Atormac
Neurology India
menu-bar5 Open access journal indexed with Index Medicus
  Users online: 5788  
 Home | Login 
About Editorial board Articlesmenu-bullet NSI Publicationsmenu-bullet Search Instructions Online Submission Subscribe Videos Etcetera Contact
  Navigate Here 
 Search
 
  
 Resource Links
    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Article in PDF (441 KB)
    Citation Manager
    Access Statistics
    Reader Comments
    Email Alert *
    Add to My List *
* Registration required (free)  

 
  In this Article
   References

 Article Access Statistics
    Viewed141    
    Printed3    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal

 


 
Table of Contents    
NI FEATURE: THE EDITORIAL DEBATE IV-- PROS AND CONS
Year : 2019  |  Volume : 67  |  Issue : 3  |  Page : 662-663

Chiari I malformation: Surgical considerations


Department of Neurosurgery, University of Texas Medical Branch at Galveston, Galveston, Texas, USA

Date of Web Publication23-Jul-2019

Correspondence Address:
Dr. Aaron Mohanty
Department of Neurosurgery, 301 University Boulevard, 9.204, Galveston, Texas 77555
USA
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.263222

Rights and Permissions



How to cite this article:
Mohanty A. Chiari I malformation: Surgical considerations. Neurol India 2019;67:662-3

How to cite this URL:
Mohanty A. Chiari I malformation: Surgical considerations. Neurol India [serial online] 2019 [cited 2019 Aug 24];67:662-3. Available from: http://www.neurologyindia.com/text.asp?2019/67/3/662/263222




Since the initial studies by Williams in the 1990s, crowding at the region of the foramen of magnum associated with cerebrospinal fluid (CSF) flow disturbances has been thought to be the pathophysiology of  Chiari malformation More Details and associated syringomyelia. Considering this, foramen magnum decompression, removal of the posterior arch of  Atlas More Details with various modes of posterior fossa dural expansion, has remained the mainstay of treatment of Chiari malformation for the past several decades. The overall results of bone decompression and duroplasty have been quite reproducible in various studies, making this procedure the first line of treatment in symptomatic patients. Syringomyelia often coexists with Chiari malformation, and the incidence has been reported to be as high as 22% in some studies. Associated syringomyelia in the cervical and often in the thoracic spine has been thought to be a progression of the pathophysiological abnormalities in the region of the craniovertebral junction associated with Chiari malformation.

Several diagnostic and management controversies are associated in the management of Chiari malformation. With a poorly documented natural history, the patients with asymptomatic Chiari malformation often present diagnostic and therapeutic dilemmas. With a magnetic resonance imaging (MRI) incidence of around 1%, it is not uncommon to have mild or moderate tonsillar descent in patients who are asymptomatic or are vaguely symptomatic. In addition, the extent of tonsillar herniation often poorly correlates with the type and severity of clinical manifestations. The degree of tonsillar descent has been found to change with time in nonoperated children; a recent study reported a reduction of a few millimeters in 38%, worsening in 12%, while it remained status quo in the rest of 50% patients over a 7-year follow-up period.[1]

The not completely understood pathogenesis for Chiari and associated syringomyelia leads to controversy in the nature and extent of surgical management. The predominant discussion has been the extent of decompression and performance of duroplasty. It is well agreed that the three major complications of Chiari surgery – CSF leak, rescarring causing recurrence of the symptoms, and posterior fossa aseptic meningitis – are associated with dural opening and can be avoided with extradural decompression or partial-thickness dural opening. Decompression without duroplasty has also been found to have a shorter operative time, a shorter length of stay, and a lower total cost of initial hospitalization.[2] A meta-analysis of 582 patients found equivalent outcome with respect to the resolution of symptoms and syringomyelia after Chiari decompression with and without expansile duroplasty.[3] The duroplasty group, however, required a lower reoperation rate but had a higher incidence of CSF leak. In another study of 156 children, about 90% had improvement or resolution of symptoms following posterior fossa decompression without dural opening. No patients with less than 8 mm descent required reoperation, while patients with tonsillar descent till the mid or inferior margin of C2 required re-surgery. This observation of failure of limited posterior fossa expansion in patients without duroplasty with a significant tonsillar herniation has also been acknowledged by others.[4] Some have reserved it only for patients without syringomyelia.[2] In a survey of pediatric neurosurgeons pertaining to symptomatic Chiari 1 malformation, most considered duroplasty as the primary option, although 6% mentioned that they would avoid a duroplasty and another 6% indicated using ultrasound guidance to decide on duroplasty. An associated syrinx reduced the incidence of the two later groups from 6% to 4%.[5]

