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|Year : 2018 | Volume
| Issue : 5 | Page : 1525
Pituitary aspergillosis: A report and review of the literature
Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq
|Date of Web Publication||17-Sep-2018|
Dr. Mahmood Dhahir Al-Mendalawi
Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, P.O. Box. 55302, Baghdad, Baghdad
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Al-Mendalawi MD. Pituitary aspergillosis: A report and review of the literature. Neurol India 2018;66:1525
I refer to the interesting case report published by Divyashree et al. on pituitary aspergillosis (PA) in an Indian patient. I assume that the development of PA in the studied patient could not be solely attributed to the underlying diabetes-associated jeopardized immunity. Among the important immunocompromised states that needed to be considered, infection with human immunodeficiency virus (HIV) was of utmost importance. My assumption is based on the following point. It is obvious that due to jeopardized immunity, HIV- infected individuals are more vulnerable to a wide range of bacterial, fungal, and parasitic infections compared to the immunocompetent individuals. Among fungal infections, aspergillosis has been reported in HIV-positive patients. Studying central nervous system fungal infections in India has shown that 34% of infections were due to cryptococcosis and 16% of cases were due to aspergillosis. Interestingly, 28% of cases were having an immunocompetent and 72% were having an immunocompromised status. To my knowledge, HIV infection is a distressing health problem in India. The published data pointed to a 0.26% HIV seroprevalence compared with a global average of 0.2%. I assume that the rare occurrence of PA should immediately alert the authors to define the HIV status in the studied patient. Hence, an initiation of the diagnostic workup involving the blood CD4 lymphocyte count and viral overload estimation was solicited. If that workup would have revealed HIV seropositivity, the case in question would have pointed to the presence of of HIV- associated aspergillosis that has until now rarely been reported in the Indian literature.
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| » References|| |
Divyashree S, Karthik R, Prabhu K, Chacko G. Pituitary aspergillosis: A report and review of the literature. Neurol India 2018;66:1176-8.
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