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   2009| May-June  | Volume 57 | Issue 3  
    Online since July 8, 2009

 
 
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INDIAN PERSPECTIVE
Basilar invagination, Chiari malformation, syringomyelia: A review
Atul Goel
May-June 2009, 57(3):235-246
DOI:10.4103/0028-3886.53260  PMID:19587461
Institute and personal experience (over 25 years) of basilar invagination was reviewed. The database of the department included 3300 patients with craniovertebral junction pathology from the year 1951 till date. Patients with basilar invagination were categorized into two groups based on the presence (Group A) or absence (Group B) of clinical and radiological evidence of instability of the craniovertebral junction. Standard radiological parameters described by Chamberlain were used to assess the instability of the craniovertebral junction. The pathogenesis and clinical features in patients with Group A basilar invagination appeared to be related to mechanical instability, whereas it appeared to be secondary to embryonic dysgenesis in patients with Group B basilar invagination. Treatment by facetal distraction and direct lateral mass fixation can result in restoration of craniovertebral and cervical alignment in patients with Group A basilar invagination. Such a treatment can circumvent the need for transoral or posterior fossa decompression surgery. Foramen magnum bone decompression appears to be a rational surgical treatment for patients having Group B basilar invagination. The division of patients with basilar invagination on the basis of presence or absence of instability provides insight into the pathogenesis of the anomaly and a basis for rational surgical treatment.
  20,000 1,543 37
LETTERS TO EDITOR
Azithromycin-induced myasthenic crisis: Reversibility with calcium gluconate
Sunil Pradhan, Vibhor Pardasani, Khimendra Ramteke
May-June 2009, 57(3):352-353
DOI:10.4103/0028-3886.53270  PMID:19587486
  9,808 274 5
ORIGINAL ARTICLES
Once daily baclofen sustained release or gastro-retentive system are acceptable alternatives to thrice daily baclofen immediate release at same daily dosage in patients
Nitin G Sampat, Rahul V Kulkarni, Nathaniel Sase, Nishith H Joshi, Pragnesh B Vora, Amal K Bhattacharya, JD Lakhani, Shravanti S Bhowmik
May-June 2009, 57(3):295-299
DOI:10.4103/0028-3886.53284  PMID:19587470
Background: Baclofen, a GABA-agonist, is currently available as an immediate release (IR) formulation for relieving neurogenic spasticity in a variety of disorders. Baclofen IR requires to be administered three times a day which inadvertently increases the chances of medication noncompliance among patients and is also associated with side effects such as drowsiness and muscle weakness. Aim: To overcome the shortcomings of baclofen IR, two modified formulations, baclofen sustained release (SR) and gastric retentive system (GRS), have been proposed to be equivalent in efficacy to baclofen IR with the administration of a single daily dose. Materials and Methods: Ninety patients with chronic neurogenic muscular spasticity were enrolled requiring 10-20 mg of baclofen IR every eight hours. The patients were randomized to two treatment arms: SR (n = 46) or GRS (n = 44) at the same once-daily dose for four weeks. Efficacy was measured by Ashworth score for muscle tone, spasm score, reflex score, 30-item functional independence score, and patient's diary score for three most affected activities of daily life. Results: The mean Ashworth score changed significantly (P = 0.00) for patients in the SR group from 3.03-2.69 (-0.35) and 3.07-2.70 (-0.37) for patients in the GRS group. There was no significant difference (P = 0.87) between baseline-adjusted Ashworth score reductions on SR (-0.35) and GRS (-0.37). Similar results were obtained for spasm, reflex, and functional independence scores. The mean baseline-adjusted patient-diary scores did not differ significantly between 8 am, 12 pm, 4 pm, and 8 pm (P = 0.96), either on SR (-5.3 to -6.1) or GRS (-7.3 to -8.1), indicating a uniform effect round-the-day on both. Further, sedation scores (mean ± SEM) decreased significantly (P < 0.05) on both SR (10.36 ± 1.37 to 6.18 ± 0.92) and GRS (8.14 ± 1.57 to 5.33 ± 1.11), suggesting better toleration. Conclusion: Once-daily baclofen SR and GRS are efficacious, convenient, and better-tolerated alternatives to baclofen IR in patients with neurogenic spasticity.
