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Table of Contents    
Year : 2018  |  Volume : 66  |  Issue : 1  |  Page : 268

Reversible symptoms present in a patient with Balo's concentric sclerosis

1 Department of Neurology, University Clinical Hospital, Wroclaw, Poland
2 Department of Neurology, Wroclaw Medical University, Wroclaw, Poland
3 Department of Radiology, Wroclaw Medical University, Wroclaw, Poland

Date of Web Publication11-Jan-2018

Correspondence Address:
Dr. Edyta Dziadkowiak
Wroclaw Medical University, 213 Street Borowska, Wroclaw – 50-556
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.222885

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How to cite this article:
Dziadkowiak E, Zagrajek M, Zimny A, Paradowski B. Reversible symptoms present in a patient with Balo's concentric sclerosis. Neurol India 2018;66:268

How to cite this URL:
Dziadkowiak E, Zagrajek M, Zimny A, Paradowski B. Reversible symptoms present in a patient with Balo's concentric sclerosis. Neurol India [serial online] 2018 [cited 2020 May 30];66:268. Available from:

A 43-year old woman presented with flu-like symptoms without fever, followed by bulbar palsy. Magnetic resonance imaging revealed two symmetrical, non-enhancing, T2-hyperintense, oval, frontal subcortical lesions showing an onion-skin-like pattern [Figure 1]. Cerebrospinal fluid examination showed lymphocytic pleocytosis (10/mm3) with no immunoglobulin G oligoclonal bands. Serological tests for viruses, Lyme disease, tumor markers, antinuclear antibodies, and antibodies to aquaporin-4 water channels were negative. Pattern visual evoked potential (VEP) and the analysis of electroencephalography (EEG) data were normal. Steroid therapy resolved all symptoms. Balo's concentric sclerosis is a rare variant of multiple sclerosis.[1] Concentric lesions are probably due to a reaction to an unknown neurochemical agent.[1],[2]
Figure 1: Magnetic resonance images showing two acute, symmetrical, frontal subcortical lesions with concentric layers of demyelination and preserved myelin clearly visible on T2-weighted images (a) and diffusion weighted images [DWI] (b), with restricted diffusion on DWI (b) and hypoperfusion on perfusion-weighted images (c), which regressed markedly three months later (d)

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Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

  References Top

Hardy TA, Reddel SW, Barnett MH, Palace J, Lucchinetti CF, Weinshenker BG. Atypical inflammatory demyelinating syndromes of the CNS. Lancet Neurol 2016;15:967-81.  Back to cited text no. 1
Barz H, Barz U, Schreiber A. Morphogenesis of the demyelinating lesions in Baló's concentric sclerosis. Med Hypotheses 2016;91:56-61.  Back to cited text no. 2


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