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 »  How to Make the ...
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 » D Dimer
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REVIEW ARTICLE
Year : 2015  |  Volume : 63  |  Issue : 3  |  Page : 318-328

Cerebral venous thrombosis: An Indian perspective


1 Department of Neurology, All India Institute of Medical Sciences, New Delhi, India
2 Department of Neuroradiology, All India Institute of Medical Sciences, New Delhi, India

Date of Web Publication5-Jun-2015

Correspondence Address:
Kameshwar Prasad
Department of Neurology, Room No. 704, Neurosciences Centre, All India Institute of Medical Sciences, New Delhi - 110 029
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.158191

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 » Abstract 

Cerebral venous thrombosis (CVT) is an uncommon cause of stroke with extremely varied clinical presentations, predisposing factors, imaging findings, and outcomes, and thus can be extremely challenging to diagnose. Accurate and prompt diagnosis of CVT is crucial because timely and appropriate therapy can reverse the disease process and significantly reduce the risk of acute complications and long-term squel. In this article, we have reviewed the epidemiology, causative factors, clinical features, diagnosis and treatment of CVT from an Indian perspective. Over the last decade, a change in trends in the causative factors has been noted from India.


Keywords: Anticoagulation; causes; cerebral venous thrombosis; India; neuroimaging


How to cite this article:
Dash D, Prasad K, Joseph L. Cerebral venous thrombosis: An Indian perspective. Neurol India 2015;63:318-28

How to cite this URL:
Dash D, Prasad K, Joseph L. Cerebral venous thrombosis: An Indian perspective. Neurol India [serial online] 2015 [cited 2019 Apr 24];63:318-28. Available from: http://www.neurologyindia.com/text.asp?2015/63/3/318/158191



 » Introduction Top


Cerebral venous thrombosis (CVT) is an uncommon cause of stroke with extremely varied clinical presentations, predisposing factors, imaging findings, and outcomes. The first description of CVT, appearing in the French literature in 1825, was by Ribes, in a 45-year old man who died after a 6-month history of severe headache, epilepsy, and delirium. [1] In 1957, Padmavati et al., for the first time from India, reported 15 cases of CVT in puerperium in an epidemiological study evaluating the causes of hemiplegia in 44 women. [2] It was at that time recognized as a diagnosis which was mostly made at autopsy and considered lethal. With the advent of newer and more sophisticated imaging techniques and increasing awareness of this entity, the incidence of this disease has increased and the prognosis has improved as compared to the older series. Accurate and prompt diagnosis of CVT is crucial because timely and appropriate therapy can reverse the disease process and significantly reduce the risk of acute complications and long-term squel. The objective of this review was to assess the demographic profile, frequency of different clinical features, risk factors, and prognostic outcome in patients suffering from CVT from India.

We conducted a literature search on the Medline database to identify the published studies from India that evaluated the demographic profile, clinical features, risk factor profile, and prognostic outcome of patients with CVT. The following keywords were used: Cerebral vein thrombosis, India, CVT, intracranial embolism or thrombosis, cerebral veins, intracranial thrombosis, sinus thrombosis intracranial.


 » What is the Magnitude of the Problem in India? Top


The literature search yielded no population-based study from India exploring the exact incidence of the disease. Most of the studies published from India are hospital-based studies. In the late 1970's, hospital-based series from Northern India documented CVT in a frequency of 4.5/1000 obstetric admissions. [3] Another population-based study from Southern India in the late 1960's found that 25% of stroke patients were less than (<) 40 years of age and were primarily young women having a CVT that had occurred in the postpartum stage. [4] Banerjee et al., in an autopsy series in late 1980's found that CVT accounted for almost 10% of all strokes in India. [5] In a hospital-based study from South India in the 1980's, 15% of strokes were in individuals <40 years of age and CVT accounted for 15-20% of these cases. In a prospective hospital-based study, Panagariya and Maru evaluated 64 cases of CVT in pregnancy and puerperium. [6] In this study, approximately 50% of young patients hospitalized with a stroke had CVT as the etiological factor. However, the study suffers from an obvious referral bias. An angiographically proven study reported that 50% of the total cases of stroke in young women were related to pregnancy and puerperium and 95% of them were due to CVT. [3]