  8,579 474 3
The efficacy and safety of gabapentin in carpal tunnel patients: Open label trial
A Kemal Erdemoglu
May-June 2009, 57(3):300-303
DOI:10.4103/0028-3886.53287  PMID:19587471
Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy caused by median nerve compression at the wrist. It results in loss of considerable man days and the effectiveness the various treatment modalities are still debated. Aim: To study the efficacy of gabapentin in patients with CTS. The study aim is to investigate the efficacy of gabapentin in patients with CTS patients who were refractory to the other conservative measures or unwilling for the surgical procedure. Materials and Methods: Forty one patients diagnosed as idiopathic CTS were included in the study. Patients were assessed with symptom severity scale (SSS) and functional status scale (FSS) scores of Boston Carpal Tunnel Questionnaire (BCTQ) before and at 1, 3, and 6 months of the treatment. Response to therapy was determined by using SSS and FSS scores of BCTQ. Results: The median dosage of gabapentin was 1800 mg/daily. Side effects were mild and transient. There was a statistically significant difference in both symptom SSS and FSS scores between before and after treatment in patient groups at the end of six months (P < 0.001). According to grading the changes in subscales of BCTQ, of 41 patients, 34.1 and 29.3 had a ≥ 40% decrease in SSS and FSS, respectively. Conclusion: Gabapentin was found to be partially effective and safe in symptomatic treatment of CTS patients.
  8,593 394 6
"Finger drop sign" in Guillain-Barré syndrome
Arun George, P Abdurehiman, Jose James
May-June 2009, 57(3):282-286
DOI:10.4103/0028-3886.53276  PMID:19587468
Background: Guillain-Barrι syndrome (GBS) is an acute neurological illness affecting the peripheral nervous system causing significant morbidity. The syndrome has been classified electrophysiologically into demyelinating and axonal forms. The clinical features of the axonal variant (acute motor axonal neuropathy-AMAN) are not well characterized, particularly in the Indian context. Objective: To assess the incidence, clinical presentation and disease course of patients with AMAN. Materials and Methods: This is an observational study done at a tertiary referral center in South India. The study period extended from January 2006 to July 2007. All patients with a clinical diagnosis of GBS and satisfying the electrophysiological criteria for AMAN were included. Results: There were 12 cases of AMAN out of a total of 84 cases of GBS. All AMAN patients showed a characteristic pattern of hand weakness predominant weakness of finger extensors with relatively normal power in finger flexors, wrist flexors and extensors. Proximal limb weakness was mild and was present in 85% cases. One patient had cranial nerve palsy and one had hyperreflexia. None of the patients progressed to respiratory failure. Conclusion: AMAN is a distinct subgroup in GBS showing certain distinguishing features, the most notable being predominant weakness of finger extensors.
  7,245 634 4
Experience of microsurgical treatment of brainstem cavernomas: Report of 37 cases
Hao Li, Yan Ju, Bo-wen Cai, Jing Chen, Chao You, Xu-hui Hui
May-June 2009, 57(3):269-273
DOI:10.4103/0028-3886.53269  PMID:19587466
Background: Cavernomas are rare in the brainstem and account for 18-35% of central nervous cavernomas and can cause recurrent hemorrhages, devastating neurological deficits and mortality. Objectives: To summarize the experience of microsurgical treatment of brainstem cavernomas and to investigate curative effect of microsurgical treatment of brainstem cavernomas. Materials and Methods: A retrospective analysis clinical data of 37 patients with brainstem cavernomas seen between 2003 and 2007. The analysis included age distribution, hemorrhage rates, clinical presentation, location of the lesions, and preoperative and postoperative Karnofsky Performance Scale (KPS) scores. The surgical indications, the timing of surgery and the surgical techniques were also assessed. Results: All the 37 patients received microsurgical resections, there was no surgery-related mortality. Histopathological examination confirmed the diagnosis of cavernoma. Postoperatively, 20 patients had functional improvement, 15 patients had no change in the neurological status, and two patients deteriorated. Early surgery was associated with better outcomes. Mean followed up period was 21.5 months (range 6-36 months). During the follow-up 20 patients had resumed activities of daily living (KPS scores of 90-100), 10 patients were able to self-care with some efforts (KPS scores of 70-80), five patients needed considerable assistance (KPS score of 50-60) and two patients suffered hemiparesis (KPS scores of 40). None of the patient had recurrent hemorrhage. Conclusions: Brainstem cavernomas can safely be resected. Successful resection of brainstem cavernomas can be achived by optimal surgical approaches, feasible entry zone and meticulous microsurgical techniques. The goal of surgical intervention should be the total resection of the lesion without any deteriorative in the neurological deficits.
