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CORRESPONDENCE
Year : 2019  |  Volume : 67  |  Issue : 5  |  Page : 1364

Commentary on Neuroprotective Role of Dexmedetomidine in Epilepsy Surgery


1 Department of Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi, India
2 Department of Anaesthesia, All India Institute of Medical Sciences, Rishikesh, Uttrakhand, India
3 National Institute of Malaria Research, New Delhi, India

Date of Web Publication19-Nov-2019

Correspondence Address:
Dr. Ashish Bindra
Neuroanaesthesiology and Critical Care, All India Institute of Medical Sciences, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.271275

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How to cite this article:
Bindra A, Kaushal A, Yadav CP. Commentary on Neuroprotective Role of Dexmedetomidine in Epilepsy Surgery. Neurol India 2019;67:1364

How to cite this URL:
Bindra A, Kaushal A, Yadav CP. Commentary on Neuroprotective Role of Dexmedetomidine in Epilepsy Surgery. Neurol India [serial online] 2019 [cited 2019 Dec 7];67:1364. Available from: http://www.neurologyindia.com/text.asp?2019/67/5/1364/271275




Sir,

We would like to convey our gratitude to the readers for showing interest in our article. Authors raised a very valid point regarding differences in the baseline values of S100b in the study groups.[1] The point was taken care in the analysis of our study. Baseline S100b level was not comparable between the two groups, therefore, to calculate overall group difference, baseline S100B level was adjusted.[2] For further clarification Stata output is enclosed [Figure 1].
Figure 1: Stata output of the baseline values of S100b

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Since the standard deviation was high, proportional increase cannot be calculated on the basis of mean, therefore median was used to do the calculations. Taking into considerations the median values, there was a 7.33% increase in S100B in intervention group at 24 hr post surgery and 32.35% increase in control group. Likewise, there was a 31.59% decrease of S100B in intervention group at the end of surgery as compared to 27% decrease in the control group. These changes slightly favour the intervention group.

Though we agree with the authors, there is 3.88% decrease in S100B in intervention group at end of surgery vis a vis 7.9% decrease in control group, but the overall trend of S100B was favourable in intervention group [Table 1].
Table 1: Median values of S100B in group C and group D at different time points

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  References Top

1.
Nino C, Mercado JD, Cabrera N, Quintero CI. Neuroprotective role of dexmedetomidine in epilepsy surgery. Neurol India 2019;67:1363.  Back to cited text no. 1
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2.
Bindra A, Kaushal A, Prabhakar H, Chaturvedi A, Chandra SP, Tripathi M,et al. Neuroprotective role of dexmedetomidine in epilepsy surgery: A preliminary study. Neurol India 2019;67:163-8.  Back to cited text no. 2
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