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Year : 2016  |  Volume : 64  |  Issue : 6  |  Page : 1187--1192

Acute disseminated encephalomyelitis: A clinical and neuroradiological profile of pediatric patients

1 Department of Pediatrics, Institute of Child Health, Kolkata, West Bengal, India
2 Department of Pediatric Radiology and Imaging, Institute of Child Health, Kolkata, West Bengal, India
3 Department of Pediatric Neurology, Institute of Child Health, Kolkata, West Bengal, India

Correspondence Address:
Dr. Prabhas Prasun Giri
Flat C1, Anandan, 173, Sarat Ghosh Garden Road, Dhakuria, Kolkata - 700 031, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.193808

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Objectives: To discuss the clinical and neuroradiological profile of pediatric patients with acute disseminated encephalomyelitis (ADEM). Design: Prospective observational study Settings: Children with clinico-radiological diagnosis of ADEM admitted in the pediatric ward of the Institute of Child Health between July 2009 to Sepetember 2014 were included. Materials and Methods: Clinical and neuroradiological parameters of children suffering from ADEM were noted. Results: A total of 36 children were included in the study, among whom approximately 50% had a history of either a preceding viral infection or the administration of a vaccination; and, 92% of them presented with some form of neurological deficits. Encephalopathy was present in 92% children at the time of admission. Seizures were present in 42% of children. The cerebrospinal fluid (CSF) study was non-contributory and magnetic resonance imaging (MRI) was diagnostic in most of the cases. The lesions were usually asymmetrically placed. All of them were treated with steroids and had a good prognosis, with complete neurological recovery in 75% of the children. Conclusion: Although it is perceived as a rare disease, ADEM is fairly common in the pediatric population, Most often, it is misdiagnosed as a meningoencephalitis. An early neuroradiological identification of the demyelinating lesions and treatment with steroid therapy leads to an excellent outcome.


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