  7,359 323 14
EDITORIALS
Neurosyphilis
Mohan Madhusudhan
May-June 2009, 57(3):233-234
DOI:10.4103/0028-3886.53259  PMID:19587460
  6,206 811 4
ORIGINAL ARTICLES
Current treatment strategy in the management of vestibular schwannoma
Basant K Misra, Harshad R Purandare, Rahul S Ved, Anshul A Bagdia, Pandurang B Mare
May-June 2009, 57(3):257-263
DOI:10.4103/0028-3886.53263  PMID:19587464
Background: The changing trends in the management of vestibular schwannoma (VS) in our practice over the last two decades as well as the current status are presented here. Materials and Methods: The observations are based on the experience of 559 consecutive cases of VS operated by the first author between 1987 and 2008, 438 of which were operated by microsurgery and 139 by gamma knife radiosurgery (GKR) (18 of which were previously operated by the authors). A detailed analysis of microsurgically managed patients in two different periods (100 consecutive patients each before 1993 and 2008) were compared to see the changing trend and document current results. Results and Discussion: In the initial experience (1990s), the emphasis in microsurgery was preserving life, total excision of tumor and preservation of function in that order. In the 21 st century, the emphasis in microsurgery has been all about functional preservation. In 100 consecutive cases of VS (excluding neurofibromatosis-2) that were treated microsurgically between 2005-08, there were four small tumors (<2 cm), 14 medium-sized tumors (2-3 cm) and 82 large tumors (≥3 cm). The total excision rate was 83%. The facial nerve anatomical preservation rate was 96% and function was Grade III House-Brackmann (HB) or better in 87%. Both the total excision rate and facial function of Grade II HB or better were 100% in cases with tumor size less than three cm. Functional hearing preservation was achieved in ten cases. There was no operative mortality. Conclusion: Total excision of VS, though aimed at, is no more pursued at the cost of facial function. Moreover, microsurgery, radiosurgery and observation are all valid options in the management of VS and choosing the correct modality helps in achieving optimal outcome.
  6,017 551 17
REVIEW ARTICLE
Transient ischemic attacks - Definition, risk prediction and urgent management
PN Sylaja, Michael D Hill
May-June 2009, 57(3):252-256
DOI:10.4103/0028-3886.53262  PMID:19587463
Recent evidence suggests that the risk of stroke in first few months after transient ischemic attack is higher than that was previously realized. There are clinical and imaging predictors which help in risk stratifying the patients to identify the high risk group who need immediate hospitalization and urgent evaluation. Recent advances in neuroimaging have revolutionized the evaluation of these patients. Further research is required in the deciding on the optimal treatment of these patients in the acute phase.
  5,340 864 2
ORIGINAL ARTICLES
Differential PARP cleavage: An indication for existence of multiple forms of cell death in human gliomas
Vasantha Kumar Bhaskara, Sundaram Challa, Manas Panigrahi, Phanithi Prakash Babu
May-June 2009, 57(3):264-268
DOI:10.4103/0028-3886.53265  PMID:19587465
Background: Gliomas represent a diverse range of clinical presentation, histological differentiation, and response to therapy. Altered cell proliferation and cell death signals in gliomas are of great interest to elucidate the key molecules involved and to find effective treatment modalities. By considering the role of different proteases in correlation with differential poly (ADP-ribose) polymerase (PARP) fragmentation we have studied the pattern of cell death in human glioma tissues. Materials and Methods: In our study, five different human glioma biopsies were collected and analyzed for the PARP cleavage pattern by using western immunoblotting. Samples were also analyzed for pro-caspase 3, calpain I (µ) and II (m), granzyme-B and apoptosis-inducing factor (AIF). Parallel sections of histologically confirmed astrocytoma and glioblastoma multiforme (GBM) were used for immunohistochemical analysis of cleaved caspase-3, granzyme B, AIF and cyclo-oxygenase -2 (cox-2). Results: We found PARP fragmentation, along with usual ~ 89 kDa and ~ 24 kDa fragments, into other fragments of different molecular weights. Caspase mediated cell death may lead to appearance of larger ~ 89 kDa fragment and smaller ~ 24 kDa fragment indicating existence of apoptosis in the tumors. However, other fragments corresponding to ~ 64 kDa, ~ 54 kDa, and ~ 40 kDa were observed concomitantly in all glial tumor tissues. Conclusions: These results may indicate, not only apoptosis and necrosis, but there occurs the co-existence of intermediate cell death pathways in human glial tumors.
