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|Year : 2018 | Volume
| Issue : 5 | Page : 1524
Addition of pyridoxine to prednisolone in the treatment of infantile spasms: The knowledge gaps
Arundhati Banerjee, Lokesh Saini
Pediatrics Neurology Unit, Post Graduate Medical Education and Research, Chandigarh, India
|Date of Web Publication||17-Sep-2018|
Dr. Lokesh Saini
Pediatrics Neurology Unit, Post Graduate Medical Education and Research, Chandigarh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Banerjee A, Saini L. Addition of pyridoxine to prednisolone in the treatment of infantile spasms: The knowledge gaps. Neurol India 2018;66:1524
I read with interest the recent article entitled “Addition of pyridoxine to prednisolone in the treatment of infantile spasms: A pilot randomized controlled trial” published in Neurology India in March 2018. I would like to congratulate the authors on their endeavour to explore a novel treatment by adding pyridoxine as an adjunct to the standard parenteral adrenocorticotrophic hormonal therapy in the treatment of West syndrome. This is an area of research where there is significant gap in knowledge among pediatricians and the subject also lacks quality evidence-base.,
There are a few points that I would like to highlight in the study. The authors have mentioned having used high dose pyridoxine even though their methodology states that pyridoxine has been used in a dose of 30 mg/kg/day. The mentioned dose does not qualify as being a high dose, in its strict sense. The criterion for a high dose has been mentioned as 0.2-0.4 mg/kg/day in the Japanese literature. In this regard, the paper of Pietze et al., from Germany has been erroneously cited, as the dose of pyridoxine used in the latter study was 300 mg/kg/day and not 300 mg/day as mentioned in the paper. Besides, the authors have also used the criterion of ‘2 weeks after the starting of treatment' as the point of assessment of complete cessation. This, we feel, should be revised. This is because the West Delphi consensus clearly defines that complete cessation of infantile spasms should be ascertained at 2 weeks. Moreover, their cessation should be maintained for a period of 28 days from the last noted spasm. Hence, it would have been more pragmatic to use the 6-week post-treatment evaluation as the point of assessment of the primary outcome of the study.
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| » References|| |
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