0.003; Pheterogeneity = 0.56; I² = 0%). ACE I+ (I/I and I/D) genotype had significantly increased risk for IA (OR: 1.27, 95% CI: 1.03-1.57, P = 0.03; Pheterogeneity = 0.14; I² = 40%). This association remained consistently strong when analyses were limited to studies, in which genotype frequencies were in HWE. No publication bias was found in the present study. Conclusions: Our meta-analysis suggests, there is a close relationship between ACE I/D polymorphism and IA risk. Since limited studies and subjects were included, it is critical that larger and especially well-designed multicentric studies, which based on interactions of ACE and different confounding factors should be performed to re-evaluate the association.






[FULL TEXT] [PDF]*


        
Print this article     Email this article

Online since 20th March '04
Published by Wolters Kluwer - Medknow