It has been thought that the incidence of CVT may be more in India compared to the western countries. This was probably due to the reporting of many large series of puerperal CVT from India in the 70's and 80's. [7] But, due to the lack of any population-based study or nationwide multicentric hospital-based studies, the exact incidence of CVT in India is still not known. There have been a few epidemiological studies from the western countries trying to determine the incidence of CVT. In a nationwide hospital-based series in Portugal, an incidence of 0.22/100,000/year has been reported. [8] A well-designed cross-sectional epidemiological study performed in the Netherlands had shown an incidence of 1.32/100,000/year. [9]


 » Demographic Profile Top


The mean age of patients in the large studies published from India ranged from 31.3 to 48.7 years. In the largest hospital-based prospective cohort study from India (Nizam's Institute Venous Stroke Registry [NIVSR]) by Narayan et al., 428 consecutive patients with CVT were enrolled over a period of 8 years from a tertiary care hospital from South India, the mean age of the patients in this study being 31.3 years. [10]

Most of the earlier case series from India reported a higher proportion of women suffering from CVT than men, except a series of 110 angiographically proven CVT by Parikh et al., which had a male dominance. [11] A large hospital-based case series of 317 patients with CVT recruited over a period of 8΍ years during the 80's had only 15 male patients. [12] This gender bias was usually attributed to gender-specific risk factors like the usage of oral contraceptives (OCs) and the influence of other factors such as pregnancy, puerperium, and hormone replacement therapy. In contrast to this, the recent case series from India do not show this trend of female dominance. In their study of 428 patients of CVT recruited from a tertiary care hospital of Hyderabad, Narayan et al., had a larger proportion of males than females. [10] Showing a similar trend, a large prospective study which recruited 612 consecutive patients of CVT from various hospitals of Mumbai had a male to female ratio of 3:2. [13] The plausible reason for this change in gender trends over the last two decades could be the improvement in obstetric care.


 » What are the Etiological Factors for Cerebral Venous Thrombosis? Top


More than 100 putative causes of CVT have been described in the literature. The risk factors for venous thrombosis, in general, are linked classically to the Virchow triad of stasis of the blood, changes in the vessel wall, and changes in the composition of blood. Etiological factors are usually divided into acquired risks (e.g. surgery, trauma, pregnancy, puerperium, antiphospholipid syndrome, cancer, exogenous hormones) and genetic risks (inherited thrombophilia). Drugs like oral contraceptives (OCs), steroids, hormone replacement therapy, and oncological treatments have been implicated in the causation of CVT. [Table 1] lists the various etiological factors responsible for CVT.
Table 1: Causes of cerebral venous thrombosis

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Puerperium and pregnancy, as predisposing factors for CVT, are well known. Most of the pregnancy-related CVT occurs in the third trimester or puerperium. During pregnancy and for 6-8 weeks after birth, women are at increased risk of developing venous thromboembolic (VTE) events. Pregnancy induces several prothrombotic changes in the coagulation system that persists at least during early puerperium. Hypercoagulability worsens after delivery as a result of volume depletion and trauma. Most of the earlier case series of CVT reported from India have very high proportions of puerperal CVT. In 1984, Srinivasan, reported 135 cases of stroke in women, of whom only 6 had an arterial stroke, and the rest had a CVT. [14]

In the recent times, a change in this trend has been noted. The NIVSR cohort study and the study by Pai et al., have reported only 9.8% and 8% patients in the postpartum or pregnant state, respectively., [10],[13] This percentage is much lower than reported in prior studies. The improvement in obstetric care could be the possible cause for this change.