  5,360 426 8
An appraisal of blood-cerebrospinal fluid barrier dysfunction during the course of Guillain Barré syndrome
A Gonzalez-Quevedo, R Fernandez Carriera, Z Lestayo O'Farrill, I Suarez Luis, R Mustelier Becquer, RS Luis Gonzalez
May-June 2009, 57(3):288-294
DOI:10.4103/0028-3886.53282  PMID:19587469
Background: Elevated cerebrospinal fluid (CSF) total protein (TP) concentration (mainly due to a dysfunctional blood-CSF barrier (B-CSFB)) with normal cell count is a hallmark for the diagnosis of Guillain-Barrι syndrome (GBS). Aims: This work presents the evaluation of B-CSFB dysfunction with respect to the course, severity, and clinical features of GBS. Materials and Methods: A sample of CSF was collected on admission from 68 patients of both genders (15 children and 53 adults) diagnosed with GBS. A follow-up CSF sample was obtained approximately 15 days after admission. TP concentration was determined in the CSF and 7.5% polycrylamide gel electrophoresis was employed for serum and CSF protein fractioning. A low percentage of prealbumin fraction was considered a test of impaired B-CSFB. Results: Elevated TP concentration and lower prealbumin were observed in almost 70% of the patients on admission, but this percentage was lower (52.4%) during the first week from onset of symptoms. Both variables were directly associated with the time of evolution of the disease and also with a greater clinical severity. Follow-up CSF studies showed higher CSF TP and lower prealbumin percentages, while deceased patients did not display this response pattern in the follow-up CSF. Conclusions: B-CSFB dysfunction was present in only half of the patients with GBS during the first week from onset and it was directly associated with progression and clinical severity; nevertheless, a low B-CSFB dysfunction response during follow-up was associated with a lethal outcome, suggesting it could also serve a 'protective' effect during regeneration.
  5,295 325 10
Surgical considerations for 'intrinsic' brainstem gliomas: Proposal of a modification in classification
VS Mehta, PS Chandra, Pankaj Kumar Singh, Ajay Garg, GK Rath
May-June 2009, 57(3):274-281
DOI:10.4103/0028-3886.53272  PMID:19587467
Background: Brainstem gliomas are highly heterogeneous tumors both in their clinical manifestation and in their pathology. Despite significant advances in the surgery for brainstem gliomas many aspects of this pathology are still unclear Objective: To evaluate the clinical, radiological and surgical outcome of 40 focal 'intrinsic' brainstem gliomas and propose a surgical strategy-oriented classification. Materials and Methods: A total of 40 focal 'intrinsic' ("expanding variety") tumors have been operated over a period of 8.5-years (January 1998-June 2007). Our criteria included patients with (1) well-defined gadolinium enhancing tumor; (2) relatively long duration of symptoms (> six months) and (3) good neurological functional status and independent for all activities of daily living. The cutoff size of 2 cm was not rigidly adhered to. Results: The 'intrinsic' brainstem tumors were classified into three types: Expanding, diffuse infiltrative and pure ventral varieties. Only patients with expanding variety of brainstem gliomas were subjected to surgery, mean age 19.2 years (range 4-55 years) and male to female ration mean: 3:2). The tumor location included pons (n=19), midbrain (n=13) and medulla (n=8). Surgical approaches included midline suboccipital (n=28), retromastoid (n=7), subtemporal (n=3) and supracerebellar-infratentorial (n=2). Thirty-two cases with 'diffuse infiltrative' and 'pure ventral' variety were given radiotherapy only. Histology pathology revealed pilocytic variety (n=10), Grade II (n=17) and Grade III (n=13). There was one death in the surgical series (due to aspiration). Complications included meningitis (n=2), wound infection (n=1), chest infection (n=5) and transient mutism (n=1). Follow-up ranged from 3-68 months. Overall, 36 improved /remained same and three worsened in their clinical status at the time of discharge. Conclusion: The surgical management of intrinsic brainstem tumors presents a surgical challenge; radical excision yielded a good outcome in the majority of cases. The authors propose a classification system for 'intrinsic' brainstem tumors for defining surgical strategy.
