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ORIGINAL ARTICLE
Year : 2016  |  Volume : 64  |  Issue : 1  |  Page : 75-80

Endoscopic third ventriculostomy through lamina terminalis: A feasible alternative to standard endoscopic third ventriculostomy


Department of Neurosurgery, Kamineni Hospitals, Hyderabad, Telangana, India

Date of Web Publication11-Jan-2016

Correspondence Address:
Subodh Raju
OPD No: 10, Department of Neurosurgery, Kamineni Hospitals, LB Nagar, Hyderabad, Telangana
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.173655

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 » Abstract 

Context: Endoscopic third ventriculostomy (ETV), wherein a stoma is created in the floor of the third ventricle, has now become the standard procedure for noncommunicating hydrocephalus across the world. However, in certain situations, this procedure may pose technical difficulties. These include a narrow prepontine space, vascularized third ventricular floor, the presence of prominent blood vessels traversing within the prepontine space, significant basal exudates, thickened and ill-defined third ventricular floor, and distorted floor anatomy. In such situations, an endoscopic lamina terminalis opening may provide a safer and more effective alternative to the standard technique.
Aims: The paper aims to discuss the different indications, technical nuances, and outcome of endoscopic third ventriculostomy through the lamina terminalis (ETV LT) utilizing the standard transventricular transforaminal route.
Settings and Design: A total of 240 patients underwent ETV between January 2007 and January 2014. Of these patients, 8 patients required an EVT LT and these patients formed the subset of patients for the present study. In all the 8 patients, the decision to perform fenestration of the LT during the endoscopic procedure was taken intraoperatively. We qualified a procedure to be a success when a second procedure was not required subsequently.
Results: Of the eight patients in whom ETV LT was done, four had aqueductal stenosis (including one case of post-primary ETV), three patients were diagnosed with post-meningitic hydrocephalus, and the remaining patient had a posterior fossa tumor. The procedure was successful in 6 of our patients who did not require a second procedure till the last follow-up.
Conclusions: Endoscopic transventricular transforaminal LT fenestration with a flexible neuroendoscope is a feasible alternative to the standard ETV when technical difficulties precludes safe performance of the latter procedure.


Keywords: Endoscopic third ventriculostomy; hydrocephalus; lamina terminalis fenestration; neuroendoscopy


How to cite this article:
Raju S, Ramesh S. Endoscopic third ventriculostomy through lamina terminalis: A feasible alternative to standard endoscopic third ventriculostomy. Neurol India 2016;64:75-80

How to cite this URL:
Raju S, Ramesh S. Endoscopic third ventriculostomy through lamina terminalis: A feasible alternative to standard endoscopic third ventriculostomy. Neurol India [serial online] 2016 [cited 2019 Dec 16];64:75-80. Available from: http://www.neurologyindia.com/text.asp?2016/64/1/75/173655



 » Introduction Top


Over the past 2 decades, endoscopic third ventriculostomy (ETV) has become a well established procedure of choice for obstructive hydrocephalus throughout the world.[1] Although Sir Walter Dandy began treating hydrocephalus in the early 20th century, it was Michael R. Gaab's development of the universal neuroendoscopic system, in cooperation with Karl Storz Company, in the late 1980 and early 1990 that heralded the era of neuroendoscopy. The concept of opening of the lamina terminalis (LT) via a transventricular transforaminal route with the help of a rigid neuroendoscope for the treatment of hydrocephalus is not new. Oertel et al., performed an ETV-LT using a rigid endoscope in patients where ETV could not be performed in a standard fashion. However, utilization of a rigid endoscope always carried the risk of fornicial injury during this procedure.[2] It has been observed that the safe opening of the LT via a transventricular route while preserving the anatomical structures, could be achieved with a flexible steerable endoscope via a routine precoronal burr hole.[3],[4] Endoscopic LT fenestration using a supraorbital minicraniotomy has also been described by some authors in human cadaveric specimens.[5],[6] On the other hand, open microsurgical fenestration of the LT is a widely practiced adjunct during the anterior circulation aneurysm surgery. The literature reporting the results of ETV-LT is very limited and thus very little is known about this potentially effective operative strategy. We wish to present our experience of utilizing the endoscopic transventricular transforaminal LT fenestration in a select group of patients.


 » Material and Methods Top


Study design: A retrospective observational study

This study was a retrospective analysis of the clinical data, follow-up details, and video recordings of all our patients who underwent ETV via the trans-LT approach. There were eight cases from January 2007 to January 2014 who underwent this procedure. The total number of ETVs performed in the same period at our centre was 240.