In the recent years, attention has been focused towards the associated bony abnormalities and craniovertebral junction abnormality in Chiari I malformation.[6] Association of craniovertebral junction abnormality predisposes to instability in the region which may require a fusion. Basilar invagination, which may be associated in up to 38% of cases, would require craniovertebral junction stabilization. Ventral brain stem compression by a retroflexed odontoid is often observed in about 20% of cases. The amount of retroflexion of the odontoid is measured by a pB-C2 line and is used to predict the necessity of a fusion. A line is drawn extending from the basion to the posterior and inferior point of the body of C2 (B-C2 line); the pB-C2 is the perpendicular distance between the ventral dura and the B-C2 line. A pB-C2 distance of more than 9 mm has been found to be associated with a symptomatic ventral brainstem compression and craniovertebral junction abnormality requiring fusion.[7] Another measurement, the clivoaxial angle, is the angle formed by Wackenheim's clivus base line and the line drawn along the posterior surface of C2 and odontoid process. A clivoaxial angle of 145–160° in a neutral position is considered to be normal. The clivoaxial angle reduces by about 10° in flexion and increases by 10° in extension. An angle of less than 125° has been associated with the requirement for a stabilization procedure.[8] In addition, patients who have associated brain stem herniation through the foramen magnum (Chiari 1.5, where the obex is located below the level of foramen magnum associated with tonsillar herniation, in the preoperative MRI) may require a a fusion. Moreover, association of genetic syndromes such as Ehlers–Danlos syndrome, Marfans syndrome, and Down's syndrome has also been associated with craniovertebral junction abnormality.

In Chiari malformation, the tonsillar descent with crowding in the region of the foramen magnum obstructs the normally observed rapid bidirectional CSF flow occurring during the cardiac cycle. This obstruction has been postulated to result in greater cervical subarachnoid pressure waves which compress the spinal cord and force the CSF to enter into the spinal cord through the perivascular spaces, thus initiating and propagating the syrinx.[9] Considering this, several studies have described the CSF flow characteristics in patients with Chiari I malformation – either by radionuclide cisternogram [10] or with cine-flow MRI.[11],[12] Some of them have attempted to measure the CSF flow velocities in the region of foramen magnum across the obstruction in the pre- and postoperative period.[11] A heterogeneous pattern of CSF flow with regions of increased CSF velocity (CSF velocity jets) and regions of reduced velocity, has been described in the preoperative imaging.[11] With decompression, the flow pattern returns to the normal sinusoidal pattern with reduction in the velocity of the flow.[11] The results have revealed improvement of the varied, heterogeneous CSF flow with some authors finding its correlation with the outcome.[9],[13] However, studies have failed to find a CSF flow characteristic which may consistently differentiate between symptomatic, and asymptomatic or mildly symptomatic patients.

The authors of the study reported in this issue found a decrease in the peak CSF velocity at the foramen magnum following foramen magnum decompression without duroplasty, at 6 months of follow-up.[14] However, on analyzing the CSF flow velocity, they did not find any correlation between the changes in maximal CSF velocities and the degree of clinical improvement. The authors suggest that the degree of CSF flow obstruction should be considered as a criterion for the preoperative selection of patients for posterior fossa decompression. In the future, it would be interesting to see whether the criteria based on the preoperative cine MRI findings would suggest the nature and extent of surgical intervention for a given patient.



