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Year : 2001  |  Volume : 49  |  Issue : 2  |  Page : 144--7

Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.

R Lath, G Chacko, MJ Chandy 
 Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India., India

Correspondence Address:
R Lath
Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.
India

Abstract

Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.



How to cite this article:
Lath R, Chacko G, Chandy M J. Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody. Neurol India 2001;49:144-7


How to cite this URL:
Lath R, Chacko G, Chandy M J. Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody. Neurol India [serial online] 2001 [cited 2020 Aug 11 ];49:144-7
Available from: http://www.neurologyindia.com/text.asp?2001/49/2/144/1277


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