There is ample evidence to suggest a causal relationship between oral contraceptives (OCPs) and CVT. In a meta-analysis of 17 studies, summary odds ratio for developing cerebral venous sinus thrombosis (CVST) was 5.59 in women using OCPs compared with controls. [15] It is clear from this study that the use of OCs is associated with an increased risk of CVT, that the great majority of younger, non pregnant women with CVT are OC users, and that the risk of CVT with OC use in women is greater among those with a hereditary prothrombotic factor. In developed countries, OC as a risk factor for CVT has been more commonly reported compared to the developing countries. In the prospective International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) cohort of 624 adults with CVT, 46% of women who developed CVT were on OC's, which made it the third most important risk factor; whereas, in a study by Khealani et al., of 109 patients of CVT from Pakistan and the middle east, only 14% of women were using OCs. [16],[17] The NIVSR study cohort also reported that only 11.4% patients had usage of OCs. [10] All the large series from India have shown a much lower proportion of OC usage as a risk factor for CVT compared to the series from west. [8],[10],[13],[16],[18] This could be due to the different sociocultural milieu of our patients compared to the western countries.

The most common risk factor identified for CVT throughout the world is often a prothrombotic condition. In the ISCVT cohort, a prothrombotic condition was found in 34% of all patients, and a genetic prothrombotic condition was found in 22% of all patients. [16] Almost all the large series from the western literature have a large proportion of patients having a prothrombotic condition as a risk factor. Most of the earlier published studies from India did not have information regarding these inherited prothrombotic states due to lack of laboratory facilities and resources to conduct these tests. But in recent times, Pai et al. recruited 612 consecutive patients from various hospitals of Bombay over a period of 9 years and tested them for the common thrombophilia markers (protein C [PC], protein S, antithrombin REVIEW ARTICLE, and factor V Leiden [FVL] mutation). [13] 18% of the patients were positive for the thrombophilia markers studied. PC deficiency was the most common thrombophilia marker followed by a deficiency of protein S, FVL mutation, and AT deficiency. This study had a similar proportion of patients with a genetic prothrombotic state when compared to that reported from developed countries. Similarly, Narayan et al., also reported 12.3% patients having a genetic prothrombotic condition as a risk factor for CVT. [10] The proportion of CVT patients with a prothrombotic condition in India is also similar to that of Western countries and has been probably under-reported in the earlier studies (due to lack of laboratory facilities).

Although infective causes of CVT were frequently reported in the earlier series, they account for a very small percentage of patients in the recent studies. [13],[10] This could be due to the availability of potent broad spectrum antibiotics in today's era.

Although there is a high prevalence of tuberculosis in India, the association of tubercular meningitis (TBM) with CVT has rarely been reported. Literature search on Medline with the key words of "CVT and tuberculosis" yielded only a few case reports. [19],[20],[21] Pai et al. reported associated tuberculosis as an etiological factor for CVT in 14.3% of patients. [13] But the authors have not commented about the type of tuberculosis (whether it was TBM or pulmonary tuberculosis). The postulated mechanisms of CVT in tuberculosis are: Endothelial injury due to the inflammatory response, sluggish venous flow, increased platelet aggregation and release of procoagulant factors. [21] Due to the lack of larger studies, it is difficult to establish if the co-occurrence of these two diseases is due to a chance association or it is causally related. If a patient has clinical features and signs suggestive of chronic meningitis along with the cerebrospinal fluid examination and neuroimaging findings suggesting the presence of TBM; or, if there is evidence of tuberculosis elsewhere, then the suspicion of concomitant TBM should arise in the clinician's mind. Similarly, in a patient of diagnosed TBM, worsening of a preexisting headache, and an impairment of consciousness with the presence of seizures should raise the suspicion of CVT, that can be confirmed on imaging.

When we compare the etiological factors of CVT in the western series with the recently published Indian series, there are a similar proportion of patients with prothrombotic conditions and pregnancy and puerperium in both [Table 2] and [Table 3]. But, the usage of OC's is still found much less commonly in the Indian literature compared to Western studies.
Table 2: Clinical features and etiological factors of patients with CVT (Indian studies)

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Table 3: Clinical features and etiological factors in patients with CVT (studies from Western countries)

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Despite the continuous description of new causes, in about 13% of patients, no etiology can be found, as has been seen in the recent series. [16] Therefore, the search for an etiology remains a difficult problem in CVT. It requires an extensive initial workup and when no cause is found, a long term follow-up with repeated investigations.

Cerebral venous thrombosis is multifactorial, and identification of one risk factor should not deter the clinician from searching for more causes. Narayan et al. reported 18.2% patients having multiple risk factors in their study from South India. [10]


 » Clinical Presentation Top


In contrast to the arterial stroke, which can be easily diagnosed clinically in a majority of the cases, CVT has no single pattern of presentation, and it may be difficult to diagnose it on clinical grounds alone. Clinical findings in CVT fall into two major categories: Those related to increased intracranial pressure due to impaired venous drainage; and, those related to focal brain injury from venous ischemia/infarction or hemorrhage.

Headache is the most frequent and most of the times, the earliest symptom of CVT. In the NIVSR cohort, 88.3% patients had headache as the presenting complaint with CVT. [16] Headache may be acute, sub-acute, chronic or may even have a thunderclap-like presentation. In most of the cases, headache precedes the development of all other features by days, weeks and sometimes even months. The mechanism of headache is postulated to be the stretching of nerve fibers in the walls of the occluded sinus and local inflammation, as suggested by the evidence of contrast enhancement of the sinus wall surrounding the clot.

Except for the olfactory nerve, all other cranial nerves have been described to be involved. Sometimes, isolated VII or VIII cranial nerve palsy is seen with transverse/sigmoid sinus involvement. If the thrombosis extends to the jugular vein, the patient may develop involvement of cranial nerves IX, X, XI, and XII (jugular foramen syndrome). Cavernous sinus thrombosis may lead to III, IV, and VI cranial nerve palsies. Pai et al. reported 7.3% of patients having cranial nerve palsies in their hospital based study. [13]

Seizures are far more frequently seen in CVT than in arterial stroke with a frequency of 35-50% of all patients suffering from it, with an even higher incidence in peripartum CVT (76%). [8] Kalita et al. conducted a retrospective study to evaluate the frequency and predicting factors responsible for seizures as the predominant presentation in patients with CVT. Of the 90 patients, 42 patients presented with seizures, of whom 10 had status epilepticus. On multivariate analysis, only the presence of a supratentorial parenchymal lesion on magnetic resonance imaging (MRI) was independently associated with a higher risk of presenting seizures. [22]

The mental status may be quite variable, with patients showing no change in alertness, developing mild confusion or progressing to coma. Earlier case series from India reported that 43% to 93% of patients had an altered sensorium at presentation., [3],[23],[24] Recent studies show a lower proportion of patients having changes in sensorium at presentation. [10] The reason for this decrease is probably due to patients seeking medical help earlier in the recent times.

Focal neurological deficit may occur depending on the area involved. Thus, hemiparesis may be encountered, and in some cases of sagittal sinus thrombosis, there is involvement of bilateral lower extremities. Papilledema may be seen on fundoscopy in chronic cases or those with a delayed presentation but is less common in acute cases. [Table 2] depicts the distribution of different clinical features in the different series from India.

In the NIVSR cohort, a stroke-like presentation was present in 28.5% patients, isolated seizures in 29.4%, benign intracranial hypertension-like presentation in 18.2%, encephalopathy in 25.2%, and psychosis was observed in 1.8% patients. [10] In a cohort of 131 patients who presented with papilledema and were clinically suspected to be having idiopathic intracranial hypertension, 10% patients were confirmed to be having a CVT when magnetic resonance imaging (MRI)/magnetic resonance venography (MRV) was performed. [25] There is almost similar kind of distribution of clinical features from the series of CVT from India and western countries [Table 2] and [Table 3].


 » How to Make the Diagnosis of Cerebral Venous Thrombosis? Top


The diagnosis of CVT is based on a high degree of clinical suspicion followed by imaging confirmation. The imaging findings of CVT can be categorized as direct, as when there is a visualization of cortical or dural sinus thrombus; or, indirect, as when there are ischemic changes related to the venous outflow disturbance.

Cranial computed tomography (CT) is usually the first, and in countries like ours, the only investigation performed in the emergency department.