 
  References Top

1.
Whitson WJ, Lane JR, Bauer DF, Durham SR. A prospective natural history study of nonoperatively managed Chiari I malformation: Does follow-up MRI surveillance alter surgical decision making? J Neurosurg Pediatr 2015;16:159-66.  Back to cited text no. 1
    
2.
Litvack ZN, Lindsay RA, Selden NR. Dura splitting decompression for Chiari I malformation in pediatric patients: Clinical outcomes, healthcare costs, and resource utilization. Neurosurgery 2013;72:922-8.  Back to cited text no. 2
    
3.
Durham SR, Fjeld-Olenec K. Comparison of posterior fossa decompression with and without duraplasty for the surgical treatment of Chiari malformation Type I in pediatric patients: A meta-analysis. J Neurosurg Pediatr 2008;2:42-9.  Back to cited text no. 3
    
4.
Chauvet D, Carpentier A, George B. Dura splitting decompression in Chiari type 1 malformation: Clinical experience and radiological findings. Neurosurg Rev 2009;32:465-70.  Back to cited text no. 4
    
5.
Rocque BG, George TM, Kestle J, Iskandar BJ. Treatment practices for Chiari malformation type I with syringomyelia: Results of a survey of the American Society of Pediatric Neurosurgeons. J Neurosurg Pediatr 2011;8:430-7.  Back to cited text no. 5
    
6.
Goldstein HE, Anderson RC. Craniovertebral junction instability in the setting of Chiari I malformation. Neurosurg Clin N Am 2015;26:561-9.  Back to cited text no. 6
    
7.
Grabb PA, Mapstone TB, Oakes WJ. Ventral brain stem compression in pediatric and young adult patients with Chiari I malformations. Neurosurgery 1999;44:520-7.  Back to cited text no. 7
    
8.
Bollo RJ, Riva-Cambrin J, Brockmeyer MM, Brockmeyer DL. Complex Chiari malformations in children: An analysis of preoperative risk factors for occipitocervical fusion. J Neurosurg Pediatr 2012;10:134-41.  Back to cited text no. 8
    
9.
Heiss JD, Patronas N, DeVroom HL, Shawker T, Ennis R, Kammerer W, et al. Elucidating the pathophysiology of syringomyelia. J Neurosurg 1999;91:553-62.  Back to cited text no. 9
    
10.
Arora P, Pradhan PK, Behari S, Banerji D, Das BK, Chhabra DK, et al. Chiari I malformation related syringomyelia: Radionuclide cisternography as a predictor of outcome. Acta Neurochir (Wien) 2004;146:119-30.  Back to cited text no. 10
    
11.
Iskandar BJ, Quigley M, Haughton VM. Foramen magnum cerebrospinal fluid flow characteristics in children with Chiari I malformation before and after craniocervical decompression. J Neurosurg 2004;101 (2 Suppl):169-78.  Back to cited text no. 11
    
12.
Koç K, Anik Y, Anik I, Cabuk B, Ceylan S. Chiari 1 malformation with syringomyelia: Correlation of phase-contrast cine MR imaging and outcome. Turk Neurosurg 2007;17:183-92.  Back to cited text no. 12
    
13.
Bhadelia RA, Bogdan AR, Wolpert SM, Lev S, Appignani BA, Heilman CB. Cerebrospinal fluid flow waveforms: Analysis in patients with Chiari I malformation by means of gated phase contrast MR imaging velocity measurements. Radiology 1995;196:195-202.  Back to cited text no. 13
    
14.
Kumar A, Ghosh SN, Sadique SI. Clinicoradiological study of adult Chiari malformation type 1 patients with emphasis on cerebrospinal fluid peak flow velocity at foramen magnum level. Neurol India 2019;67:744-8.  Back to cited text no. 14
  [Full text]  




 

Top
Print this article  Email this article
   
Online since 20th March '04
Published by Wolters Kluwer - Medknow