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Figure 2: (a-c) Case 1: Transverse section of a nerve fascicle shows reduction in myelinated fiber density (a) with consequent fibrosis of endoneurium (b); myelin stains highlight significant myelinated fiber loss with minimal regeneration (c). (d-f) Case 2: Nerve biopsy shows endoneurial edema with axonal degeneration and myelin ovoids (d, arrow); inset shows macrophages scavenging degrading myelin (arrow). A large epineurial vessel (e) shows periadventitial infiltration by lymphomononuclear cells (arrow). Sectoral loss of myelinated fibers is evident in the upper quadrant of fascicle on myelin stains (f) (a: H and E ×80; b: Masson Trichrome stain ×80; c: Kulchitsky Pal ×160; d: H and E ×240; d, inset: CD68 immunostain ×240; e: H and E ×240; f: Kulchitsky Pal ×160)

Figure 2: (a-c) Case 1: Transverse section of a nerve fascicle shows reduction in myelinated fiber density (a) with consequent fibrosis of endoneurium (b); myelin stains highlight significant myelinated fiber loss with minimal regeneration (c). (d-f) Case 2: Nerve biopsy shows endoneurial edema with axonal degeneration and myelin ovoids (d, arrow); inset shows macrophages scavenging degrading myelin (arrow). A large epineurial vessel (e) shows periadventitial infiltration by lymphomononuclear cells (arrow). Sectoral loss of myelinated fibers is evident in the upper quadrant of fascicle on myelin stains (f) (a: H and E ×80; b: Masson Trichrome stain ×80; c: Kulchitsky Pal ×160; d: H and E ×240; d, inset: CD68 immunostain ×240; e: H and E ×240; f: Kulchitsky Pal ×160)