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Year : 2016  |  Volume : 64  |  Issue : 5  |  Page : 906--911

Polymyalgia rheumatica and risk of cerebrovascular accident: A systematic review and meta-analysis

1 Department of Internal Medicine, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA; Department of Medicine, Division of Rheumatology, Siriraj Hospital, Mahidol University, Bangkok, Thailand
2 Division of Pulmonology and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA
3 Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota, USA

Correspondence Address:
Patompong Ungprasert
Division of Rheumatology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota - 55905

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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.190273

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Background: Several chronic inflammatory disorders, such as rheumatoid arthritis and systemic lupus erythematosus, have been linked to an increased risk of cerebrovascular accident (CVA), but the data on polymyalgia rheumatica (PMR) remains unclear. Materials and Methods: We conducted a systematic review and meta-analysis of observational studies that reported odds ratio, relative risk, hazard ratio, or standardized incidence ratio comparing the risk of CVA in patients with PMR versus non-PMR controls. Pooled risk ratio and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method of DerSimonian and Laird. Results: Three retrospective cohort studies and one cross-sectional study were identified and included in the data analysis. We found a significantly elevated CVA risk in patients with PMR, with the pooled risk ratio of 1.87 (95% CI, 1.43–2.43). The statistical heterogeneity was high, with an I2 of 91%. Conclusions: Our study demonstrated a statistically significantly increased CVA risk among patients with PMR.


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Online since 20th March '04
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