In about one-third of cases, the CT demonstrates direct signs of CVT, which are as follows: The cord sign, usually seen on head CT with contrast, is the visualization of the hyperdense thrombosed cortical vein [Figure 1]; the dense triangle sign, seen on noncontrast head CT, is the visualization of a fresh thrombus in the posterior part of the sagittal sinus; and, the most frequent direct sign is the "empty triangle" or delta sign, seen as non-filling of the confluence of sinuses after contrast injection. In the NIVSR cohort, only 11.2% patients demonstrated an empty delta sign. [10]

More frequently, the contrast-enhanced CT scan reveals indirect signs such as local or generalized brain swelling, contrast enhancement of the falx and tentorium, and localized hypodense or hyperdense areas reflecting hemorrhagic transformation. The diagnostic value of contrast CT is significantly increased by combining it with helical CT venography that has a sensitivity of 95% in depicting the venous anatomy.
Figure 1: Non-enhanced head computed tomography (CT) showing the linear hyperdense cord sign

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In a suspicious case, the diagnosis may be confirmed by more sensitive imaging techniques such as an MRI and MRV. The conventional MR sequences show patent dural sinuses as flow voids. The coronal images are best suited for visualization of the superior sagittal, transverse, and sigmoid sinuses. A plane parallel to the dural sinus offers better depiction of the extent of the thrombus within them. In the acute stage, the thrombus may be seen as iso-intense on T1W but hypointense on T2W MRI sequences. In such a situation, either a gradient sequence or an MRV is warranted, the latter being the investigation of choice.

The vascular imaging includes MRV and conventional angiography. MRV is most commonly used to confirm the diagnosis of CVT in a suspected case especially in the acute stage, as direct visualization of the thrombus may be difficult on MR (as it is isointense on T2). Contrast MRV is preferred although MRV may also be performed without the use of a contrast agent using the time-of-flight technique or the phase contrast technique. Because these techniques use MR flow phenomena for contrast generation, they are subject to flow-related image artifacts. [Figure 2] depicts a case of superior sagittal sinus thrombosis.
Figure 2: A 35y old lady presented with headache and seizures; (a, b and c) T2 Flair images with a subcortical hyperintense signal in the right middle frontal region and a hyperintense thrombus (arrow) in the superior sagittal sinus suggestive of superior sagittal sinus thrombosis and venous infarct in the right frontal area. (d) MRV shows irregular filing defect in the superior sagittal sinus

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A 64-slice multi-detector row CT and CT venogram have been used in some centers for the diagnosis of venous sinus thrombosis and has been found to be 100% sensitive and specific. Cerebral catheter angiography is rarely used for the diagnosis of CVT because of the invasive nature of this diagnostic modality; although conventional angiography best demonstrates the dynamics of the intracranial circulation. The venous collateral circulation is also best appreciated on the conventional angiography. Dilated tortuous collateral veins develop in the setting of chronic venous hypertension related to the veno-occlusive disease. This constellation of findings on the venous phase of the angiogram has been referred to as the "pseudophlebitic pattern." The ability to develop venous collateral circulation accounts for the variable clinical presentations and the unpredictable outcome of CVT.

According to the Indian guidelines for stroke management, patients suspected to be having a stroke due to CVT should be investigated by MRI/MRV/CTV only if the CVT is not diagnosed by a CT scan. [26] In a statement issued by the American Heart Association/American Stroke Association in 2011, a negative plain CT or MRI does not rule out the presence of a CVT. They recommend a venographic study (either CTV or MRV) in suspected CVT if the plain CT or MRI is negative. The venography was also recommended in order to define the extent of CVT if the plain CT or MRI suggests the presence of a CVT (Class I; Level of Evidence C). [27]


 » Laboratory Tests Top


There is no confirmatory laboratory test that can confidently rule out CVT in the acute phase of the disease. Routine blood studies consisting of a complete blood count, chemistry panel, prothrombin time, and activated partial thromboplastin time (PTT) are recommended for patients with suspected CVT. The results from these tests may suggest the presence of conditions that contribute to the development of CVT such as an underlying hypercoagulable state, an infection, or an inflammatory process. Screening for potential prothrombotic conditions that may predispose to CVT is recommended.


