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 CASE REPORT
Year : 2020  |  Volume : 68  |  Issue : 2  |  Page : 474--477

Optic Neuritis Associated with Anti-NMDA Receptor Antibody in the Remission Phase of Anti-NMDA Receptor Encephalitis


1 Department of Pediatric Neurology, Sichuan Provincial Hospital for Women and Children, Chengdu 610045, People's Republic of China
2 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China
3 Department of Pediatrics, Sichuan Provincial Hospital for Women and Children, Chengdu 610045, People's Republic of China
4 Department of Neurology, Children's Hospital of Chongqing Medical University, Chongqing 400014, People's Republic of China

Correspondence Address:
Tingsong Li
Department of neurology, Children's Hospital of Chongqing Medical University, 136 Zhongshan 2 Road, Chongqing 400014
People's Republic of China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0028-3886.283754

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Optic neuritis is an inflammatory demyelinating disorder of the central nervous system. Anti-NMDA receptor (NMDAR) antibodies encephalitis is also mediated by the inappropriate immunological response. We report a girl who was readmitted because of unilateral eye pain and vision impairment in the remission period of anti-NMDAR encephalitis. Based on the limited available literature on the treatment of optic neuritis associated with anti-NMDA receptor antibody, she was treated with a combination of corticosteroids and intravenous immunoglobulin with clinical improvement. Optic neuritis in the remission phase of anti-N-methyl-D-aspartate receptor encephalitis remains relatively uncommon. It is important to document and follow these patients to understand the pathogenesis of optic neuritis in the setting of anti-NMDAR encephalitis and formulate effective therapeutic strategies.






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