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Table of Contents    
LETTERS TO EDITOR
Year : 2019  |  Volume : 67  |  Issue : 4  |  Page : 1142

Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation


1 Medical Center, Sanitation, Medical Academic Center, Bangkok, Thailand
2 Visiting Professor, Hainan Medical University, Haikou, China

Date of Web Publication10-Sep-2019

Correspondence Address:
Dr. Beuy Joob
Sanitation, Medical Academic Center, Bangkok
Thailand
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.266266

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How to cite this article:
Joob B, Wiwanitkit V. Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation. Neurol India 2019;67:1142

How to cite this URL:
Joob B, Wiwanitkit V. Cyclooxygenase-2 Gene Polymorphisms and Risk of Alzheimer's Disease: A Possible Biomoleular Explanation. Neurol India [serial online] 2019 [cited 2019 Nov 22];67:1142. Available from: http://www.neurologyindia.com/text.asp?2019/67/4/1142/266266




Sir,

Cyclooxygenase-2 (COX-2) is an important enzyme for the synthesis of prostaglandins bioprocess. COX-2 plays a role in inflammation response. There are many reports regarding the relationship between COX-2 and the pathogenesis of Alzheimer's disease (AD). In a recent meta-analysis study by Luo et al., it was concluded that “C-allele of rs20417 (-765G>C) polymorphism was associated with a reduced risk of AD, which might be a protective factor.”[1] Here, the authors used the basic quantum calculation for determining the molecular weight change in G to C type and found that there was a reduction from 151.13 to 111.1. The molecular weight reduction can imply that more energy is required for the biological process of final enzyme reaction or increased difficulty for COX-2 expression. This is concordant with the finding that increased expression of COX-2 was observed in cases with severe AD.[2] In fact, the phenomenon is the same as the molecular weight change described by quantum calculation study in previous reports on disease-related polymorphisms.[3],[4] Hence, the effect of COX-2 polymorphism on AD susceptibility can be confirmed. Nevertheless, it should be noted that there are other genes polymorphisms that might affect the susceptibility for AD. A good example is phospholipase A2 enzyme gene.[5] Clarifying the combinatorial effect among different gene polymorphisms on the susceptibility of AD is very interesting.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Luo D, Long Y, Chen GJ. Cyclooxygenase-2 gene polymorphisms and risk of Alzheimer's disease: A meta-analysis. J Neurol Sci 2015;359:100-5.  Back to cited text no. 1
    
2.
Ho L, Purohit D, Haroutunian V, Luterman JD, Willis F, Naslund J, et al. Neuronal cyclooxygenase 2 expression in the hippocampal formation as a function of the clinical progression of Alzheimer disease. Arch Neurol 2001;58:487-92.s.  Back to cited text no. 2
    
3.
Joob B, Wiwanitkit V. HSD11B1 rs846908 polymorphisms and tacrolimus concentrations: Quantum chemical analysis and implication in patients with renal transplantation. J Nephropharmacol 2016;6:19-20.  Back to cited text no. 3
    
4.
Joob B, Wiwanitkit V. ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) polymorphism and clopidogrel concentration in acute coronary syndrome: Molecular change can explain the observed therapeutic concentration. Anatol J Cardiol 2016;16:303-4.  Back to cited text no. 4
    
5.
Cordeiro Q, Noguti R, Bottino CM, Vallada H. Study of association between genetic polymorphisms of phospholipase A2 enzymes and Alzheimer's disease. Arq Neuropsiquiatr 2010;68:189-93.  Back to cited text no. 5
    




 

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