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Figure 2: Case 2. Magnetic resonance imaging (MRI) T2-weighted FLAIR coronal section showing hyperintensity in the pineal region suggestive of a mass lesion with surrounding edema and moderate obstructive hydrocephalus (a; MRI). Histophotomicrographs show a tumor composed of polygonal cells (epithelioid morphology) arranged in solid sheets interspersed with tubular and single to multilayered papillary architecture (b and c: H and E, × 100; d and e: H and E, × 400). The tumor was immunoreactive for vimentin (f), p53 (i; IHC, moderate intensity), Bcl-2 (j; IHC), S-100 protein (k; IHC, cytoplasmic) and focally for CK (g; IHC), while it was negative for EMA (n; IHC), NSE (h; IHC), synaptophysin (m; IHC), GFAP (l; IHC). MIB-1 LI (o; IHC) was 1-2%

Figure 2: Case 2. Magnetic resonance imaging (MRI) T2-weighted FLAIR coronal section showing hyperintensity in the pineal region suggestive of a mass lesion with surrounding edema and moderate obstructive hydrocephalus (a; MRI). Histophotomicrographs show a tumor composed of polygonal cells (epithelioid morphology) arranged in solid sheets interspersed with tubular and single to multilayered papillary architecture (b and c: H and E, × 100; d and e: H and E, × 400). The tumor was immunoreactive for vimentin (f), p53 (i; IHC, moderate intensity), Bcl-2 (j; IHC), S-100 protein (k; IHC, cytoplasmic) and focally for CK (g; IHC), while it was negative for EMA (n; IHC), NSE (h; IHC), synaptophysin (m; IHC), GFAP (l; IHC). MIB-1 LI (o; IHC) was 1-2%