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 ORIGINAL ARTICLE
Year : 2019  |  Volume : 67  |  Issue : 6  |  Page : 1469--1471

Differential DNA Methylation Patterns in Patients with Epilepsy due to Malformations of Cortical Development: A Pilot Study


1 Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC, USA
2 Division of Genetic, Genomic and Metabolic Disorders, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA

Correspondence Address:
Dr. Kuntal Sen
Division of Neurogenetics and Developmental Pediatrics, Children's National Hospital, Washington, DC
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.273638

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Objective: To study the DNA methylation profiles in brain tissue of patients with refractory epilepsy due to malformations of cortical development (MCDs). Materials and Methods: Clinical, neuroimaging, and pathology characteristics were defined for 13 patients who underwent resective surgery for epilepsy. Methylation analysis was performed using Illumina® 450k Methylation Microarray. Data analysis was completed, and pathway identification was done using the R/Bioconductor package. Results: Genes associated with Ephrin–Reelin pathway, potassium channels, and glutathione metabolism were differentially methylated in the MCD group when compared with patients who had no evidence of MCD. Conclusions: Our preliminary data reveal that epigenetic pathways may have a role in the pathobiogenesis of MCDs.






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Online since 20th March '04
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