 » D Dimer Top


Misra et al. conducted a study on 26 patients with CVT proven by MRV and evaluated the sensitivity and specificity of D-dimer in the diagnosis of CVT. The sensitivity and specificity of D-dimer in the diagnosis of CVST were 77% each, respectively. [28]

A meta-analysis including 14 studies that evaluated D-dimer in 1134 patients for the diagnosis of suspected or confirmed CVT was conducted by Dentali et al. The D-dimer accuracy was good, with a resulting weighted mean sensitivity of 93.9% (95% confidence interval [CI] - 87.5-97.1) and weighted mean specificity of 89.7% (95% CI - 86.5-92.2), calculated with a bivariate approach. The potential risk factors for false-negative D-dimer results included isolated headache, longer duration of symptoms, and limited sinus involvement. [29]

The D-dimer measurement is a diagnostic screening tool for the assessment of patients with possible CVT. However, a normal D-dimer value cannot exclude the presence of CVT, especially in patients with isolated headache or with thrombosis of a single sinus.


 » Treatment Top


Anticoagulation

The immediate goals of anticoagulant (AC) therapy are to recanalize the occluded sinus, prevent propagation of the thrombus and to treat the underlying prothrombotic state. Heparin is the obvious therapy for any venous thrombosis yet AC therapy has been controversial, due to the high incidence of spontaneous hemorrhagic infarcts in patients with CVT.

The first placebo-controlled trial of intravenous (IV) heparin by Einhδupl et al. was stopped after 20 patients were enrolled because the investigators found a statistically significant beneficial effect. [30] The second randomized trial by De Bruijn et al. compared body weight adjusted subcutaneous low molecular weight heparin (LMWH) with placebo in 60 patients with CVST. [31] A poor outcome - defined as death or Barthel index <15 - was observed after 3 weeks in six of the 30 patients treated with LMWH (20%) compared with seven of the 29 controls (24%). After 3 months, 3 patients (10%) in the LMWH group and 6 patients (21%) in the placebo group had a poor outcome that corresponded to a non-significant absolute risk reduction of 11% in favor of the active treatment. No new intracerebral hemorrhage (ICH) or secondary worsening of the 15 patients with pretreatment hemorrhage was observed in the LMWH group.

A cochrane meta-analysis of these 2 trials revealed a non-statistically significant relative risk of death or dependency with AC (relative risk 0.46, 95% CI - 0.16-1.31), with a risk difference in favor of AC of − 13% (95% CI − 30% to 3%). The relative risk of death was 0.33 (95% CI - 0.08-1.21), with a risk difference of − 13% (95% CI − 27% to 1%). Thus, a relative risk reduction of 54% in mortality and severe disability was demonstrated with heparin treatment. Although this difference did not reach statistical significance, both trials showed a consistent and clinically meaningful trend in favor of AC and demonstrated the safety of AC therapy. [32]

Nagaraja et al. prospectively randomized 57 women with puerperal CVT from South India into a treatment group and a placebo group. Twenty-nine patients received IV unfractionated heparin (UFH), 5000 IU every 6 h, and then dose-adjusted to reach a PTT of 1.5 times the initial value, and 28 subjects were in the control group. Two patients in the control group died, and one had a residual paresis at 6 months. In the heparin group, all patients recovered. The study had methodological pitfalls as the diagnosis was based on CT findings only, and the outcome assessment was non-blinded. [33]

In an open-label trial by Nagaraja et al. on 150 patients with CVT, 73 received low-dose heparin (2500 thrice daily) and 77 did not receive heparin. There was a reduction of death (8 vs. 18; P < 0.001) and increase in complete recovery (34 vs. 14; P < 0.001) in the group which received heparin compared to that which did not receive heparin. [34]

There is no consensus on the modalities of treatment with heparin. Some recommend the use of LMWH because of the better pharmacokinetics and the lower risk of thrombocytopenia.