  5,080 409 16
LETTERS TO EDITOR
'Garland sign' in amyotrophic lateral sclerosis
Atma Ram Bansal, Gopal Krishna Dash, Ashalatha Radhakrishnan, Chandrasekharan Kesavadas, Muraleedharan Nair
May-June 2009, 57(3):354-355
DOI:10.4103/0028-3886.53273  PMID:19587488
  4,960 376 -
ORIGINAL ARTICLE
Comparison of the analgesic effect of ibuprofen with mesalamine after discectomy surgery in patients with lumbar disc herniation: A double-blind randomized controlled trial
Hamidreza Pazooki Toroudi, Mohammad Borghei Razavi, Hamid Borghei Razavi, Reza Mostafavi Tabatabayi, Yaser Tolouei Tabar, Seyyed Taha Yahyavi, Mehdi Montazer
May-June 2009, 57(3):305-309
DOI:10.4103/0028-3886.53292  PMID:19587472
Background: Pain management is an important component in the postoperative period following discectomy. Aims: We hypothesized that mesalamine considering its better safety profile, is likely to be a better choice, if it would be as effective as ibuprofen in controlling post-discectomy pain. Settings and Design: A double-blind randomized controlled trial was performed on patients who underwent lumbar discectomy surgery. Materials and Methods: Of the 58 patients who had lumbar discectomy, 27 patients were randomized to oral ibuprofen 500 mg and 31 patients to mesalamine 400 mg, three times a day for nine days following surgery. There was no placebo group. Severity of pain was assessed by using 10- cm visual analogue scale (VAS), once before operation and for nine days after. Statistical Analysis: Mean ± SD pain scores were compared between groups and the statistical difference was estimated by Student's test using SPSS (Version 13). We also calculated the power of each t-test. Repeated measure ANOVA was performed for measuring the effect of time. Results: The age range of the patients was 35 to 60 years (mean: 42.2 years). Mean ± SD preoperative pain scores for ibuprofen or mesalamine-treated groups were 7.852 ± 2.441 and 7.806 ± 2.892, respectively. At the end of day 9, mean ± SD of pain score was 2.704 ± 2.284 and 2.717 ± 2.273 for ibuprofen and mesalamine-treated groups respectively. Both drugs significantly reduced postoperative pain and there was no statistically significant difference between the two groups.Conclusions: Since both drugs showed almost equal analgesic effect, considering its safety profile mesalamine, seems to be the preferred choice to alleviate post-discectomy surgery pain.
  4,700 271 6
CASE REPORTS
Spontaneous intracranial extradural hematoma: Case report and literature review
Fan Xue Zheng, You Chao
May-June 2009, 57(3):324-326
DOI:10.4103/0028-3886.53288  PMID:19587476
Spontaneous extradural hematoma (EDH) is an uncommon form of intracranial hematoma and is caused by the adjacent sinus and otic infections, dural vascular malformations and disorders of blood coagulation. We report spontaneous EDH in a 54-year old women with chronic kidney disease (CKD) on intermittent hemodialysis. She was successfully managed by conservative treatment. The EDH in her was probably related to the coagulation abnormalities associated with CKD, hemodialysis or heparin use during the dialysis.
