Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 3497  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (503 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

  In this Article

 Article Access Statistics
    PDF Downloaded14    
    Comments [Add]    

Recommend this journal


Table of Contents    
Year : 2018  |  Volume : 66  |  Issue : 1  |  Page : 284-285

Authors' Reply: Arterial spin labeling: Clarifying the apparent contradiction

1 Department of Radiology, Global Hospitals, Mumbai, S.L. Raheja - Fortis Associate Hospital, Mumbai, Maharashtra, India
2 Wipro GE Healthcare, Bengalaru, Karnataka, India

Date of Web Publication11-Jan-2018

Correspondence Address:
Dr. Sona A Pungavkar
Department of Radiology, Global Hospitals, Mumbai, Maharashtra
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.222839

Rights and Permissions

How to cite this article:
Pungavkar SA, Awasthi R. Authors' Reply: Arterial spin labeling: Clarifying the apparent contradiction. Neurol India 2018;66:284-5

How to cite this URL:
Pungavkar SA, Awasthi R. Authors' Reply: Arterial spin labeling: Clarifying the apparent contradiction. Neurol India [serial online] 2018 [cited 2019 Jun 26];66:284-5. Available from:

The apparent contradiction between our study [1] and that of Patel et al.,[2] regarding signal-to-noise ratio, lower temporal and spatial resolution and greater susceptibility artefact from the metallic hardware, blood, large vessels and air interfaces [3] arises from the fact that different vendors have variability in the pulse sequence used for arterial spin labeling (ASL). We performed our study on a 3T scanner with a 19-element coil, which has a decent signal-to-noise ratio. The vendor-provided ASL sequence is a fast spin echo (FSE) based readout, hence our observations viz a viz dynamic susceptibility contrast (DSC) perfusion is that ASL has less susceptibility artifact. The labeling technique used also plays an important role in the quality/accuracy of the generated cerebral blood flow (CBF) maps; in our case, pseudo-continuous labeling was used which gives better signal-to –noise ratio (SNR) and labeling efficiency as compared to pulsed or continuous labeling.

Another important point is the availability of approved clinical sequences for wider reach among clinicians and radiologists as compared to the research prototype sequences. Since ASL is very new to the clinical arena with variability in type of acquisition among different vendors, it will take some time to gain acceptance. Our observations suggest that it can be useful in different pathologies with just-a-few-minutes time penalty. Being a non-contrast based imaging, the sequence can be performed in any patient who is undergoing a magnetic resonance (MR) exam.

The utility of superselective ASL appears to be exciting; however, we do not have any experience in the utilization of this technique as it is not available for clinical use on our scanner.

Financial support and sponsorship


Conflicts of interest

There are no conflicts of interest.

  References Top

Pungavkar SA, Yanamandala R. Arterial spin labeling: A novel promising perfusion technique-Can it be a replacement to dynamic susceptibility contrast MRI ? Neurol India 2017;65:979-81.  Back to cited text no. 1
[PUBMED]  [Full text]  
Patel MD, Sawlani V. Can arterial spin labeling really replace dynamic susceptibility contrast perfusion techniques for assessing brain tumours in clinical practice? Neurol India 2017;65:977-8.  Back to cited text no. 2
[PUBMED]  [Full text]  
Amukotuwa SA, Yu C, Zaharchuk G. 3D pseudocontinuous arterial spin labeling in routine clinical practice: A review of clinically significant artifacts. J Magn Reson Imaging 2016;43:11-27.  Back to cited text no. 3


Print this article  Email this article
Online since 20th March '04
Published by Wolters Kluwer - Medknow