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Year : 2015  |  Volume : 63  |  Issue : 3  |  Page : 353--359

Adverse effects of antiepileptic drugs and quality of life in pediatric epilepsy

1 Department of Pediatrics, Al Adan Hospital, Hadiya, Kuwait, Serbia
2 Department of Pediatrics, Al Sabah Hospital, Kuwait, Serbia
3 Clinic for Neurology and Psychiatry for Children and Youth, Belgrade, Serbia

Correspondence Address:
Dejan Stevanovic
Clinic for Neurology and Psychiatry for Children and Youth, Dr. Subotic 6a, 11000 Belgrade
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.158203

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Background: In pediatric epilepsy, health-related quality of life (HRQOL) may be affected across the physical, psychological, social, and school domains. Studies have shown that antiepileptic drugs (AEDs) could have a significant negative impact on HRQOL, but these findings are scarce and inconsistent. Aim : To evaluate the influence that the adverse effects of AEDs have on HRQOL in pediatric epilepsy. Materials and Methods: A total of 75 children with epilepsy and at least one parent participated in this study. The Pediatric Quality of Life Inventory (PedsQL) was utilized to assess the HRQOL, while the Adverse Event Profile (AEP) was used to assess the presence and severity of the adverse effects of AEDs. Results: Assessing the children's ratings, the AEP score significantly influenced the PedsQL based psychosocial functioning score (P < 0.02; partial ç2 = 0.07); and, assessing the parents' ratings, the AEP score significantly influenced both the PedsQL based physical functioning score (P < 0.02; partial ç2 = 0.07) as well as the PedsQL psychosocial functioning score (P < 0.001, partial ç2 = 0.30). Conclusion: The frequency and severity of AED-related adverse effects could significantly predict the lowered levels of HRQOL among children with epilepsy, in particular having a large impact on their psychosocial functioning.


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Online since 20th March '04
Published by Wolters Kluwer - Medknow