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 CASE REPORT
Year : 2015  |  Volume : 63  |  Issue : 6  |  Page : 915--917

Neurocognitive impairment in Susac syndrome: Magnetic resonance imaging and Tc-99m hexamethylpropyleneamine oxime single photon emission computed tomography correlation


Department of Medical Imaging, The Townsville Hospital, Douglas, Queensland, Australia

Correspondence Address:
Dalveer Singh
Department of Medical Imaging, The Townsville Hospital, Douglas, Queensland 4102
Australia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.170076

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Susac syndrome is a clinical triad of branch retinal artery occlusions, sensorineural hearing loss, and encephalopathy. The characteristic central corpus callosum involvement in Susac syndrome is readily recognizable on conventional magnetic resonance imaging (MRI); however, the neurocognitive effect of these lesions is not well-understood. We present a case of Susac syndrome with typical MRI findings of central callosal lesions at diagnosis. The patient had a protracted clinical course and did not respond well to immunosuppression therapy. Follow-up brain single photon emission computed tomography with Tc-99m hexamethylpropyleneamine oxime revealed marked unilateral frontoparietal and temporal lobe hypoperfusion. Our case highlights the utility of functional neuroimaging to uncover the possible underlying white matter dysfunction, which is not otherwise detectable with conventional MRI techniques.






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Online since 20th March '04
Published by Wolters Kluwer - Medknow