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 REVIEW ARTICLE
Year : 2019  |  Volume : 67  |  Issue : 4  |  Page : 983--992

The Benefits and Risks of Statin Therapy in Ischemic Stroke: A Review of the Literature


1 Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China
2 Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China

Correspondence Address:
Dr. Shui-Ping Zhao
Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, No. 139 Middle Renmin Road, Changsha, Hunan - 410011
P.R. China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.266274

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Statins are effective cholesterol-lowering drugs for reducing the risks of mortality and morbidity of cardiovascular diseases. Increasing evidence has shown that statin use is associated with a significant beneficial effect in patients with ischemic stroke. Both pre-stroke and post-stroke statin use has been found to be beneficial in ischemic stroke. Furthermore, good adherence is associated with a better clinical outcome, and statin withdrawal is associated with a poor functional outcome in patients with ischemic stroke. High-intensity statin therapy is advocated for the treatment of ischemic stroke. However, there are concerns regarding the adverse effects associated with statin use in ischemic stroke such as intracranial hemorrhage. In this review, we summarize the beneficial effect of statin use in ischemic stroke and discuss the potential risks associated with statin therapy.






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Online since 20th March '04
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