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Figure 1: Simplified model of the costameres. The costameres are transverse structures organized in a rib-like pattern, which lie at the sarcolemma over the Z and M lines of nearby myofibrils. This model depicts the relationship of costameres with basal lamina, plasma membrane and cytoskeleton proteins. Two sets of plasma membrane proteins connect the contractile apparatus to the costameres at the sarcolemma: One set via the dystroglycan complex (á-DG andβ-DG) and the other via the integrins (á7β1)

Figure 1: Simplified model of the costameres. The costameres are transverse structures organized in a rib-like pattern, which lie at the sarcolemma over the Z and M lines of nearby myofibrils. This model depicts the relationship of costameres with basal lamina, plasma membrane and cytoskeleton proteins. Two sets of plasma membrane proteins connect the contractile apparatus to the costameres at the sarcolemma: One set via the dystroglycan complex (<i>á</i>-DG andβ-DG) and the other via the integrins (<i>á</i>7β1)