All our 8 patients had undergone previous attempts at cerebrospinal fluid (CSF) diversion using a ventriculoperitoneal (VP) shunt or a standard ETV. These prior procedures either failed to function (in case of VP shunts) or were technical failures (in case of ETV). All patients underwent a detailed clinical evaluation, a developmental assessment using the Trivandrum Developmental Scale, and computed tomography (CT) scan or magnetic resonance imaging (MRI) of the brain. All patients were prospectively followed up.

A standard (Gaab's) rigid lens neuroendoscope with all standard accessories was used for the routine ETV procedure. In addition, we used the Karl Storz flexible neuroendoscope with a 2-mm working channel and accessories such as the perforating forceps, monopolar diathermy, and grasping forceps. The 2-mm working channel allowed for passage of a 3F (Fogarty) catheter for stoma dilatation.

Brief anatomy

Anterior wall of the third ventricle extends from the foramen of Monro above to the optic chiasma below. LT, which effectively forms this anterior third ventricular wall, actually is a thin sheet of gray matter covered by pia mater/ventricular ependyma, stretching between the anterior commissure and the optic chiasma. When viewed from within, the structures forming the anterior wall of the third ventricle are (from above downwards) rostrum of the corpus callosum, anterior commissure, LT, optic nerve, and chiasma. The A1-anterior communicating artery (ACommA) complex with various perforating vessels are intimately related to this wall lying within the cisterna lamina terminalis. The ideal stoma is created within the LT by communicating the third ventricle with the suprachiasmatic region.

Endoscopic anatomy

The initial step during endoscopy includes identification of the floor of the third ventricle including the mammillary bodies and the infundibulum with its recess [Figure 1]a. We bent the tip of the flexible neuroendoscope anteriorly, and the following structures were identified: Optic chiasma and LT [Figure 1]b. The LT is seen as a thin, transparent, triangular sheet of gray matter between the anterior commissure and the optic chiasma.
Figure 1:(a) Endoscopic view of the third ventricular floor through the foramen of Monro. (b) Lamina terminalis extending anterosuperiorly from the optic chiasm

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Surgical procedure

In all these cases, the decision to open up the LT was taken intraoperatively when some difficulty in perforating the floor of the third ventricle was encountered.

All procedures were performed under general anesthesia in supine position with the patient's head being stabilized by either a jelly head ring or a horseshoe. Preoperative antibiotics were administered as per protocol. A standard precoronal burr hole, 1cm anterior to the coronal suture and 2 cm away from the midline (Kocher's point), was performed. The dura was incised and a working sheath with the obturator was introduced into the lateral ventricle. CSF was collected for routine analysis in all cases. Initially, third ventriculostomy through the floor was done/attempted. In selected cases, where the floor was not conducive for a ventriculostomy owing to scarring, hypervascularity, a narrow prepontine cistern, or in cases with significant basal exudates (as in tuberculous meningitis [TBM]), an alternative approach was attempted via the LT. The distal end of the sheath of the scope was stationed at the foramen of Monroe. A 4-mm flexible neuroendoscope (Karl Storz) was passed through the sheath, the end was maneuvered anteriorly to visualize the optic chiasma, and the LT was identified anterosuperior to it. The trajectory of the flexible endoscope is depicted in [Figure 2]. If the LT was thin, anterior cerebral arteries could also be visualized through it. Fenestration was done with low setting monopolar current passed through the endoscope, and then the stoma was dilated with the help of either the grasping forceps or a 3F Fogarty catheter [Figure 3]. Alternatively, in cases of a large foramen of Monro, after making the stoma, the flexible scope was removed, a 30° rigid scope was passed, and the stoma was dilated with a curved-tip Fogarty catheter (created by bending the same in vitro). Following this procedure, a flexible scope was introduced again to visualize the stoma and the LT. Unlike the standard third ventriculostomy through the floor, where the end point of surgery is the visualization of the basilar artery, in ETV-LT, the end point is the visualization of anterior cerebral arteries [Figure 4],[Figure 5],[Figure 6],[Figure 7],[Figure 8]. At the end of surgery, the scope was removed and the scalp wound closed after placing a reservoir. The latter is the standard practice at our place for controlled CSF tapping to prevent an early CSF leak through the wound.
Figure 2: Trajectory for the standard third ventriculostomy depicted by the brown line; and, for lamina terminalis third ventriculostomy depicted by the black line

