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 NI FEATURE: THE QUEST - REVIEW ARTICLE
Year : 2015  |  Volume : 63  |  Issue : 4  |  Page : 583--588

Neurorestorative strategies for Alzheimer's disease


1 Department of Clinical Medicine, Medical Center, Tsinghua University, Haidian District, Beijing 100084, China
2 Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China
3 Department of Neurosurgery, Tsinghua University Yuquan Hospital, Shijingshan District, Beijing 100049, China

Correspondence Address:
Heling Chu
Department of Neurology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, No. 12, Mid. Wulumuqi Road, Shanghai 200040
China
Huancong Zuo
Tsinghua University Yuquan Hospital, No. 5, Shijingshan Road, Shijingshan District, Beijing 100049
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.162057

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Alzheimer's disease (AD) is characterized by beta-amyloid plaques and neurofibrillary tangles that cause devastating cognitive and memory deficits. AD is known to be associated with neuronal death and synaptic loss. Thus, methods to retard the progression of the disease and to promote neuro-regeneration are vital for the prevention of advancement of AD. The recent trend is to decipher the molecular mechanisms of AD, and further aim at neuro-restorative mechanisms such as neuro-protection, neuro-modulation, and neuro-regeneration. In this review, we provide an overview of the recent studies describing various neuro-restorative strategies for AD and mainly focus on stem cell and neuro-modulation therapies. Furthermore, we briefly refer to the other neurorestorative treatments including medications, bioengineering, and gene therapies for AD. Although most of them remain in an experimental phase, neuro-restorative strategies may have the potential for clinical use in the management of this debilitative disease.






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Online since 20th March '04
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