In an open-label randomized control trial design study conducted by Misra et al., 32 patients were randomized to the UFH arm and 34 to the LMWH arm. The hospital mortality and 3 months functional score in the form of Barthel index score were the outcome measures. In-hospital mortality was significantly lower in the LMWH group (0% vs. 19%). At 3 months, the proportion of patients with complete recovery was greater for the LMWH group (88% vs. 63%), but the difference was not statistically significant. [35] The limitations of this study are the small numbers and non-blinded assessment. In another retrospective review of 64 patients with CVT by Pillai et al., LMWH was found to be having a good safety profile. [36]

Guidelines from India, Europe and America recommend that patients with CVT without contraindications for AC should be treated either with activated partial thromboplastin time adjusted IV heparin or body-weight-adjusted LMWH. [26],[27],[37] The presence of concomitant intra-cranial hemorrhage related to CVT is not a contraindication for heparin therapy. The optimal duration of heparin is not established. As for deep vein thrombosis of the leg, after a few days of heparin, once the patient is stabilized, oral ACs are started to reduce the risk of heparin-induced thrombocytopenia. Warfarin is usually adjusted to obtain an International Normalized Ratio between 2 and 3. The usually recommended duration of treatment is 3-6 months, particularly when there is a known acute cause for CVT, such as minor head trauma, postpartum state, or local infection. In contrast, prolonged treatment is warranted whenever there is a continuing risk of thrombosis, such as lengthy immobilization, malignant disease, inflammatory disease such as systemic lupus erythematosus or Behcet's disease, inherited thrombophilia or recurrent venous thrombosis.


 » Interventional/Surgical Considerations Top


Endovascular thrombolysis

If the clinical status of the patient worsens despite adequate AC and symptomatic treatment, then a direct endovascular thrombolysis has been used as an alternative treatment. The aim of direct thrombolysis is to dissolve the venous clot by delivering a thrombolytic substance within the occluded sinus through an IV catheter. The use of direct intrasinus thrombolytic techniques and mechanical therapies is only supported by case reports and small case series. No randomized controlled trials have evaluated systemic or local thrombolysis for the treatment of CVT. A systematic review of 169 patients treated with local thrombolysis reported that only 5% of patients died during the acute phase of CVT and 8% were dependent at discharge, suggesting a possible benefit for patients with severe CVT. [38]

In a prospective observational study by Kumar et al., 19 patients received intrasinus thrombolytic therapy in whom clinical deterioration continued in the form of rapid worsening of consciousness or aggravation of neurological deficits despite adequate AC. [39] At discharge, 79% patients had a good outcome and were either asymptomatic or had only mild deficits and were independent for activities of daily living. 3 patients died, and one survived with severe neurological deficits. At a median follow-up of 6.3 months, 14 (74%) patients had no or mild neurological deficits.

Garge et al. in a recently published prospective observational study evaluating the effect of endovascular thrombolysis in 10 patients with CVT, reported a good functional outcome in the form of modified Rankin Scale (mRS) score of 1 in six patients with dural sinus occlusion with restricted venous outflow at a 1-month follow-up. [40]

The role of mechanical fragmentation of the clot with or without thrombolytic agent in patients with CVT is limited. Haghighi et al., in a systematic review to evaluate the role of mechanical thrombectomy, reported that 62.5% patients had no or minor disability, 10.9% had a major disability, and 16.1% died after such procedures. [41]

In a recent editorial by Murthy, it was concluded that endovascular therapy should be a treatment option in patients who have neurological deterioration in spite of adequate supportive treatment and optimal AC, with no evidence of ICH, elevated intracranial pressure, or brain herniation. Mechanical thrombectomy may be the preferred option in patients with ICH. The role of endovascular therapy will be clear only after a well-designed randomized control study is conducted in the future. [42]

