Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 31  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (474 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References

 Article Access Statistics
    Viewed1531    
    Printed18    
    Emailed0    
    PDF Downloaded48    
    Comments [Add]    

Recommend this journal

 


 
Table of Contents    
CORRESPONDENCE
Year : 2016  |  Volume : 64  |  Issue : 4  |  Page : 841-842

Achalasia and amyotrophic lateral sclerosis as part of Allgrove syndrome


Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India

Date of Web Publication5-Jul-2016

Correspondence Address:
Manoj Goyal
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.185368

Rights and Permissions



How to cite this article:
Jain G, Choudhary A, Goyal M, Lal V. Achalasia and amyotrophic lateral sclerosis as part of Allgrove syndrome. Neurol India 2016;64:841-2

How to cite this URL:
Jain G, Choudhary A, Goyal M, Lal V. Achalasia and amyotrophic lateral sclerosis as part of Allgrove syndrome. Neurol India [serial online] 2016 [cited 2019 Nov 18];64:841-2. Available from: http://www.neurologyindia.com/text.asp?2016/64/4/841/185368


Sir,

We have read the recently published manuscript written by Mahale et al.,[1] and appreciate the insight that the authors provide in considering alternate possibilities in patients presenting with dysphagia in limb onset amyotrophic lateral sclerosis. However, it is pertinent to note that upper and lower motor neuron involvement can be a presenting feature of Allgrove's syndrome.[2] Allgrove or triple A syndrome is a rare autosomal recessive disease caused by a mutation in the gene encoding protein ALADIN, and though common in children, it can also present in adulthood.[3] The syndrome is characterized by achalasia, alacrima, adrenal insufficiency, autonomic dysfunction, and amyotrophy.[4] We feel that it would be worthwhile to look for other symptoms of the triple A syndrome in the concerned patients such as alacrima and adrenal insufficiency.[5]

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Mahale R, Mehta A, Kempegowda MB, Javali M, Rangasetty S. Achalasia cardia causing dysphagia in amyotrophic lateral sclerosis. Neurol India 2015;63:989-91.  Back to cited text no. 1
[PUBMED]  Medknow Journal  
2.
Messina MF, Autunno M, Koehler K, Russo M, Arrigo T, Crisafulli G, et al. Upper and lower motor neuron involvement as presenting manifestation of triple A syndrome. J Endocrinol Invest 2009;32:482-3.  Back to cited text no. 2
[PUBMED]    
3.
Nakamura K, Yoshida K, Yoshinaga T, Kodaira M, Shimojima Y, Takei Y, et al. Adult or late-onset triple A syndrome: Case report and literature review. J Neurol Sci 2010;297:85-8.  Back to cited text no. 3
    
4.
Vishnu VY, Modi M, Prabhakar S, Bhansali A, Goyal MK. “A” motor neuron disease. J Neurol Sci 2014;336:251-3.  Back to cited text no. 4
    
5.
Strauss M, Koehler K, Krumbholz M, Huebner A, Zierz S, Deschauer M. Triple A syndrome mimicking ALS. Amyotroph Lateral Scler 2008;9:315-7.  Back to cited text no. 5
    




 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow