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Figure 2: Immunohistochemistry showing loss of hamartin (a; ×400) and tuberin (b; ×400) in tumor cells. Robust expression of phospho-p70S6 kinase (c; ×400) and S6 ribosomal protein (d; ×400), and overexpression of phospho-S6 ribosomal protein (e; ×400) and phospho-4E-BP1 (f; ×400), are seen in tumor cells. Stat3 cytoplasmic positivity (g; ×400), focal nuclear positivity for phospho-Stat3 (h; ×400), and tumor cells immunonegative for phospho-Stat3 (I; ×400) are shown

Figure 2: Immunohistochemistry showing loss of hamartin (a; ×400) and tuberin (b; ×400) in tumor cells. Robust expression of phospho-p70S6 kinase (c; ×400) and S6 ribosomal protein (d; ×400), and overexpression of phospho-S6 ribosomal protein (e; ×400) and phospho-4E-BP1 (f; ×400), are seen in tumor cells. Stat3 cytoplasmic positivity (g; ×400), focal nuclear positivity for phospho-Stat3 (h; ×400), and tumor cells immunonegative for phospho-Stat3 (I; ×400) are shown