Decompressive hemicraniectomy and hematoma evacuation

The leading cause of death is the hemorrhagic conversion of large venous infarcts resulting in brain herniation. In these situations, emergency decompressive hemicraniectomy can prevent death. A retrospective registry of cases of acute CVT treated with decompressive surgery (craniectomy or hematoma evacuation) in 22 centers and a systematic review of all published cases of CVT treated with decompressive surgery was conducted by Ferro et al.[43] Of the sixty-nine patients, decompressive craniectomy was performed in 45 patients, hematoma evacuation was performed in 7, and both interventions were performed in 17 patients. At the last follow-up, 17.4% patients had an unfavorable outcome. 37.7% patients had an mRS score 0-1, 56.5% had an mRS score 0-2, 5.8% were alive with the mRS score being 4-5, and 15.9% patients died. The authors concluded that in patients with CVT with a large parenchymal lesion causing herniation, decompressive surgery was life-saving and often resulted in a good functional outcome, even in patients with severe clinical manifestations.

In a retrospective chart review by Aaron et al., 44 out of 587 (7.4%) patients with CVT admitted to a tertiary care center of South India underwent decompressive hemicraniectomy. A high proportion of survivors had an mRS of ≤2 by 6 months of follow-up. Predictors of increased survival were age <40 years and surgery within 12 h. [44]

Based on the current available literature, decompressive hemicraniectomy may be needed as a life-saving measure if a large venous infarction leads to a significant increase in intracranial pressure. Similarly, large hematomas rarely may need to be considered for surgical evacuation if associated with a progressive and severe neurological deficit. [27]


 » Cerebral Venous Thrombosis and Pregnancy Top


Pregnancy induces several prothrombotic changes in the coagulation system that persists at least during early puerperium. Hypercoagulability worsens after delivery as a result of volume depletion and trauma. The greatest risk period for the occurrence of CVT is in the third trimester and the first 4 postpartum weeks. [45] CVT during the first trimester is rare, and there are only few case reports of such occurrences in the literature. [46],[47] In patients who have had an occurrence of CVT in the prior pregnancy, the risk of recurrence in the future pregnancy is low. Dentali et al. in a systematic review estimated the occurrence of one episode of CVT among 103 reported pregnancies in women with a previous history of CVT (0.97%, range 0-2.9%). [48] On the basis of the available evidence, CVT is not a contraindication for future pregnancies. Unfortunately, there are no reliable data about antithrombotic prophylaxis during subsequent pregnancies in women who have previously suffered an episode of CVT. Patients who have had CVT and also possess a transient risk factor are advised to use LMWH prophylaxis during the postpartum period only (4-6 weeks). In patients who have a history of recurrent CVT, venous thromboembolism after CVT, or the first CVT with severe thrombophilia (i.e. homozygous prothrombin G20210A; homozygous factor V Leiden thrombophilia; deficiencies of protein C, protein S, or antithrombin; combined thrombophilia defects; or antiphospholipid syndrome) long-term ACs have to be given. If these patients conceive, then they cannot be given vitamin K antagonists (e.g. warfarin) as it is associated with fetal dysgenesis and bleeding in the fetus and neonate. The choice of AC during pregnancy would be low molecular weight heparin over unfractionated heparin, as it is not associated with teratogenicity or increased risk of fetal bleeding.


 » Prognosis Top


In earlier studies, CVT was diagnosed mainly at autopsy and was considered to be lethal, with the mortality figures ranging from 30% to 50%. With the advent of newer imaging modalities and increased sensitization towards diagnosing CVT, the mortality rates have decreased. The main cause of death is either transtentorial herniation due to a massive hemorrhagic infarction or due to an associated complication like sepsis, uncontrolled seizures, or pulmonary embolism.

Pai et al., reported an in-hospital mortality of 12.9% in their cohort of 612 patients. [13] In the NIVSR cohort, the in-hospital mortality was noted in 7.7% patients, and the cause of death was raised intracranial pressure and also underlying complications like septicemia. At a 3 month follow-up, 52.8% patients had an mRS of 0-1, 10.9% of them became functionally independent, and 25.7% remained dependent. The presence of fever, deep venous thrombosis, seizures, focal neurological deficits, and unconsciousness were predictors of a poor outcome. [10]

 
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    Figures

  [Figure 1], [Figure 2]
 
 
    Tables

  [Table 1], [Table 2], [Table 3]

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