  4,297 336 13
BRIEF REPORTS
Retained surgical sponge in differential diagnosis of paraspinal soft-tissue mass after posterior spinal surgery: Report of eight cases
Cem Atabey, Mehmet Turgut, Ahmet Turan Ilica
May-June 2009, 57(3):320-323
DOI:10.4103/0028-3886.53289  PMID:19587475
Background: In the postoperative period of posterior spinal surgery, surgeons usually encounter a wide spectrum of complications, including retained surgical sponge, gossypiboma. Materials and Methods: Retrospective review of case records of eight patients diagnosed with gossypiboma with emphasis on computed tomography (CT) and magnetic resonance imaging (MRI) findings. Results: All the eight patients presented with low back pain and/or symptoms of infection, such as draining from the incision site, fever, and tenderness. The diagnosis was confirmed by the imaging findings on MRI with gadolinium enhancement. Conclusion: Retained paravertebral surgical sponges are seldom reported due to medicolegal implications. Awareness of this complication among neurosurgeons and radiologists is essential to avoid unnecessary morbidity.
  4,387 231 11
Mechanical device the Penumbra system in the management of acute stroke: Report of five cases
Vikram Huded, Rashmi Saraf, Uday Limaye
May-June 2009, 57(3):310-312
DOI:10.4103/0028-3886.53293  PMID:19587473
Use of mechanical devices in acute ischemic stroke has shown promise not only in recanalization rates but also with better clinical outcome and also extension of the window period to 8 hours. This is the first reported series of use of mechanical devices in India. We report five patients with acute stroke in whom mechanical devices (Penumbra System, Alameda, California) were used for thrombolysis. All the treated vessels (100%) were successfully re-canalized, Trials In Myocardial Infarction (TIMI) score of 3. At 90-day follow-up, of the 5 patients treated, 2 had modified Rankin score (mRS) of < 2. This small series shows the safety and efficacy of the Penumbra System in the thrombolysis of large vessel occlusive disease.
  4,113 417 9
CASE REPORTS
An anatomical variation of the third common digital nerve and recurrent motor branch of the median nerve
Emre Demircay, Serdar Kabatas, Tufan Cansever, Cem Yilmaz
May-June 2009, 57(3):337-339
DOI:10.4103/0028-3886.53281  PMID:19587480
Carpal tunnel syndrome (CTS) is an entrapment neuropathy where the median nerve is compressed in the carpal canal. There are many variations of the distal branches of the median nerve at the wrist. Anatomical variations of this nerve have fundamental clinical importance to prevent injuries, especially during limited open or endoscopic surgical procedures. A case is presented of an anomalous course of the recurrent motor branch of the median nerve and high division of the third common digital nerve seen in a limited open carpal tunnel release.
  4,233 232 5
Chorea as the presentating feature of neurosyphilis
Serkan Ozben, Canan Erol, Feriha Ozer, Raziye Tiras
May-June 2009, 57(3):347-349
DOI:10.4103/0028-3886.53277  PMID:19587483
Syphilis is still a significant public health problem in developing countries. Although chorea is a very rare manifestation of neurosyphilis, it might be on occasions the initial symptom. This report presents a patients with neurosyphilis who had chorea as the initial presenting symptom.
  3,794 263 10
Transorbital penetrating cerebral injury with a ceramic stone: Report of an interesting case
GD Satyarthee, Sachin A Borkar, Anuj Kumar Tripathi, BS Sharma
May-June 2009, 57(3):331-333
DOI:10.4103/0028-3886.53285  PMID:19587478
Penetrating cranial injury is a potentially life-threatening condition. The majority of war injuries are high-velocity penetrating cranial injuries; but in civilian cases, most penetrating cranial wounds are low-velocity type. We report an interesting case of transorbital penetrating cranial injury with a knife-sharpening stone made up of ceramic in a 28-year-old male. The pertinent literature is reviewed and management of such cases is discussed.
  3,612 212 24
BRIEF REPORTS
Intra-arterial thrombolysis in basilar artery occlusions combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitors in basilar artery thrombosis
SB Gaikwad, MV Padma, EJ Moses, Kanika Sethi, M Tripathi, R Bhatia, K Prasad, NK Mishra
May-June 2009, 57(3):313-319
DOI:10.4103/0028-3886.53291  PMID:19587474
Basilar artery thrombosis has high morbidity and mortality. Though intra-arterial thrombolytics have proven efficacy in the treatment of acute basilar artery occlusion, the elevation of procoagulant factors in the blood after intra-arterial thrombolysis could result in subsequent thrombus formation and clinical deterioration. Glycoprotein IIb/IIIa inhibitors have been shown to reduce this elevation in procoagulants. We present a pilot study of three cases of acute basilar artery occlusion treated with a combination of intra-arterial thrombolytics and Gp IIb/IIIa inhibitor with remarkable clinical recovery seen in all the patients.