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Figure 3: Stoma enlarged with a Fogarty catheter

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Figure 4: The end point of surgery is the visualization of the anterior cerebral artery

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Figure 5: A narrow prepontine space

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Figure 6: Post-TBM: Significant basal exudates so that third ventricular floor cannot be identified

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Figure 7: Post-infectious neovascularization, and prominent vascularity precludes a safe third ventriculostomy through the floor

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Figure 8: Post-meningitic scarring: Normal anatomy of the third ventricular floor could not be identified for a safe conventional third ventriculostomy

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 » Results Top


Among the eight patients who underwent an ELTV, four had aqueductal stenosis, three had post-tuberculous meningitic hydrocephalus (confirmed on CSF evaluation), and one had a posterior fossa tumor.

In case 1 and 8, even though a stoma was created in the third ventricular floor (the standard ETV), the basilar artery was not clearly seen in case 1, and pulsations of the floor were reduced and unsatisfactory in case 8. The age, sex, presenting symptoms, imaging findings, reasons for LT fenestration, outcome, and follow-up of our patients are depicted in [Table 1].
Table 1: The age, clinical features, diagnosis, surgical procedures performed, intraoperative findings, reason for trans-lamina terminalis (LT) third ventriculostomy, and follow-up duration of the patients

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Requirement of a subsequent diversionary procedure/s was considered as a failure of ETV through LT (ETV-LT). Using the above criteria, ETV-LT was successful in 6 of our patients at a 1.5 year follow-up. Two patients required a subsequent ventriculoperitoneal shunt. An intraoperative complication was seen in one patient in the form of minor contusion to the fornix.


 » Discussion Top


A standard ETV through the floor of the third ventricle has become the standard of care in the management of obstructive hydrocephalus across the world. There are, however, situations where this seemingly easy procedure may not be feasible from a technical point of view. These subset of patients have either a narrow prepontine cistern, a vascularized third ventricular floor, prominent blood vessels coursing just beneath the premamillary membrane, thickened and ill-defined third ventricular floor, and distorted floor anatomy.[4]

The alternative sites for a third ventriculostomy include the LT, the lateral recess in close proximity to the posterior cerebral artery, and the suprapineal recess.[4] LT fenestration can be done through various routes, that is, endoscopic transventricular and transforaminal, endoscopic subfrontal, or the microscopic subfrontal or frontotemporal approach.

Oertel et al., described the risk of forniceal injury while maneuvering the rigid endoscope through the foramen of Monro to the LT region.[2] The working sheath was guided anteriorly, passing over the infundibular recess to identify the optic chiasma and the anterior cerebral arteries. A blunt perforation was made between the anterior cerebral arteries, and the opening was further enlarged with the perforation forceps and a balloon catheter. The problem was that a rigid endoscope could be used only in cases of an enlarged foramen of Monro. Maneuvering the rigid scope through the foramen of Monro entailed a great deal of handling of the fornices with subsequent injury to them. To circumvent this unique issue, we used a flexible scope while following the same technique advocated by Oertel et al. Hence, the status of the foramen of Monro did not actually matter to us.

Rangel-Castilla et al., have shown a 76% rate of resolution of symptoms by the ETV-LT approach;[4] a similar success rate (75%) was found in our case series. In the present series, the only complication that we encountered was a minor ependymal injury in proximity to the fornix which luckily did not result in any long-term sequelae.

In patients suffering from a chronic phase of inflammatory pathology such as tuberculous meningitis, the presence of thick basal exudates or post-inflammatory scarring often leads to the obliteration of the basal cisterns that limits the CSF flow through a standard third ventriculostomy. This has often been described as an extraventricular, intracisternal obstructive hydrocephalus. LT fenestration is more successful because the suprachiasmatic cisterns are infrequently involved by the basal exudates. This route, therefore, allows an unhindered passage of the third ventricular CSF through the supra chiasmatic cistern to the arachnoidal granulations and finally into the venous circulation. The overall success rate for an ETV in patients with TBM-associated hydrocephalus, as reported in large series, is approximately 70%.[7]

The subfrontal supraciliary suprapineal approach has been described by various authors in cadavers as well as in live patients that also has a successful outcome.[5],[6],[8],[9] The technique is feasible and is reliable in providing an alternative site for the ventriculostomy despite the presence of the prominent deep venous complex in this area. Chen et al., have advocated a post-coronal burr hole for a better approach to the LT region.[10] A flexible scope allowed us to avoid a post-coronal burrhole (as the latter can lead to motor weakness on the contralateral side). The technique we described has the advantage that the decision to utilize this approach may be taken intraoperatively especially if the preoperative imaging does not suggest any obvious abnormality of the third ventricular floor. It also obviates excessive manipulation of the rigid scope at the foramen of Monroe which may cause injury to the fornix. Whenever required, the choroid plexus can also be simultaneously coagulated and a ventricular wash concomitantly performed under supervision.

