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Year : 2019  |  Volume : 67  |  Issue : 5  |  Page : 1358--1359

An Investigation on the Coinfection of Measles and HSV-1 in Hospitalized Acute Encephalitis Syndrome Patients in Eastern India

1 Virology Division, ICMR-RMRC; Department of Biotechnology, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India
2 Virology Division, ICMR-RMRC; Department of Pediatrics, AIIMS, Bhubaneswar, Odisha, India
3 Virology Division, ICMR-RMRC, Bhubaneswar, Odisha, India
4 Department of Microbiology, Apollo Hospital, Bhubaneswar, Odisha, India
5 IMS and SUM Hospital, Director, Medical Research and Life Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Dr. B Dwibedi
Regional Medical Research Centre, Bhubaneswar - 751 023, Odisha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0028-3886.271247

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Acute encephalitis syndrome (AES) is a clinical condition that occurs due to infectious and noninfectious agents- however, viruses are considered to be the dominant pathogen. agents- however, viruses are considered to be the dominant pathogen. In this study, suspected AES cases were enrolled and tested for viral etiology through serology and polymerase chain reaction (PCR)/reverse transcriptase PCR from August 2012–July 2013. During this period, 820 cases were investigated and 96 cases were diagnosed to have a viral etiology whereas 20 patients had IgM antibodies for measles in serum and HSV-1 DNA in cerebrospinal fluid. All 20 of the patients were children below 14 years of age. The median hospital stay was 15 days (IQR: 14.2-17 days) and median GCS score was 7(IQR: 6–8) and were significantly different with patients with co-infections when comapred with patients having HSV-1 infection only. It may be suspected that the measles infection may have a role in the pathogenesis and thus an impact on the prognosis of the AES when present with HSV-1.


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