  3,513 252 1
CASE REPORTS
Intrathyroidal parathyroid adenoma presenting with neuromuscular manifestation
Xiaodong Zhu, Hui Zhai, Shao Fang Tang, Yan Cheng
May-June 2009, 57(3):340-343
DOI:10.4103/0028-3886.53280  PMID:19587481
Primary hyperparathyroidism (PHPT) is not an uncommon endocrine disorder. We describe a patient with PHPT who presented with progressive proximal limbs weakness and dystrophic changes of leg muscles. Serum calcium, alkaline phosphatase, and parathyroid hormone were elevated and serum phosphorus was low. Neck computerized tomography scan showed a parenchymatous tumor in the right lobe of the thyroid. The tumor presented as a 'cold nodule' in the dual-phase single-agent Tc-99m MIBI scan. The right lobectomy examination confirmed the diagnosis of an intrathyroidal parathyroid adenoma of the right gland.
  3,539 201 -
Peroral extrusion of ventriculoperitoneal shunt: Case report and review of literature
K Sridhar, Vikram Karmarkar
May-June 2009, 57(3):334-336
DOI:10.4103/0028-3886.53283  PMID:19587479
A rare complication of ventriculoperitoneal shunting (VPS) is bowel perforation by the peritoneal catheter of the shunt tube. Rarer still is the peroral extrusion of such a perforated shunt. A two-month-old infant with history of neonatal meningitis, presented with a large head, bulging fontanelle, and hydrocephalus. A VPS was inserted. The child was doing well till the age of eight months, when following vomiting, the peritoneal end of the shunt came out through the mouth. The shunt was removed and antibiotics started. At follow up after 12 months, the child was doing well. Peroral extrusion of the shunt tube needs prompt treatment, including removal of the extruded shunt tube, and attention to bowel perforation and possible cerebrospinal fluid infection. The reported patient is younger than the five cases reported earlier. Strategies in the management of this complication are reviewed. An individualized approach is essential for the successful treatment of this rare complication.
  3,433 267 11
NEUROIMAGE
Intracranial epidermoid cyst: Magnetic resonance imaging features
Rima Kumari, Bhuvnesh Guglani, Nitij Gupta, Sujata Chaturvedi
May-June 2009, 57(3):359-360
DOI:10.4103/0028-3886.53266  PMID:19587491
  3,364 321 6
EDITORIALS
Role of surgery in brainstem gliomas
Aaron Mohanty
May-June 2009, 57(3):231-232
DOI:10.4103/0028-3886.53258  PMID:19587459
  2,908 512 2
COMMITTEE REPORT
A pragmatic clinicopathobiological grouping/staging system for gliomas: Proposal of the Indian TNM subcommittee on brain tumors
Tejpal Gupta, Rajiv Sarin, Rakesh Jalali, Suash Sharma, Purna Kurkure, Atul Goel
May-June 2009, 57(3):247-251
DOI:10.4103/0028-3886.53261  PMID:19587462
Background: There is no universally accepted staging system for primary brain tumors wherein prognostication is mainly based on complex composite indices . Aim: To develop a simple, pragmatic, and widely applicable grouping/staging system for gliomas, the most common primary brain tumor. Materials and Methods: An expert neurooncology panel with representation from radiation oncology, neurosurgery, pathology, radiology, and medical oncology had several rounds of discussion on issues pertinent to brain tumor staging. The trade off was between the accuracy of prognostic categorization and a pragmatic, widely applicable approach. Results and Recommendations: The Tumor-Node-Metastasis staging was considered irrelevant for gliomas that seldom metastasize to lymphatics or outside the neuraxis. Instead, a 4-point staging/grouping system is proposed, using histological grade as the main prognostic variable and at least one stage migration based on other unfavorable features such as tumor location (brainstem); age (<5 years for all grades, >50 years for high-grade, and >40 years for low-grade gliomas); poor neurological performance status (NPS 2-4); multicentricity and/or gliomatosis; and adverse biological parameters (proliferative index, angiogenesis markers, apoptotic index, cytogenetic abnormalities, and molecular markers). Conclusion: In absence of a grouping/staging system for primary brain tumors, prognostification is mostly based on complex composite indices. The proposed clinicopathobiological grouping/staging system for gliomas is a simple, pragmatic, and user-friendly tool with a potential to fulfill the objectives of staging classification.