The series we presented is the first report of an ETV-LT using a flexible endoscope via a precoronal burrhole. We would like to acknowledge certain limitations of this procedure. First, the learning curve for neuroendoscopy, particularly with the flexible endoscope, is steep; and second, it is feasible only if the expertise and instruments are available. A larger study sample and further research would be required to delineate the success of transventricular transforaminal ETV via the LT approach.

ETV-LT is a feasible and safe alternative to a standard ETV and allows one to create an alternative, and yet a very effective, CSF egress route with minimal complications. It is useful when the third ventricular floor opening cannot be done owing to a narrow prepontine interval, vascularized third ventricular floor, presence of prominent blood vessels, significant basal exudates, thickened and ill-defined third ventricular floor, and distorted floor anatomy. The use of flexible neuroendoscope makes the procedure easy as well as safe by preventing the potential forniceal injury that can happen with the rigid endoscopes.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
 » References Top

1.
Schroeder HW, Oertel J, Gaab MR. Endoscopic treatment of cerebrospinal fluid pathway obstructions. Neurosurgery 2008;62(Suppl 3):1084-92.  Back to cited text no. 1
    
2.
Oertel JM, Vulcu S, Schroeder HW, Konerding MA, Wagner W, Gaab MR. Endoscopic transventricular third ventriculostomy through the lamina terminalis. J Neurosurg 2010;113:1261-9.  Back to cited text no. 2
    
3.
Vulcu S, Tschabitscher M, Mueller-Forell W, Oertel J. Transventricular fenestration of the lamina terminalis: The value of a flexible endoscope: Technical note. J Neurol Surg A Cent Eur Neurosurg 2014;75:207-16.  Back to cited text no. 3
    
4.
Rangel-Castilla L, Hwang SW, Jea A, Torres-Corzo J. Efficacy and safety of endoscopic transventricular lamina terminalis fenestration for hydrocephalus. Neurosurgery 2012;71:464-73.  Back to cited text no. 4
    
5.
Abdou MS, Cohen AR. Endoscopic surgery of the third ventricle: The subfrontal trans-lamina terminalis approach. Minim Invasive Neurosurg 2000;43:208-11.  Back to cited text no. 5
    
6.
Spena G, Fasel J, Tribolet Nd, Radovanovic I. Subfrontal endoscopic fenestration of lamina terminalis: An anatomical study. Minim Invasive Neurosurg 2008;51:319-23.  Back to cited text no. 6
    
7.
Chugh A, Husain M, Gupta RK, Ojha BK, Chandra A, Rastogi M. Surgical outcome of tuberculous meningitis hydrocephalus treated by endoscopic third ventriculostomy: Prognostic factors and postoperative neuroimaging for functional assessment of ventriculostomy. J Neurosurg Pediatr 2009;3:371-7.  Back to cited text no. 7
    
8.
Meybodi AT, Miri SM. Microscopic supraciliary approach for terminal laminotomy for treatment of hydrocephalus: A preliminary report of eight cases. Turk Neurosurg 2012;22:599-603.  Back to cited text no. 8
    
9.
Daniel RT, Gabriel, Lee GY, Reilly PL. Suprapineal recess: An alternate site for third ventriculostomy? Case report. J Neurosurg 2004;101:518-20.  Back to cited text no. 9
    
10.
Chen F, Chen T, Nakaji P. Adjustment of the endoscopic third ventriculostomy entry point based on the anatomical relationship between coronal and sagittal sutures. J Neurosurg 2013;118:510-3.  Back to cited text no. 10
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4], [Figure 5], [Figure 6], [Figure 7], [Figure 8]
 
 
    Tables

  [Table 1]

This article has been cited by
1 Effectiveness of Intraventricular Endoscopic Lamina Terminalis Fenestration in Comparison with Standard ETV: Systematic Review of Literature
Carlo Giussani,Lelio Guida,Andrea Trezza,Erik Pietro Sganzerla
World Neurosurgery. 2017; 103: 257
[Pubmed] | [DOI]



 

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