  3,094 316 -
CASE REPORTS
Left subclavian artery aneurysm secondary to syphilitic arteritis presenting with a right ischemic cerebellar infarction
Chih Ming Lin
May-June 2009, 57(3):344-346
DOI:10.4103/0028-3886.53279  PMID:19587482
We report a 28-year-old male who presented with severe vertigo, vomiting, diplopia, clumsiness of right extremities. Physical examination revealed low reading of blood pressure in the left upper limb and evidence of mild left upper limb ischemia. On neurological examination he had right cerebellar ataxia. Computed tomography and magnetic resonance imaging, revealed an acute right cerebellar infarction in the anterior inferior cerebellar artery territory. Doppler ultrasono­graphy revealed an aneurysm of the left subclavian artery. The patient was tested positive for serology of syphilis,
  3,107 207 5
Surgical extraction of migrated coils via proximal segment of the anterior cerebral artery: An emergency alternative
Zhi Chen, Weihua Tang, Hua Feng, Gang Zhu
May-June 2009, 57(3):327-330
DOI:10.4103/0028-3886.53286  PMID:19587477
Coil migration is a severe complication in endovascular treatment. We report our experience of prompt surgical extraction of migrated coils via excised proximal A1 following endovascular embolization of intracranial aneurysms in two patients. Both patients had to undergo coiling or stent-assisted coiling for cerebral aneurysms, and while operating the coils protruded and migrated to the bifurcation of internal carotid artery and middle cerebral artery. Immediate craniotomy was performed after unsuccessful or unfeasible endovascular retrieval. The migrated coils were removed via excised proximal A1, and the patients recovered well without any neurological deficits. We suggest that this surgical procedure might be an alternative route in selected patients with good cross circulation in emergency. In addition, a rare occasion of coil migration after stent-assisted coiling is also described in one patient, which might have resulted from unsatisfactory wall apposition of the stent due to a curved vessel.
  2,904 192 4
NEUROIMAGE
Fibrolipomatous hamartoma of the median nerve presenting with carpal tunnel syndrome
Radha Sarawagi, GA Anderson, Rekha S Cherian
May-June 2009, 57(3):361-362
DOI:10.4103/0028-3886.53264  PMID:19587492
  2,740 204 4
LETTERS TO EDITOR
Multiple giant cavernous angiomas of the brain
LN Tripathy, SN Singh
May-June 2009, 57(3):350-351
DOI:10.4103/0028-3886.53267  PMID:19587484
  2,596 211 1
Post-traumatic isolated superior rectus hematoma
Prasad Krishnan, K Sridhar, Mukul Mondal
May-June 2009, 57(3):351-352
DOI:10.4103/0028-3886.53268  PMID:19587485
  2,554 179 -
Conus ependymoma with holocord syringomyelia
Sachin A Borkar, GD Satyarthee, BS Sharma
May-June 2009, 57(3):353-354
DOI:10.4103/0028-3886.53271  PMID:19587487
  2,535 196 7
Comprehensive rural epilepsy surveillance programme in Uttarakhand state of India
Deepak Goel, Alka Agarwal, JS Dhanai, VD Semval, V Mehrotra, V Saxena, B Maithili
May-June 2009, 57(3):355-356
DOI:10.4103/0028-3886.53274  PMID:19587489
  2,493 201 6
Rapid resolution of hydrocephalus due to simultaneous movements of hematoma in the trigono-occipital horn and the aqueduct
Naoshi Hagihara, Toshi Abe, Kohei Inoue, Mitsuo Watanabe, Kazuo Tabuchi
May-June 2009, 57(3):357-358
DOI:10.4103/0028-3886.53275  PMID:19587490
  1,982 167 3
INVITED COMMENTARY
Invited Commentary
Sunil Pradhan
May-June 2009, 57(3):286-287
  1,455 171 -
Invited Commentary
D Taverner
May-June 2009, 57(3):303-304
  1,320 121 -
Online since 20th March '04
Published by Wolters Kluwer - Medknow